Ubiquitin, cellular inclusions and their role in neurodegeneration

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., & Shimizu, N. (1998) · Nature · doi:10.1038/33416 · Cited by 5,227 · see citing works

STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES

Coux, O., Tanaka, K., & Goldberg, A. L. (1996) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.65.070196.004101 · Cited by 2,438 · see citing works

Formation of Neuronal Intranuclear Inclusions Underlies the Neurological Dysfunction in Mice Transgenic for the HD Mutation

Davies, S. W., Turmaine, M., Cozens, B. A., DiFiglia, M., Sharp, A. H., Ross, C. A., Scherzinger, E., Wanker, E. E., Mangiarini, L., & Bates, G. P. (1997) · Cell · doi:10.1016/s0092-8674(00)80513-9 · Cited by 2,188 · see citing works

UBIQUITIN-DEPENDENT PROTEIN DEGRADATION

Hochstrasser, M. (1996) · Annual Review of Genetics · doi:10.1146/annurev.genet.30.1.405 · Cited by 1,695 · see citing works

UBE3A/E6-AP mutations cause Angelman syndrome

Kishino, T., Lalande, M., & Wagstaff, J. E. (1997) · Nature Genetics · doi:10.1038/ng0197-70 · Cited by 1,304 · see citing works

Huntingtin-Encoded Polyglutamine Expansions Form Amyloid-like Protein Aggregates In Vitro and In Vivo

Scherzinger, E., Lurz, R., Turmaine, M., Mangiarini, L., Hollenbach, B., Hasenbank, R., Bates, G. P., Davies, S. W., Lehrach, H., & Wanker, E. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80514-0 · Cited by 1,291 · see citing works

Protein ubiquitination involving an E1–E2–E3 enzyme ubiquitin thioester cascade

Scheffner, M., Nuber, U. A., & Huibregtse, J. M. (1995) · Nature · doi:10.1038/373081a0 · Cited by 1,017 · see citing works

De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome

Matsuura, T., Sutcliffe, J. S., Fang, P., Galjaard, R. H., Jiang, Y., Benton, C. S., Rommens, J. M., & Beaudet, A. L. (1997) · Nature Genetics · doi:10.1038/ng0197-74 · Cited by 858 · see citing works

Ubiquitin Is a Component of Paired Helical Filaments in Alzheimer's Disease

Mori, H., Kondo, J., & Ihara, Y. (1987) · Science · doi:10.1126/science.3029875 · Cited by 843 · see citing works

Intranuclear Inclusions of Expanded Polyglutamine Protein in Spinocerebellar Ataxia Type 3

Paulson, H. L., Perez, M. K., Trottier, Y., Trojanowski, J. Q., Subramony, S. H., Das, S. S., Vig, P. J. S., Mandel, J., Fischbeck, K. H., & Pittman, R. N. (1997) · Neuron · doi:10.1016/s0896-6273(00)80943-5 · Cited by 830 · see citing works

A Transmembrane Form of the Prion Protein in Neurodegenerative Disease

Hegde, R. S., Mastrianni, J. A., Scott, M. R. D., DeFea, K., Tremblay, P. J., Torchia, M., DeArmond, S. J., Prusiner, S. B., & Lingappa, V. R. (1998) · Science · doi:10.1126/science.279.5352.827 · Cited by 730 · see citing works

Regulation of ubiquitin‐dependent processes by deubiquitinating enzymes

Wilkinson, K. D. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.14.9409543 · Cited by 575 · see citing works

Frameshift Mutants of β Amyloid Precursor Protein and Ubiquitin-B in Alzheimer's and Down Patients

van Leeuwen, F. W., de Kleijn, D. P. V., van den Hurk, H., Neubauer, A., Sonnemans, M. A. F., Sluijs, J. A., Köycü, S., Ramdjielal, R. D. J., Salehi, A., Martens, G. J. M., et al. (1998) · Science · doi:10.1126/science.279.5348.242 · Cited by 561 · see citing works

Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodies in muscle, and mallory bodies in alcoholic liver disease

Lowe, J., Blanchard, A., Morrell, K., Lennox, G., Reynolds, L., Billett, M., Landon, M., & Mayer, R. J. (1988) · The Journal of Pathology · doi:10.1002/path.1711550105 · Cited by 539 · see citing works

The multicatalytic proteinase complex, a major extralysosomal proteolytic system

Orłowski, M. (1990) · Biochemistry · doi:10.1021/bi00497a001 · Cited by 459 · see citing works

Proteolysis in Cultured Liver Epithelial Cells during Oxidative Stress

Grune, T., Reinheckel, T., Joshi, M., & Davies, K. J. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.5.2344 · Cited by 407 · see citing works

Heat shock proteins: the search for functions.

