The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Type I and Type II GABA A -Benzodiazepine Receptors Produced in Transfected Cells
Open accessAbstract
GABA A (γ-aminobutyric acid A)-benzodiazepine receptors expressed in mammalian cells and assembled from one of three different α subunit variants (α 1 , α 2 , or α 3 ) in combination with a β 1 and a γ 2 subunit display the pharmacological properties of either type I or type II receptor subtypes. These receptors contain high-affinity binding sites for benzodiazepines. However, CL 218 872, 2-oxoquazepam, and methyl β-carboline-3-carboxylate (β-CCM) show a temperature-modulated selectivity for α 1 subunit-containing receptors. There were no significant differences in the binding of clonazepam, diazepam, Ro 15-1788, or dimethoxy-4-ethyl-β-carboline-3-carboxylate (DMCM) to all three recombinant receptors. Receptors containing the α 3 subunit show greater GABA potentiation of benzodiazepine binding than receptors containing the α 1 or α 2 subunit, indicating that there are subtypes within the type II class. Thus, diversity in benzodiazepine pharmacology is generated by heterogeneity of the α subunit of the GABA A receptor.
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Cites
Yung-Chi, C., & Prusoff, W. H. (1973) · Biochemical Pharmacology · doi:10.1016/0006-2952(73)90196-2 · Cited by 12,922
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Self-citationMacdonald, R. L., & Olsen, R. W. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.003033 · Cited by 1,975
A Family of AMPA-Selective Glutamate Receptors
Keinänen, K., Wisden, W., Sommer, B., Werner, P., Herb, A., Verdoorn, T. A., Sakmann, B., & Seeburg, P. H. (1990) · Science · doi:10.1126/science.2166337 · Cited by 1,479
Self-citationFritschy, J., & Mohler, H. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903590111 · Cited by 1,244
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Metadata
- Authors
- Pritchett, D. B., Lüddens, H., & Seeburg, P. H.
- Venue
- Science
- Published
- 1989-09-22
- Volume
- 245
- Issue
- 4924
- Pages
- 1389-1392
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2059864318
- Cited by
- 717
- References
- 1
- FWCI
- 21.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Pritchett, D. B., Lüddens, H., & Seeburg, P. H. (1989). Type I and Type II GABA A -Benzodiazepine Receptors Produced in Transfected Cells. Science. https://doi.org/10.1126/science.2551039
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
