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Cited by 443

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Mechanisms of programmed cell death in the developing brain

Open access
Kuan, Chia-Yi, Roth, Kevin A., Flavell, Richard A., Rakic, Pasko·2000·Trends in Neurosciences

Abstract

Programmed cell death (apoptosis) is an important mechanism that determines the size and shape of the vertebrate nervous system. Recent gene-targeting studies have indicated that homologs of the cell-death pathway in the nematode Caenorhabditis elegans have analogous functions in apoptosis in the developing mammalian brain. However, epistatic genetic analysis has revealed that the apoptosis of progenitor cells during early embryonic development and apoptosis of postmitotic neurons at later stage of brain development have distinct roles and mechanisms. These results provide new insight on the significance and mechanism of neural cell death in mammalian brain development.

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Crossref · 10.1016/s0166-2236(00)01581-2

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Metadata

Authors
Kuan, C.-Y., Roth, K. A., Flavell, R. A., & Rakic, P.
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2000-07
Volume
23
Issue
7
Pages
291-297
ISSN
0166-2236 (ISSN-L)
OpenAlex
W1966492450
Cited by
443
References
4
FWCI
1.70
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Mechanisms of programmed cell death in the developing brain. https://app.cochat.ai/papers/10.1016/s0166-2236(00)01581-2
The paper
Kuan, C.-Y., Roth, K. A., Flavell, R. A., & Rakic, P. (2000). Mechanisms of programmed cell death in the developing brain. Trends in Neurosciences. https://doi.org/10.1016/s0166-2236(00)01581-2

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.