Cited by 141Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorReceptor Mechanisms and Signaling

D 2 dopamine receptors recruit a GABA component for their attenuation of excitatory synaptic transmission in the adult rat prefrontal cortex

Open access
Tseng, Kuei Y., O'Donnell, Patricio·2007·Synapse

Abstract

The dopamine modulation of neuronal excitability in the prefrontal cortex (PFC) changes during critical late periods of postnatal development. In particular, D 2 receptors activate fast‐spiking interneurons after, and not before, adolescence. To test the functional impact of this change, we investigated the effects of dopamine agonists on PFC excitatory synaptic transmission with whole‐cell recordings from deep‐layer pyramidal neurons in brain slices obtained from prepubertal [postnatal day (PD) 28–35] and postpubertal (PD > 51) rats. Electrical stimulation of superficial layers elicited a fast AMPA/kainate excitatory postsynaptic potential (EPSP). In the adult PFC, the D 2 agonist quinpirole decreased EPSP amplitude, an effect that lasted for at least 25 min after drug washout and was blocked by the D 2 antagonist eticlopride. The late component of this effect was blocked by the GABA‐A antagonist picrotoxin without affecting the early inhibition. Quinpirole also decreased EPSP amplitude in deep‐layer pyramidal neurons from prepubertal rats, but this response was not affected by picrotoxin. A D 1 agonist, on the other hand, did not affect the pyramidal neuron EPSP. These results indicate that D 2 , not D 1 , receptors attenuate local excitatory synaptic transmission in the adult PFC, and this effect of D 2 involves a recruitment of local GABAergic activity. Synapse 61:843–850, 2007. © 2007 Wiley‐Liss, Inc.

Integrity signals

Registry

Crossref · 10.1002/syn.20432

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Prior to adolescence, D2 stimulation elicits either no effect or only weak inhibition on interneurons; in adult animals, stimulation of D2 receptors is strongly excitatory and results in robust firing of interneurons and potent inhibition of their pyramidal cell targets.

    “Prior to adolescence, D2 stimulation elicits either no effect or only weak inhibition on interneurons. However, in adult animals stimulation of D2 receptors is strongly excitatory and therefore results in robust firing of interneurons and potent inhibition of their pyramidal cell targets.”
  • Recent evidence has established that D2 dopamine receptors on interneurons undergo a profound maturational change during adolescence.

    “recent evidence has established that D2 dopamine receptors on interneurons undergo a profound maturational change during adolescence.62, 63, 64”

Cites

Flagged first, then by citations

1 of the 48 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Tseng, K. Y., & O'Donnell, P.
Affiliations
Albany Medical College (US)
Venue
Synapse
Publisher
Wiley
Published
2007-06-29
Volume
61
Issue
10
Pages
843-850
ISSN
  • 0887-4476 (ISSN-L)
  • 1098-2396
OpenAlex
W2164868462
Cited by
141
References
48
Citations by year
2026: 2 · 2025: 5 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 5 · 2020: 2 · 2019: 6 · 2018: 11 · 2017: 8 · 2016: 9 · 2015: 8 · 2014: 9 · 2013: 16 · 2012: 11
FWCI
3.97
Type
journal article
Language
en
Open access
Locations
  • Synapse (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (MH57683, R56MH057683, R01MH057683)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords
dopamine D2 receptor, GABAergic inhibition, excitatory synaptic transmission, prefrontal cortex, pyramidal neurons, quinpirole, eticlopride, dopamine D1 receptor, postnatal development, puberty, fast-spiking interneurons, picrotoxin
MeSH terms
Animals, Animals, Newborn, Dose-Response Relationship, Radiation, Drug Interactions, Electric Stimulation, gamma-Aminobutyric Acid, Male, Synaptic Transmission, Picrotoxin, Salicylamides, Prefrontal Cortex, Receptors, Dopamine D2, Pyramidal Cells, Dopamine Agonists, Dopamine Antagonists, GABA Antagonists, Quinpirole, Excitatory Postsynaptic Potentials, Rats, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review