The DOI matches its Crossref record; 55 of the 56 references it cites were found in a registry or an index.
What is lipofuscin? Defining characteristics and differentiation from other autofluorescent lysosomal storage bodies
Abstract
Lipofuscins, also known as age-pigments, have three defining characteristics: (1) they consist of intracellular secondary lysosomes; (2) they have a yellow autofluorescent emission when excited by near ultraviolet or blue light; and (3) they accumulate during normal senescence. Lysosomal storage bodies with similar fluorescence properties accumulate in various cell types as a result of specific pathological conditions or experimental manipulations. As a class, the latter are often referred to as ceroid pigments. In general, the mechanisms involved in the formation of ceroid pigments cannot be assumed to be closely similar to those involved in lipofuscin formation. In fact, the mechanisms of formation almost certainly differ, not only between lipofuscins and ceroids, but also among different lipofuscins and different ceroids. Presently, the most detailed knowledge about the mechanisms involved in lipofuscin formation come from studies on the retinal pigment epithelium (RPE) of the eye. These studies indicate that at least the autofluorescent constituents of RPE lipofuscin are generated from derivatives of vitamin A that occur in the retina. Oxidative stress to the retina appears to promote the formation of these RPE fluorophores. Whether similar mechanisms are involved in the formation of the lipofuscins that occur in other tissues remains to be determined. The mechanisms involved in RPE lipofuscin fluorophore formation are closely related to metabolic pathways that are specif…
Verifying this paper
8 of 9 steps done · this page updates itself — you can leave and come back
- Registry recordVerified
- Full textOnly the abstract is openly available
- Reference list56 references found
- Reference checkChecking each cited work — 55 of 55
- StatisticsNeeds the full text
- ClaimsNeeds the full text
- Cited sourcesNeeds claims to check
- Self-checkNeeds the full text
- VerificationFindings verified
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Taken together, these pieces of evidence have led to the proposal that bis-retinoid precursors of lipofuscin, such as A2PE, form in the photoreceptor OS from all-trans retinal that is escaping reduction to retinol (Katz and Redmond, 2001; Katz and Robinson-Jr, 2002; Sparrow et al., 2010).”
From New insights into retinoid metabolism and cycling within the retina (2013) · cites this paper as Katz and Robinson-Jr, 2002
Citations
Cites
Delori, F. C., Dorey, C. K., Staurenghi, G., Arend, O., Goger, D. G., & Weiter, J. J. (1995) · PubMed · Cited by 938
Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle
Redmond., T. M., Yu, S., Lee, E., Bok, D., Hamasaki, D., Chen, N., Goletz, P., Ma, J.-X., Crouch, R. K., & Pfeifer, K. (1998) · Nature Genetics · doi:10.1038/3813 · Cited by 929
Lipid peroxidation damage to cell components.
Tappel, A. L. (1973) · PubMed · Cited by 902
Weng, J., Mata, N. L., Azarian, S. M., Tzekov, R. T., Birch, D. G., & Travis, G. H. (1999) · Cell · doi:10.1016/s0092-8674(00)80602-9 · Cited by 881
Aging human RPE: morphometric analysis of macular, equatorial, and peripheral cells.
Feeney-Burns, L., Hilderbrand, E. S., & Eldridge, S. (1984) · PubMed · Cited by 561
Chemistry of Visual Adaptation in the Rat
DOWLING, J. E. (1960) · Nature · doi:10.1038/188114a0 · Cited by 543
THE ROLE OF THE PIGMENT EPITHELIUM IN THE ETIOLOGY OF INHERITED RETINAL DYSTROPHY IN THE RAT
Bok, D., & Hall, M. O. (1971) · The Journal of Cell Biology · doi:10.1083/jcb.49.3.664 · Cited by 537
Mullen, R. J., & LaVail, M. M. (1976) · Science · doi:10.1126/science.1265483 · Cited by 529
Chio, K. S., & Tappel, A. L. (1969) · Biochemistry · doi:10.1021/bi00835a019 · Cited by 490
Retinal age pigments generated by self-assembling lysosomotropic detergents
Eldred, G., & Lasky, M. R. (1993) · Nature · doi:10.1038/361724a0 · