The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Functional domains of GABAA receptors
Open accessAbstract
The transmitter-gated ion channels mediate rapid synaptic transmission, for example, at the neuromuscular junction using acetylcholine and in the CNS using primarily the amino acids glutamate and GABA. GABAA-receptor Cl- channels share sequence homology with a superfamily of these channels including nicotinic acetylcholine receptor and inhibitory glycine receptor. In this article, Geoffrey Smith and Richard Olsen discuss recent affinity labelling and site-directed mutagenesis studies on GABAA receptors that have identified amino acid residues essential for binding of agonists and allosteric modulators as well as the ion channel wall formation. The structural domains identified are consistent with results obtained with other members of the transmitter-gated ion channel superfamily and suggest that structural models for one member of the family may apply to the others as well.
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Cites
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Self-citationSequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family
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Self-citationType I and Type II GABA A -Benzodiazepine Receptors Produced in Transfected Cells
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A point mutation in a Drosophila GABA receptor confers insecticide resistance
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Cited by
Macdonald, R. L., & Olsen, R. W. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.003033 · Cited by 1,975
Self-citationOlsen, R. W., & Sieghart, W. (2008) · Pharmacological Reviews · doi:10.1124/pr.108.00505 · Cited by 1,064
Self-citationGABAA receptors: Subtypes provide diversity of function and pharmacology
Olsen, R. W., & Sieghart, W. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.045 · Cited by 982
Self-citationAllosteric binding sites on cell-surface receptors: novel targets for drug discovery
Christopoulos, A. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd746 · Cited by 664
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Self-citation
Metadata
- Authors
- Smith, G. B., & Olsen, R. W.
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 1995-05
- Volume
- 16
- Issue
- 5
- Pages
- 162-168
- ISSN
- 0165-6147 (ISSN-L)
- OpenAlex
- W2067237230
- Cited by
- 489
- References
- 37
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
