Rho GTPases in neurodegeneration diseases

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

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The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

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Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

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The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

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RHO GTPASES: Biochemistry and Biology

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Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

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Molecular Pathways of Neurodegeneration in Parkinson's Disease

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Signaling from Rho to the Actin Cytoskeleton Through Protein Kinases ROCK and LIM-kinase

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UNRAVELING THE MECHANISMS INVOLVED IN MOTOR NEURON DEGENERATION IN ALS

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The Interaction between N-WASP and the Arp2/3 Complex Links Cdc42-Dependent Signals to Actin Assembly

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Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization

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Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

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The role of the Rho GTPases in neuronal developmentPreprint

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Neuropathological assessment of Parkinson’s disease: refining the diagnostic criteria

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Genetic and clinical aspects of Charcot‐Marie‐Tooth's disease

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p75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp

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A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis

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The trip of the tip: understanding the growth cone machinery

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Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation

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Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex

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Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

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A century-old debate on protein aggregation and neurodegeneration enters the clinic

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Rho Kinase Inhibition Enhances Axonal Regeneration in the Injured CNS

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Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

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Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins.Preprint

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Inhibition of Myosin Light Chain Kinase by p21-Activated Kinase

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mDia mediates Rho-regulated formation and orientation of stable microtubules

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Peripheral Neuropathy

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Rac and Cdc42 Induce Actin Polymerization and G1 Cell Cycle Progression Independently of p65PAK and the JNK/SAPK MAP Kinase Cascade

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Signal Transduction in Neuronal Migration

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Rho-associated Kinase ROCK Activates LIM-kinase 1 by Phosphorylation at Threonine 508 within the Activation Loop

Ohashi, K., Nagata, K., Maekawa, M., Ishizaki, T., Narumiya, S., & Mizuno, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.5.3577 · Cited by 533 · see citing works

PirB is a Functional Receptor for Myelin Inhibitors of Axonal Regeneration

Atwal, J. K., Pinkston-Gosse, J., Syken, J., Stawicki, S. S., Wu, Y., Shatz, C. J., & Tessier‐Lavigne, M. (2008) · Science · doi:10.1126/science.1161151 · Cited by 503 · see citing works

Rho Guanine Dissociation Inhibitors

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Current knowledge of the large RhoGAP family of proteins

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The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI

Yamashita, T., & Tohyama, M. (2003) · Nature Neuroscience · doi:10.1038/nn1045 · Cited by 460 · see citing works

Aggresomes Formed by α-Synuclein and Synphilin-1 Are Cytoprotective

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Post-translational modifications of p21rho proteins.

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Nogo-A and Myelin-Associated Glycoprotein Mediate Neurite Growth Inhibition by Antagonistic Regulation of RhoA and Rac1

Niederöst, B. P., Oertle, T., Fritsche, J., McKinney, R. A., & Bandtlow, C. E. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10368.2002 · Cited by 415 · see citing works

Dbl family guanine nucleotide exchange factors

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Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1

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Ubiquitin, cellular inclusions and their role in neurodegeneration

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A TNF Receptor Family Member, TROY, Is a Coreceptor with Nogo Receptor in Mediating the Inhibitory Activity of Myelin Inhibitors

Park, J. B., Yiu, G. C., Kaneko, S., Wang, J., Chang, J., & He, Z. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.040 · Cited by 388 · see citing works

A microRNA-based gene dysregulation pathway in Huntington's disease

Johnson, R., Zuccato, C., Belyaev, N. D., Guest, D. J., Cattaneo, E. F., & Buckley, N. J. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.11.001 · Cited by 360 · see citing works

Hereditary motor and sensory neuropathies.

