α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1
Abstract
The mucosal vascular addressin, MAdCAM-1, is an immunoglobulin superfamily adhesion molecule for lymphocytes that is expressed by mucosal venules and helps direct lymphocyte traffic into Peyer's patches (PP) and the intestinal lamina propria. We demonstrate that the lymphocyte integrin alpha 4 beta 7, also implicated in homing to PP, is a receptor for MAdCAM-1. Certain antibodies to alpha 4 and beta 7 integrin chains but not to the beta 2 integrin LFA-1 inhibit lymphocyte binding to purified MAdCAM-1 and to MAdCAM-1 transfectants. Lymph node lymphocytes, alpha 4 beta 7+ TK1 lymphoma cells, and a beta 7-transfected variant of an alpha 4+ B cell line, 38C13, bind constitutively to MAdCAM-1. Binding is enhanced by Mn(++)-induced integrin activation. The related integrin alpha 4 beta 1 supports efficient binding to VCAM-1 but not to MAdCAM-1, even after integrin activation, indicating that MAdCAM-1 is a preferential ligand for alpha 4 beta 7. Alpha 4 beta 7 can also bind VCAM-1, but this requires greater integrin activation than binding to MAdCAM-1. The findings imply a selective role for the interaction of alpha 4 beta 7 and MAdCAM-1 lymphocyte in homing to mucosal sites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Organ-specific non-peripheral cells with tissue-homing markers can transiently appear in blood cell preparations.
“In these blood cell preparations, organ-specific non-peripheral cells with tissue-homing markers can also transiently appear. 16-20”
From Revealing viral and cellular dynamics of HIV-1 at the single-cell level during early treatment periods (2023) · cites this paper as [17]
Cited by
Sorted by citations
Targeting integrin pathways: mechanisms and advances in therapy
Pang, X., He, X., Qiu, Z., Zhang, H., Xie, R., Liu, Z., Gu, Y., Zhao, N., Xiang, Q., & Cui, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01259-6 · Cited by 1,275 · see citing works
Mechanisms That Regulate the Function of the Selectins and Their Ligands
VESTWEBER, D., & BLANKS, J. E. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.181 · Cited by 932 · see citing works
Benson, M. J., Pino-Lagos, K., Rosemblatt, M., & Noelle, R. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070719 · Cited by 847 · see citing works
Dutton, R. W., Bradley, L. M., & Swain, S. L. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.201 · Cited by 832 · see citing works
Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation
Kleinschek, M. A., Boniface, K., Sadekova, S., Grein, J., Murphy, E. E., Turner, S. P., Raskin, L., Desai, B., Faubion, W. A., de Waal Malefyt, R., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20081712 · Cited by 460 · see citing works
Lages, C. S., Suffia, I., Velilla, P. A., Huang, B., Warshaw, G., Hildeman, D. A., Belkaid, Y., & Chougnet, C. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.3.1835 · Cited by 399 · see citing works
Chemokines in the systemic organization of immunity
Campbell, D. J., Kim, C. H., & Butcher, E. C. (2003) · Immunological Reviews · doi:10.1034/j.1600-065x.2003.00067.x · Cited by 330 · see citing works
Self-citationAdhesion molecule expression and regulation on cells of the central nervous system
Lee, S. J., & Benveniste, E. N. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00084-3 · Cited by 296 · see citing works
Role of β7 Integrins in Intestinal Lymphocyte Homing and Retention
Gorfu, G., Rivera-Nieves, J., & Ley, K. (2009) · Current Molecular Medicine · doi:10.2174/156652409789105525 · Cited by 292 · see citing works
Current aspects of mucosal immunology and its influence by nutrition.