Schlesinger, M. J. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.103.2.321 · Cited by 396 · see citing works

Ectopically Expressed CAG Repeats Cause Intranuclear Inclusions and a Progressive Late Onset Neurological Phenotype in the Mouse

Ordway, J. M., Tallaksen‐Greene, S. J., Gutekunst, C., Bernstein, E. M., Cearley, J. A., Wiener, H. W., Dure, L. S., Lindsey, R., Hersch, S. M., Jope, R. S., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80464-x · Cited by 370 · see citing works

Targeting of substrates to the 26S proteasome

Pickart, C. M. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.13.9367341 · Cited by 367 · see citing works

Ubiquitin carboxyl‐terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases

Lowe, J. S., McDermott, H., Landon, M., Mayer, R. J., & Wilkinson, K. D. (1990) · The Journal of Pathology · doi:10.1002/path.1711610210 · Cited by 359 · see citing works

Modification of protein surface hydrophobicity and methionine oxidation by oxidative systems

Chao, C., Ma, Y.-S., & Stadtman, E. R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.2969 · Cited by 336 · see citing works

Ubiquitin‐dependent internalization and down‐regulation of plasma membrane proteins

Hicke, L. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.14.9409540 · Cited by 271 · see citing works

Resistance to cadmium mediated by ubiquitin-dependent proteolysis

Jungmann, J., Reins, H., Schobert, C., & Jentsch, S. (1993) · Nature · doi:10.1038/361369a0 · Cited by 261 · see citing works

The dynamic state of heat shock proteins in chicken embryo fibroblasts.

Collier, N. C., & Schlesinger, M. J. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.103.4.1495 · Cited by 234 · see citing works

Amyloid β-Protein Inhibits Ubiquitin-dependent Protein Degradation in Vitro

Gregori, L. L., Fuchs, C., Figueiredo‐Pereira, M. E., Nostrand, W. E. V., & Goldgaber, D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.34.19702 · Cited by 232 · see citing works

Activity of Ubiquitin-dependent Pathway in Response to Oxidative Stress

Shang, F., Gong, X., & Taylor, A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.37.23086 · Cited by 231 · see citing works

Immunocytochemical Co-localization of the Proteasome in Ubiquitinated Structures in Neurodegenerative Diseases and the Elderly

Ii, K., Ito, H., Tanaka, K., & Hirano, A. (1997) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199702000-00002 · Cited by 215 · see citing works

Endoproteolytic Cleavage and Proteasomal Degradation of Presenilin 2 in Transfected Cells

Kim, T., Pettingell, W. H., Hallmark, O. G., Moir, R. D., Wasco, W., & Tanzi, R. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.17.11006 · Cited by 208 · see citing works

Disruption of the Intracellular Sulfhydryl Homeostasis by Cadmium-induced Oxidative Stress Leads to Protein Thiolation and Ubiquitination in Neuronal Cells

Figueiredo‐Pereira, M. E., Yakushin, S., & Cohen, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.21.12703 · Cited by 184 · see citing works

A New Inhibitor of the Chymotrypsin‐Like Activity of the Multicatalytic Proteinase Complex (20S Proteasome) Induces Accumulation of Ubiquitin‐Protein Conjugates in a Neuronal Cell

Figueiredo‐Pereira, M. E., Berg, K. A., & Wilk, S. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63041578.x · Cited by 182 · see citing works

Subpopulations of proteasomes in rat liver nuclei, microsomes and cytosol

Palmer, A., Rivett, A. J., Thomson, S., Hendil, K. B., Butcher, G. W., Fuertes, G., & Knecht, E. (1996) · Biochemical Journal · doi:10.1042/bj3160401 · Cited by 171 · see citing works

Structural Neurology: Are Seeds at the Root of Neuronal Degeneration?

Lansbury, P. T. (1997) · Neuron · doi:10.1016/s0896-6273(00)80406-7 · Cited by 169 · see citing works

Oxidative stress and recovery from oxidative stress are associated with altered ubiquitin conjugating and proteolytic activities in bovine lens epithelial cells

Shang, F., & Taylor, A. (1995) · Biochemical Journal · doi:10.1042/bj3070297 · Cited by 157 · see citing works

Structure of Tetraubiquitin Shows How Multiubiquitin Chains Can Be Formed

Cook, W. J., Jeffrey, L. C., Kasperek, E. M., & Pickart, C. M. (1994) · Journal of Molecular Biology · doi:10.1006/jmbi.1994.1169 · Cited by 156 · see citing works

Binding of Amyloid β Protein to the 20 S Proteasome

Gregori, L. L., Hainfeld, J. F., Simon, M. N., & Goldgaber, D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.1.58 · Cited by 151 · see citing works

E-4-hydroxy-2-nonenal is cytotoxic and cross-links cytoskeletal proteins in P19 neuroglial cultures.