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RhoE Binds to ROCK I and Inhibits Downstream Signaling

Riento, K., Guasch, R., Garg, R., Jin, B.-Q., & Ridley, A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.12.4219-4229.2003 · Cited by 324 · see citing works

Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease

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Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß ₄₂ by Inhibiting Rho

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VAV proteins as signal integrators for multi-subunit immune-recognition receptors

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Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice

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ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics

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Rnd Proteins Function as RhoA Antagonists by Activating p190 RhoGAP

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Developmental axon pruning mediated by BDNF-p75NTR–dependent axon degeneration

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A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling

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Rac-PAK Signaling Stimulates Extracellular Signal-Regulated Kinase (ERK) Activation by Regulating Formation of MEK1-ERK Complexes

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Suppression of Rho-kinase activity promotes axonal growth on inhibitory CNS substrates

Borisoff, J., Chan, C. C. M., Hiebert, G. W., Oschipok, L. W., Robertson, G. S., Zamboni, R. J., Steeves, J. D., & Tetzlaff, W. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(02)00032-5 · Cited by 210 · see citing works

Rac1 and Cdc42 but Not RhoA or Rho Kinase Activities Are Required for Neurite Outgrowth Induced by the Netrin-1 Receptor DCC (Deleted in Colorectal Cancer) in N1E-115 Neuroblastoma Cells

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The β-amyloid protein of Alzheimer's disease increases neuronal CRMP-2 phosphorylation by a Rho-GTP mechanism

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WASP and SCAR/WAVE proteins: the drivers of actin assembly

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Cdc42-interacting Protein 4 Mediates Binding of the Wiskott-Aldrich Syndrome Protein to Microtubules

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Hereditary Motor and Sensory Neuropathies

Schröder, J. M. (2001) · Springer eBooks · doi:10.1007/978-3-642-56808-4_7 · Cited by 174 · see citing works

Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation

Shao, J., Welch, W. J., DiProspero, N. A., & Diamond, M. I. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00079-08 · Cited by 171 · see citing works

Identification of Epigenetically Altered Genes in Sporadic Amyotrophic Lateral Sclerosis

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A rapid cellular FRET assay of polyglutamine aggregation identifies a novel inhibitor

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ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo

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Peripheral nerve demyelination caused by a mutant Rho GTPase guanine nucleotide exchange factor, frabin/FGD4.

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Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain

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A Role for Nogo Receptor in Macrophage Clearance from Injured Peripheral Nerve

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Hereditary Motor and Sensory Neuropathy

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Rac1 Protein Rescues Neurite Retraction Caused by G2019S Leucine-rich Repeat Kinase 2 (LRRK2)

Chan, D., Citro, A., Cordy, J. M., Shen, G. C., & Wolozin, B. L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.234005 · Cited by 120 · see citing works

Slowed Conduction and Thin Myelination of Peripheral Nerves Associated with Mutant Rho Guanine-Nucleotide Exchange Factor 10

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Nitric Oxide as an Initiator of Brain Lesions During the Development of Alzheimer Disease

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p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain

Park, K. J., Ayala‐Grosso, C. A., Aubert, I., Kaplan, D. R., & Miller, F. D. (2010) · Nature Neuroscience · doi:10.1038/nn.2513 · Cited by 111 · see citing works

Aβ1-42 stimulates actin polymerization in hippocampal neurons through Rac1 and Cdc42 Rho GTPases

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Actin Polymerization Is Essential for Myelin Sheath Fragmentation during Wallerian Degeneration

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A Rac1/Phosphatidylinositol 3-Kinase/Akt3 Anti-apoptotic Pathway, Triggered by AlsinLF, the Product of the ALS2 Gene, Antagonizes Cu/Zn-superoxide Dismutase (SOD1) Mutant-induced Motoneuronal Cell Death

Kanekura, K., Hashimoto, Y., Kita, Y. A., Sasabe, J., Aiso, S., Nishimoto, I., & Matsuoka, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410508200 · Cited by 99 · see citing works

The Nuclear Factor κB–Activator Gene PLEKHG5 Is Mutated in a Form of Autosomal Recessive Lower Motor Neuron Disease with Childhood Onset

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Trio Is a Key Guanine Nucleotide Exchange Factor Coordinating Regulation of the Migration and Morphogenesis of Granule Cells in the Developing Cerebellum

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Transgenic mice overexpressing XIAP in neurons show better outcome after transient cerebral ischemia

Trapp, T., Korhonen, L., Besselmann, M., Maza, R. M., MERCER, E. A. J., & Lindholm, D. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00013-7 · Cited by 89 · see citing works

ALS2/Alsin Regulates Rac-PAK Signaling and Neurite Outgrowth

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Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex

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Unstable mutants in the peripheral endosomal membrane component ALS2 cause early-onset motor neuron disease

