D 2 dopamine receptors recruit a GABA component for their attenuation of excitatory synaptic transmission in the adult rat prefrontal cortex
Open accessAbstract
The dopamine modulation of neuronal excitability in the prefrontal cortex (PFC) changes during critical late periods of postnatal development. In particular, D 2 receptors activate fast‐spiking interneurons after, and not before, adolescence. To test the functional impact of this change, we investigated the effects of dopamine agonists on PFC excitatory synaptic transmission with whole‐cell recordings from deep‐layer pyramidal neurons in brain slices obtained from prepubertal [postnatal day (PD) 28–35] and postpubertal (PD > 51) rats. Electrical stimulation of superficial layers elicited a fast AMPA/kainate excitatory postsynaptic potential (EPSP). In the adult PFC, the D 2 agonist quinpirole decreased EPSP amplitude, an effect that lasted for at least 25 min after drug washout and was blocked by the D 2 antagonist eticlopride. The late component of this effect was blocked by the GABA‐A antagonist picrotoxin without affecting the early inhibition. Quinpirole also decreased EPSP amplitude in deep‐layer pyramidal neurons from prepubertal rats, but this response was not affected by picrotoxin. A D 1 agonist, on the other hand, did not affect the pyramidal neuron EPSP. These results indicate that D 2 , not D 1 , receptors attenuate local excitatory synaptic transmission in the adult PFC, and this effect of D 2 involves a recruitment of local GABAergic activity. Synapse 61:843–850, 2007. © 2007 Wiley‐Liss, Inc.
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Prior to adolescence, D2 stimulation elicits either no effect or only weak inhibition on interneurons; in adult animals, stimulation of D2 receptors is strongly excitatory and results in robust firing of interneurons and potent inhibition of their pyramidal cell targets.
“Prior to adolescence, D2 stimulation elicits either no effect or only weak inhibition on interneurons. However, in adult animals stimulation of D2 receptors is strongly excitatory and therefore results in robust firing of interneurons and potent inhibition of their pyramidal cell targets.”
From A role for synaptic plasticity in the adolescent development of executive function (2013) · cites this paper as [63]
Recent evidence has established that D2 dopamine receptors on interneurons undergo a profound maturational change during adolescence.
“recent evidence has established that D2 dopamine receptors on interneurons undergo a profound maturational change during adolescence.62, 63, 64”
From A role for synaptic plasticity in the adolescent development of executive function (2013) · cites this paper as [63]
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- Authors
- Tseng, K. Y., & O'Donnell, P.
- Affiliations
- Albany Medical College (US)
- Venue
- Synapse
- Publisher
- Wiley
- Published
- 2007-06-29
- Volume
- 61
- Issue
- 10
- Pages
- 843-850
- ISSN
- 0887-4476 (ISSN-L)
- 1098-2396
- PMC
- PMC2190290
- OpenAlex
- W2164868462
- Cited by
- 141
- References
- 48
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 5 · 2020: 2 · 2019: 6 · 2018: 11 · 2017: 8 · 2016: 9 · 2015: 8 · 2014: 9 · 2013: 16 · 2012: 11
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Synapse (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH57683, R56MH057683, R01MH057683)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- dopamine D2 receptor, GABAergic inhibition, excitatory synaptic transmission, prefrontal cortex, pyramidal neurons, quinpirole, eticlopride, dopamine D1 receptor, postnatal development, puberty, fast-spiking interneurons, picrotoxin
- MeSH terms
- Animals, Animals, Newborn, Dose-Response Relationship, Radiation, Drug Interactions, Electric Stimulation, gamma-Aminobutyric Acid, Male, Synaptic Transmission, Picrotoxin, Salicylamides, Prefrontal Cortex, Receptors, Dopamine D2, Pyramidal Cells, Dopamine Agonists, Dopamine Antagonists, GABA Antagonists, Quinpirole, Excitatory Postsynaptic Potentials, Rats, In Vitro Techniques
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