Montine, T. J., Amarnath, K., Martin, M. E., Strittmatter, W. J., & Graham, D. G. (1996) · Europe PMC (PubMed Central) · Cited by 136 · see citing works

Oxidative stress, mutant SOD1, and neurofilament pathology in transgenic mouse models of human motor neuron disease.

Tu, P., Gurney, M. E., Julien, J., Lee, V. M. ‐., & Trojanowski, J. Q. (1997) · PubMed · Cited by 115 · see citing works

The awakening of α-synuclein

Goedert, M. (1997) · Nature · doi:10.1038/40767 · Cited by 95 · see citing works

Impairment of protein ubiquitination may cause delayed neuronal death

Magnusson, K., & Wieloch, T. W. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90389-3 · Cited by 95 · see citing works

Polyubiquitin gene expression contributes to oxidative stress resistance in respiratory yeast (Saccharomyces cerevisiae)

Cheng, L., Watt, R., & Piper, P. W. (1994) · Molecular and General Genetics MGG · doi:10.1007/bf00301072 · Cited by 82 · see citing works

Alzheimer disease: correlation of cerebro-spinal fluid and brain ubiquitin levels

Kudo, T., Iqbal, K., Ravid, R., Swaab, D. F., & Grundke, I. (1994) · Brain Research · doi:10.1016/0006-8993(94)91757-4 · Cited by 75 · see citing works

Expression of Polyubiquitin and Heat‐Shock Protein 70 Genes Increases in the Later Stages of Disease Progression in Scrapie‐Infected Mouse Brain

Kenward, N., Hope, J., Landon, M., et al. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.62051870.x · Cited by 65 · see citing works

Synthetic Signals for Ubiquitin-Dependent Proteolysis

Sadis, S., Atienza, C. A., & Finley, D. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.8.4086 · Cited by 63 · see citing works

Anomalous accumulation of τ and ubiquitin immunoreactivities in rat brain caused by protease inhibition and by normal aging: a clue to PHF pathogenesis?

Ivy, G. O., Kitani, K., & Ihara, Y. (1989) · Brain Research · doi:10.1016/0006-8993(89)91117-7 · Cited by 62 · see citing works

The Prosomes (Multicatalytic Proteinases; Proteasomes) and Their Relationship to the Untranslated Messenger Ribonucleoproteins, the Cytoskeleton, and Cell Differentiation

Scherrer, K., & Fayçal, B. E. Y. (1994) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)60047-1 · Cited by 60 · see citing works

Structural basis of dementia in neurodegenerative disorders

Jellinger, K. A. (1996) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6892-9_1 · Cited by 54 · see citing works

Activation of the Multicatalytic Endopeptidase by Oxidants. Effects on Enzyme Structure

Strack, P. R., Waxman, L., & Fagan, J. M. (1996) · Biochemistry · doi:10.1021/bi9518048 · Cited by 54 · see citing works

Polyglutamines, nuclear inclusions and neurodegeneration

Lunkes, A., & Mandel, J. (1997) · Nature Medicine · doi:10.1038/nm1197-1201 · Cited by 52 · see citing works

Endosome-Lysosomes, Ubiquitin and Neurodegeneration

Mayer, R. J., Tipler, C., Arnold, J., László, L., Al-Khedhairy, A. A., Lowe, J. S., & Landon, M. (1996) · Advances in experimental medicine and biology · doi:10.1007/978-1-4613-0335-0_33 · Cited by 46 · see citing works

Changes in proteasome activity following transient ischemia

Kamikubo, T., & Hayashi, T. (1996) · Neurochemistry International · doi:10.1016/0197-0186(95)00071-2 · Cited by 45 · see citing works

Protein degradation: The ins and outs of the matter

Cresswell, P., & Hughes, E. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00279-x · Cited by 33 · see citing works

Changes in Heat Shock Protein 70 and Ubiquitin mRNA Levels in C1300 N2A Mouse Neuroblastoma Cells Following Treatment with Iron

Uney, J. B., Anderton, B. H., & Thomas, S. M. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03198.x · Cited by 27 · see citing works

Effects of acute lithium administration on conditioned avoidance behavior and monoamine synthesis in rats

Berggren, U., Ahlenius, S., & Engel, J. (1980) · Journal of Neural Transmission · doi:10.1007/bf01256634 · Cited by 26 · see citing works

Ubiquitin and the molecular pathology of chronic degenerative diseases

Mayer, R. J., Lowe, J. S., & Landon, M. (1991) · The Journal of Pathology · doi:10.1002/path.1711630402 · Cited by 22 · see citing works

Age-related ubiquitin-positive granular structures in non-demented subjects and neurodegenerative disorders

Iseki, E., Odawara, T., Li, F., Kosaka, K., Nishimura, T., Akiyama, H., & Ikeda, K. (1996) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(96)00024-x · Cited by 22 · see citing works

On the spatial organization of ubiquitin-dependent proteolysis in HeLa cells.