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Altered distribution of RhoA in Alzheimer’s disease and AβPP overexpressing mice

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Cdc42-interacting protein 4 binds to huntingtin: Neuropathologic and biological evidence for a role in Huntington's disease

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Dock3 Stimulates Axonal Outgrowth via GSK-3β-Mediated Microtubule Assembly

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Progressive spinal axonal degeneration and slowness in ALS2‐deficient mice

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Isolation and Characterization of Novel Presenilin Binding Protein

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Myelin is dependent on the Charcot–Marie–Tooth Type 4H disease culprit protein FRABIN/FGD4 in Schwann cells

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VAV2 and VAV3 as Candidate Disease Genes for Spontaneous Glaucoma in Mice and Humans

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Loss of Modifier of Cell Adhesion Reveals a Pathway Leading to Axonal Degeneration

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Kalirin, a Key Player in Synapse Formation, Is Implicated in Human Diseases

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Lesional Expression of RhoA and RhoB following Traumatic Brain Injury in Humans

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RhoE Deficiency Produces Postnatal Lethality, Profound Motor Deficits and Neurodevelopmental Delay in Mice

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β-Amyloid Inhibits Protein Prenylation and Induces Cholesterol Sequestration by Impairing SREBP-2 Cleavage

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Molecular Mechanisms of Cytokine-Induced Neuroprotection: NFκB and Neuroplasticity

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The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42

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The Role of Kalirin9 in p75/Nogo Receptor-mediated RhoA Activation in Cerebellar Granule Neurons

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The RhoA GEF Syx Is a Target of Rnd3 and Regulated via a Raf1-Like Ubiquitin-Related Domain

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Presenilin Binding Protein Is Associated with Neurofibrillary Alterations in Alzheimer’s Disease and Stimulates Tau Phosphorylation

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Neuronal polarization is impaired in mice lacking RhoE expression

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Identification of a Negative Regulatory Region for the Exchange Activity and Characterization of T332I Mutant of Rho Guanine Nucleotide Exchange Factor 10 (ARHGEF10)

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Mutant Huntingtin Alters Cell Fate in Response to Microtubule Depolymerization via the GEF-H1-RhoA-ERK Pathway

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Increased RhoA Prenylation in the loechrig (loe) Mutant Leads to Progressive Neurodegeneration

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RhoE stimulates neurite‐like outgrowth in PC12 cells through inhibition of the RhoA/ROCK‐I signalling

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Involvement of EphB/Ephrin-B Signaling in Axonal Survival in Mouse Experimental Glaucoma

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A novel Rac1 GAP splice variant relays poly-Ub accumulation signals to mediate Rac1 inactivation

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Genetic response to DNA damage: Proapoptotic targets of RhoB include modules for p53 response and susceptibility to alzheimer’s disease

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Novel guanine nucleotide exchange factor GEFmeso of Drosophila melanogaster interacts with Ral and Rho GTPase Cdc42

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Altered apoptotic responses in neurons lacking RhoB GTPase

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The Guanine Nucleotide Exchange Factor Kalirin-7 Is a Novel Synphilin-1 Interacting Protein and Modifies Synphilin-1 Aggregate Transport and Formation

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Role of the Rho GTPase/Rho kinase signaling pathway in pathogenesis and treatment of glaucoma: Bench to bedside research

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Rho GTPases as therapeutic targets in Alzheimer’s disease

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RhoA Signaling in Neurodegenerative Diseases

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DNA Methylation Signatures of Depressive Symptoms in Middle-aged and Elderly Persons

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Microglia dysfunction caused by the loss of rhoa disrupts neuronal physiology and leads to neurodegeneration

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Modulation of actin dynamics by Rac1 to target cognitive function

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The role of transthyretin in cell biology: impact on human pathophysiology

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Leucine‐rich repeat kinase 2 interacts with p21‐activated kinase 6 to control neurite complexity in mammalian brain

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Dendritic spine actin cytoskeleton in autism spectrum disorder

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Rho GTPases in the Physiology and Pathophysiology of Peripheral Sensory Neurons

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Enhanced Neurite Outgrowth of Human Model (NT2) Neurons by Small-Molecule Inhibitors of Rho/ROCK Signaling

