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Cited by 59Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesSchizophrenia research and treatment

The effects of local application of D2 selective dopaminergic drugs into the medial prefrontal cortex of rats in a delayed spatial choice task

Druzin, Michael Y, Kurzina, Natalia P, Malinina, Evgenya P, Kozlov, Andrej P·2000·Behavioural Brain Research
DOI 10.1016/s0166-4328(99)00166-7
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Abstract

The study examined the effects of modulation of dopamine D2 receptors-mediated neurotransmission in the rat's prefrontal cortex (PFC) on storage and executive components of working memory. Rats were trained on delayed (delay interval, 3 s) and non-delayed choice in a U-maze. The prominence of proactive interference was evaluated by sorting errors in a current trial on the basis of animal reactions in a preceding trial. The erroneous runs to the same arm of the maze as in the previous trial were identified as the repetitions (RE) and the erroneous runs to the other arm in comparison with the previous trial were classified as alternations (AE). The bilateral microinfusion of D2 agonists PPHT (0.004 microg, 0.04 microg, 0.4 microg/1 microl) into medial wall of the PFC produced a dose-dependent increase in the error rate of the delayed-response task and did not influence non-delayed choice. In delay condition PPHT enhanced the perseverative tendencies (the rate of RE was significantly higher than the rate of AE), in non-delayed choice the erroneous performance was mainly represented by AE. In contrast, the infusion of D2-receptor antagonist sulpiride (0.03 microg, 0.3 microg, 3 microg/1 microl) increased the accuracy of delayed choice and changed the mode of intertrial dependence-rats made significantly more AE than RE. The results are discussed in terms of the involvement of D2 receptor dependent transmission of the PFC in different cognitive processes related to the delayed per…

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  • Excessive D2 receptor stimulation impairs prefrontal cortex working memory function in animals and humans and is associated with increased response-related firing in monkeys and increased response-related blood oxygen level-dependent signals in human imaging studies.

    “excessive D2 receptor stimulation impairs PFC working memory function in animals69 and humans70 and is associated with increased response-related firing in monkeys71 and increased response-related blood oxygen level-dependent signals in human imaging studies70.”

    From Stress signalling pathways that impair prefrontal cortex structure and function (2009) · cites this paper as [69]

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Authors
Druzin, M. Y., Kurzina, N. P., Malinina, E. P., & Kozlov, A. P.
Affiliations
  • Institute of Experimental Medicine (RU)
  • St Petersburg University (RU)
Corresponding author
Kozlov, Andrej P
ORCID
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2000-04
Volume
109
Issue
1
Pages
99-111
ISSN
0166-4328 (ISSN-L)
DOI
10.1016/s0166-4328(99)00166-7
OpenAlex
W2048148249
Cited by
59
References
2
Citations by year
2024: 2 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 6 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 2
FWCI
1.17
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
dopamine D2 receptor, medial prefrontal cortex, working memory, proactive interference, perseveration, sulpiride, microinfusion, executive function
MeSH terms
Animals, Brain Mapping, Choice Behavior, Dose-Response Relationship, Drug, Male, Mental Recall, Retention, Psychology, Dopamine Agents, Rats, Wistar, Prefrontal Cortex, Receptors, Dopamine D2, Maze Learning, Rats

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