Wójcik, C. (1997) · PubMed · Cited by 18 · see citing works

Amyloid beta precursor protein and ubiquitin epitopes in human and experimental dystrophic axons. Ultrastructural localization.

Bacci, B., Cochran, E., Nunzi, M. G., Izeki, E., Mizutani, T., Patton, A., Hite, S., Lm, S., AUTILIO‐GAMBETTI, L., & Gambetti, P. L. (1994) · PubMed Central · Cited by 12 · see citing works

Increased phosphorylation of neurofilament subunits in PC12 cells and rat dorsal root ganglion neurons treated with N‐Acetyl‐Leu‐Leu‐norleucinal

Jayaraman, D., Giasson, B. I., & Mushynski, W. E. (1995) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(95)00060-7 · Cited by 8 · see citing works

Anti-ubiquitin immunoreactivity associates with pyramidal cell death induced by intraventricular infusion of leupeptin in rat hippocampus

Okada, M., Miyake, T., Kitamura, T., et al. (1994) · Neuroscience Research · doi:10.1016/0168-0102(94)90008-6 · Cited by 7 · see citing works

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

Shimura, H., Hattori, N., Kubo, S.-I., Mizuno, Y., Asakawa, S., Minoshima, S., Shimizu, N., Iwai, K., Chiba, T., Tanaka, K., et al. (2000) · Nature Genetics · doi:10.1038/77060 · Cited by 2,024 · see citing works

Myocytes Die by Multiple Mechanisms in Failing Human Hearts

Kostin, S., Pool, L., Elsässer, A., Hein, S., Drexler, H. C. A., Arnon, E., Hayakawa, Y., Zimmermann, R., Bauer, E., Klövekorn, W.-P., et al. (2003) · Circulation Research · doi:10.1161/01.res.0000067471.95890.5c · Cited by 564 · see citing works

Autophagy and ALS: mechanistic insights and therapeutic implications

Chua, J. P., De Calbiac, H., Kabashi, E., & Barmada, S. J. (2022) · Autophagy · doi:10.1080/15548627.2021.1926656 · Cited by 189 · see citing works

Ubiquitin-Binding Protein p62 Expression Is Induced during Apoptosis and Proteasomal Inhibition in Neuronal Cells

Kuusisto, E., Suuronen, T., & Salminen, A. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.4107 · Cited by 131 · see citing works

Dendritic spine loss and neurodegeneration is rescued by Rab11 in models of Huntington's disease

Richards, P., Didszun, C., Campesan, S., Simpson, A., Horley, B., Young, K. W., Glynn, P., Cain, K., Kyriacou, C. P., Giorgini, F., et al. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2010.127 · Cited by 82 · see citing works

The interrelationship of proteasome impairment and oligomeric intermediates in neurodegeneration

Deger, J. M., Gerson, J. E., & Kayed, R. (2015) · Aging Cell · doi:10.1111/acel.12359 · Cited by 69 · see citing works

Rho GTPases in neurodegeneration diseases

DeGeer, J., & Lamarche-Vane, N. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.06.016 · Cited by 46 · see citing works

Selective autophagy: ubiquitin-mediated recognition and beyond

Kraft, C., Peter, M., & Hofmann, K. (2010) · Nature Cell Biology · doi:10.1038/ncb0910-836 · Cited by 639 · see citing works

Emerging Paradigm of Crosstalk between Autophagy and the Ubiquitin-Proteasome System.

Nam, T., Han, J. H., Devkota, S., & Lee, H. (2017) · Europe PMC (PubMed Central) · doi:10.14348/molcells.2017.0226 · Cited by 107 · see citing works

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS.

Pandey, U. B., Nie, Z., Batlevi, Y., McCray, B. A., Ritson, G. P., Nedelsky, N. B., Schwartz, S. L., DiProspero, N. A., Knight, M. A., Schuldiner, O., et al. (2007) · Nature · doi:10.1038/nature05853 · Cited by 1,234 · see citing works

Ubiquitination-Proteasome System (UPS) and Autophagy Two Main Protein Degradation Machineries in Response to Cell Stress

Li, Y., Li, S., & Wu, H. (2022) · Cells · doi:10.3390/cells11050851 · Cited by 384 · see citing works

Ubiquitin proteasome system as a pharmacological target in neurodegeneration

Hol, E. M., Fischer, D. F., Ovaa, H., et al. (2006) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.6.9.1337 · Cited by 32 · see citing works