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White matter DNA methylation profiling reveals deregulation of HIP1, LMAN2, MOBP, and other loci in multiple system atrophy

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Pharmacological Modulators of Small GTPases of Rho Family in Neurodegenerative Diseases

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Chemotherapy-Induced Peripheral Neuropathy and Changes in Cytoskeleton

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Hsc70 chaperone activity underlies Trio GEF function in axon growth and guidance induced by netrin-1

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Regulating Rac in the Nervous System: Molecular Function and Disease Implication of Rac GEFs and GAPs

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Simultaneous and independent tuning of RhoA and Rac1 activity with orthogonally inducible promoters

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BordetellaDermonecrotic Toxin Is a Neurotropic Virulence Factor That Uses CaV3.1 as the Cell Surface Receptor

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Mutations in SPATA13/ASEF2 cause primary angle closure glaucoma

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RHO to the DOCK for GDP disembarking: Structural insights into the DOCK GTPase nucleotide exchange factors

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The role of Rho GTPase family in cochlear hair cells and hearing

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ANKS1B encoded AIDA-1 regulates social behaviors by controlling oligodendrocyte function

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Repurposing Small Molecules to Target PPAR-γ as New Therapies for Peripheral Nerve Injuries

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A mutation in the low-complexity domain of splicing factor hnRNPA1 linked to amyotrophic lateral sclerosis disrupts distinct neuronal RNA splicing networksPreprint

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Microexon alternative splicing of small GTPase regulators: Implication in central nervous system diseases

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The Mevalonate Pathway in Alzheimer’s Disease — Cholesterol and Non-Sterol Isoprenoids

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Photodynamic treatment modulates various GTPase and cellular signalling pathways in Tauopathy

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Differential serum microRNAs in premotor LRRK2 G2019S carriers from Parkinson’s disease

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Creutzfeldt-Jakob Disease Subtype-Specific Regional and Temporal Regulation of ADP Ribosylation Factor-1-Dependent Rho/MLC Pathway at Pre-Clinical Stage

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Down regulation of DNA topoisomerase IIβ exerts neurodegeneration like effect through Rho GTPases in cellular model of Parkinson’s disease by Down regulating tyrosine hydroxylase

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Posttranslational Modifications of Small G Proteins

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Exploring the Nerve Regenerative Capacity of Compounds with Differing Affinity for PPARγ In Vitro and In Vivo

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Targeting CRABP1 Signalosomes in Managing Neurodegeneration

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Cytoskeletal Organization: Actin

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Transthyretin interacts with actin regulators in a Drosophila model of familial amyloid polyneuropathy

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Dynamics of a Protein Interaction Network Associated to the Aggregation of polyQ-Expanded Ataxin-1

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Phosphoproteomics unveils the signaling dynamics in neuronal cells stimulated with insulin and insulin-like growth factors

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Small Molecule Improvement of Trafficking Defects in Models of Neurodegeneration

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Proteomics Analysis of Proteotoxic Stress Response in In-Vitro Human Neuronal Models

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Principles Driving the Spatial Organization of Rho GTPase Signaling at Synapses

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Progress in Research on the Mechanism and Treatment of Post-stroke Infection

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Biallelic variants in ARHGAP19 cause a progressive inherited motor-predominant neuropathy

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Aberrant Splicing Signatures Underpin Oligodendrocyte Damage in ALS and Neuron Loss in FTD

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Chronic fasudil treatment induces benzodiazepine-like tolerance via modulation of GABA-A receptor γ2 subunit expression and impairs contextual fear memory in mice

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Hippocampus undergoes transcriptomic changes and synaptic alterations in a Slc17a5 heterozygous mouse model with working memory deficit

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Herbal Bioactives Targeting Rho GTPases: A Multi-Targeted Strategy for Mitigating Neuroinflammation in Alzheimer’s and Parkinson’s Diseases

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Pharmacological Modulators of Small GTPases of Rho Family in Neurodegenerative Diseases

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Editorial: Rho family GTPases and their effectors in neuronal survival and neurodegeneration

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Small GTPases of the Ras and Rho Families Switch on/off Signaling Pathways in Neurodegenerative Diseases

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Rho family GTPases: Key players in neuronal development, neuronal survival, and neurodegeneration

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