The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Neuropsychological performance in medicated vs. unmedicated patients with obsessive–compulsive disorder
Abstract
To date, there have been no formal investigations of neuropsychological performance in patients with obsessive-compulsive disorder (OCD) taking psychotropic medications. The purpose of this study was to determine whether medicated and unmedicated patients with OCD demonstrate differences in neuropsychological functioning. Fifty-two patients with a primary DSM-IV diagnosis of OCD participated in the study; 28 were taking serotonin reuptake inhibitors (SRIs), and 24 were treatment-naïve (n=8) or had finished a washout period prior to their inclusion in other studies (n=16). The groups were well matched with regard to demographic and clinical variables, including symptom severity. Each group was administered a comprehensive neuropsychological battery to assess general intelligence, attention, verbal and non-verbal working memory, declarative and procedural learning, visuo-constructive skills, and executive functions. SRI-medicated did not differ from SRI-free patients on any neuropsychological measure. Benzodiazepines seemed to improve the patients' functioning on a semantic verbal fluency test. In addition, there were significant interactions between SRIs and benzodiazepines on the perseverative errors of the Wisconsin Card Sorting Test and on reaction times. SRI-medicated patients with OCD are able to perform on cognitive functioning tests at a comparable level with that of SRI-free patients, and these results have positive implications for OCD patients who respond to SRIs. The interactions between SRIs and benzodiazepines and their effect on cognition in OCD are likely to be complex and deserve further study.
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“Some studies have suggested that medication may not influence cognitive function or group differences in activation.6,50”
From Cognitive inflexibility and frontal–cortical activation in pediatric obsessive–compulsive disorder (2010) · cites this paper as [50]
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Cites
An inventory for measuring depression
BECK, A. T. (1961) · Archives of General Psychiatry · doi:10.1001/archpsyc.1961.01710120031004 · Cited by 38,032
The Yale-Brown Obsessive Compulsive Scale: I. Development, Use, and Reliability
Goodman, W. K. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810110048007 · Cited by 7,712
(1995) · Cited by 2,809
Deficits on subject-ordered tasks after frontal- and temporal-lobe lesions in man
Petrides, M., & Milner, B. A. (1982) · Neuropsychologia · doi:10.1016/0028-3932(82)90100-2 · Cited by 1,317
The functional equivalence of problem solving skills
Simon, H. A. (1975) · Cognitive Psychology · doi:10.1016/0010-0285(75)90012-2 · Cited by 775
Cornblatt, B. A., Risch, N. J., Faris, G., Friedman, D., & Erlenmeyer-Kimling, L. (1988) · Psychiatry Research · doi:10.1016/0165-1781(88)90076-5 · Cited by 682
A 40-Year Follow-up of Patients With Obsessive-compulsive Disorder
Skoog, G., & Skoog, I. G. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.2.121 · Cited by 634
Modell, J. G., Mountz, J. M., Curtis, G. C., & Greden, J. F. (1989) · Journal of Neuropsychiatry · doi:10.1176/jnp.1.1.27 · Cited by 425
Organizational strategies mediate nonverbal memory impairment in obsessive–compulsive disorder
Savage, C. R., Baer, L., Keuthen, N. J., Brown, H. D., Rauch, S. L., & Jenike, M. A. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00278-9 · Cited by 423
Cognitive Deficits in Obsessive–Compulsive Disorder on Tests of Frontal–Striatal Function
Purcell, R., Maruff, P., Kyrios, M., & Pantelis, C. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00201-1 · Cited by 313
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Anxiety and working memory capacity: A meta-analysis and narrative review.
Moran, T. P. (2016) · Psychological Bulletin · doi:10.1037/bul0000051 · Cited by 776
A review on cognitive impairments in depressive and anxiety disorders with a focus on young adults
Castaneda, A. E., Tuulio‐Henriksson, A., MARTTUNEN, M. J., Suvisaari, J., & Lönnqvist, J. K. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.06.006 · Cited by 755
The neuropsychology of adult obsessive–compulsive disorder: A meta-analysis
Abramovitch, A., Abramowitz, J. S., & Mittelman, A. (2013) · Clinical Psychology Review · doi:10.1016/j.cpr.2013.09.004 · Cited by 444
Neuropsychological performance in obsessive-compulsive disorder: a critical review
Kuelz, A. K., Hohagen, F., & Voderholzer, U. (2004) · Biological Psychology · doi:10.1016/j.biopsycho.2003.07.007 · Cited by 436
Metadata
- Authors
- Mataix-Cols, D., Alonso, P., Pifarré, J., Menchón, J. M., & Vallejo, J.
- Affiliations
- Bellvitge University Hospital (ES)
- Hospital Universitari de Santa Maria (ES)
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2002-04
- Volume
- 109
- Issue
- 3
- Pages
- 255-264
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W1979451759
- Cited by
- 116
- References
- 37
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 5 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 6 · 2014: 10 · 2013: 11 · 2012: 4
- FWCI
- 6.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Psychological Association
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- obsessive-compulsive disorder, neuropsychological performance, serotonin reuptake inhibitors, benzodiazepines, working memory, executive function, verbal fluency, Wisconsin Card Sorting Test, reaction time, treatment-naive patients
- MeSH terms
- Adult, Benzodiazepines, Drug Therapy, Combination, Female, Humans, Male, Neuropsychological Tests, Obsessive-Compulsive Disorder, Antipsychotic Agents, Anti-Anxiety Agents, Selective Serotonin Reuptake Inhibitors
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