Adhesion molecule expression and regulation on cells of the central nervous system

Lee, Sung Joong; Benveniste, Etty N

doi:10.1016/s0165-5728(99)00084-3

Cited by 296Cell Adhesion Molecules ResearchMultiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Adhesion molecule expression and regulation on cells of the central nervous system

Lee, Sung Joong, Benveniste, Etty N·1999·Journal of Neuroimmunology

DOI 10.1016/s0165-5728(99)00084-3

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Abstract

Cellular adhesion molecules were initially defined as cell surface structures mediating cell-cell and cell-extracellular matrix (ECM) interactions. Adhesion molecules involved in immune responses have been classified into three families according to their structure: selectins, immunoglobulin (Ig) superfamily, and integrins. It has been well documented that adhesion molecules of these family members (E-selectin, ICAM-1, and VCAM-1) are expressed on brain microvessel endothelial cells in active lesions of multiple sclerosis (MS) brain. In addition, accumulating data show that glial cells can express some of these adhesion molecules upon activation: astrocytes can express ICAM-1, VCAM-1, and E-selectin, and microglia express ICAM-1 and VCAM-1. In vitro studies show that these adhesion molecules are actively regulated by several cytokines which have relevance to MS or experimental autoimmune encephalomyelitis (EAE). In addition, soluble forms of adhesion molecules have been found in the serum and cerebrospinal fluid (CSF) of MS patients, and may be useful diagnostically. Experimental therapy of EAE using antibodies against several adhesion molecules clearly shows that adhesion molecules are critical for the pathogenesis of EAE. Thus far, the function of adhesion molecule expression on brain endothelial and glial cells has not been clearly elucidated. Studies on the possible role of adhesion molecules on brain endothelial and glial cells will be helpful in understanding their involvement in immune responses in the central nervous system (CNS).

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ICAM-1 and VCAM-1 are adhesion molecules that are upregulated in endothelial cells under inflammatory conditions.
“ICAM-1 and VCAM-1 are adhesion molecules that are upregulated in endothelial cells under inflammatory conditions.27”
From CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease (2018) · cites this paper as [27]

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Authors: Lee, S. J., & Benveniste, E. N.
Affiliations: University of Alabama at Birmingham (US)
ORCID: Lee, Sung Joong
Benveniste, Etty N
Venue: Journal of Neuroimmunology
Publisher: Elsevier BV
Published: 1999-08
Volume: 98
Issue: 2
Pages: 77-88
ISSN: 0165-5728 (ISSN-L)
DOI: 10.1016/s0165-5728(99)00084-3
OpenAlex: W2064017800
Cited by: 296
References: 116
Citations by year: 2026: 4 · 2025: 2 · 2024: 8 · 2023: 7 · 2022: 6 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 6 · 2016: 6 · 2015: 8 · 2014: 10 · 2013: 14 · 2012: 12
FWCI: 1.06
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Neuroimmunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01mh055795-05, 5p01ns029719-10, 5p01ns034856-05)
National Institute of Mental Health (MH-55795)
National Institute of Neurological Disorders and Stroke (NS29719, NS 34856)
Topics: Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: adhesion molecules, multiple sclerosis, experimental autoimmune encephalitis, brain microvascular endothelial cells, glial cells, astrocytes, microglia, ICAM-1, VCAM-1, E-selectin, selectins, integrins, immunoglobulin superfamily, cytokine regulation, soluble adhesion molecules, cerebrospinal fluid biomarkers, CNS immune response
MeSH terms: Animals, Central Nervous System, Humans, Neuroglia, Neurons, Cell Adhesion Molecules

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Adhesion molecule expression and regulation on cells of the central nervous system

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