Kudsk, K. A. (2002) · The American Journal of Surgery · doi:10.1016/s0002-9610(02)00821-8 · Cited by 267 · see citing works
Vedolizumab treatment for immune checkpoint inhibitor-induced enterocolitis
Bergqvist, V., Hertervig, E., Gedeon, P., Kopljar, M., Griph, H., Kinhult, S., Carneiro, A., & Marsal, J. (2017) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-017-1962-6 · Cited by 234 · see citing works
Cell Adhesion Molecules—Update
Elangbam, C. S., Qualls, C. W., & Dahlgren, R. R. (1997) · Veterinary Pathology · doi:10.1177/030098589703400113 · Cited by 215 · see citing works
To respond or not to respond — a personal perspective of intestinal tolerance
Mowat, A. M. (2018) · Nature Reviews Immunology · doi:10.1038/s41577-018-0002-x · Cited by 206 · see citing works
Abu-Sbeih, H., Ali, F. S., Alsaadi, D., Jennings, J., Luo, W., Gong, Z., Richards, D. M., Charabaty, A., & Wang, Y. (2018) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-018-0461-4 · Cited by 215 · see citing works
Fukuyama, S., Hiroi, T., Yokota, Y., Rennert, P. D., Yanagita, M., Kinoshita, N., Terawaki, S., Shikina, T., Yamamoto, M., Kurono, Y., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00339-4 · Cited by 207 · see citing works
Öhman, L., Isaksson, S., Lundgren, A., Simrén, M., & Sjövall, H. (2005) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(05)00410-6 · Cited by 98 · see citing works
Sivro, A., Schuetz, A., Sheward, D., Joag, V., Yegorov, S., Liebenberg, L. J., Yende-Zuma, N., Stalker, A., Mwatelah, R. S., Selhorst, P., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aam6354 · Cited by 94 · see citing works
L-selectin can facilitate metastasis to lymph nodes in a transgenic mouse model of carcinogenesis
Qian, F., Hanahan, D., & Weissman, I. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061633698 · Cited by 80 · see citing works
Self-citationOrigin, trafficking, and intraepithelial fate of gut-tropic T cells
Guy-Grand, D., Vassalli, P., Eberl, G., Pereira, P., Burlen-Defranoux, O., Lemaitre, F., Di Santo, J. P., Freitas, A. A., Cumano, A., & Bandeira, A. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20122588 · Cited by 78 · see citing works
Mechanisms of MAdCAM-1 gene expression in human intestinal microvascular endothelial cells
Ogawa, H., Binion, D. G., Heidemann, J., Theriot, M., Fisher, P. J., Johnson, N. A., Otterson, M. F., & Rafiee, P. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00406.2003 · Cited by 68 · see citing works
Neumann, K., Kruse, N., Szilagyi, B., Erben, U., Rudolph, C., Flach, A., Zeitz, M., Hamann, A., & Klugewitz, K. (2012) · Hepatology · doi:10.1002/hep.24816 · Cited by 39 · see citing works
Self-citationOhmichi, Y., Hirakawa, J., Imai, Y., Fukuda, M., & Kawashima, H. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20101786 · Cited by 30 · see citing works
Krieg, C., Maier, R., & Meyerhans, A. (2004) · Journal of General Virology · doi:10.1099/vir.0.79919-0 · Cited by 24 · see citing works
Otte, F., Zhang, Y., Spagnuolo, J., Thielen, A., Däumer, M., Wiethe, C., Stoeckle, M., Kusejko, K., Klein, F., Metzner, K. J., et al. (2023) · Cell Reports Methods · doi:10.1016/j.crmeth.2023.100485 · Cited by 4 · see citing works
- Authors
- Berlin, C., Berg, E. L., Briskin, M. J., Andrew, D. P., Kilshaw, P. J., Holzmann, B., Weissman, I. L., Hamann, A., & Butcher, E. C.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- United States Department of Veterans Affairs (US)
- Stanford Medicine (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1993-07
- Volume
- 74
- Issue
- 1
- Pages
- 185-195
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2085875957
- Cited by
- 1,453
- References
- 0
- Citations by year
- 2026: 22 · 2025: 23 · 2024: 37 · 2023: 43 · 2022: 29 · 2021: 34 · 2020: 41 · 2019: 38 · 2018: 41 · 2017: 38 · 2016: 26 · 2015: 46 · 2014: 33 · 2013: 38 · 2012: 29
- FWCI
- 20.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2r01ai019957-07, 1r01dk045448-01)
- National Institute of General Medical Sciences (GM-37734)
- National Institute of Allergy and Infectious Diseases (AI 19957)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-45448)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Keywords
- alpha4beta7 integrin, MAdCAM-1, lymphocyte homing, lymphocyte adhesion, Peyer's patches, intestinal lamina propria, integrin activation, VCAM-1, alpha4beta1 integrin, LFA-1, immunoglobulin superfamily adhesion molecules, lymphocyte migration
- MeSH terms
- Animals, Antibodies, Monoclonal, Antigens, Neoplasm, Binding Sites, Cell Line, Humans, Immunoglobulins, Lymphocytes, Mucoproteins, Tumor Cells, Cultured, Cell Adhesion Molecules, Integrins, Vascular Cell Adhesion Molecule-1, Integrin alpha4beta1, Integrin beta Chains, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
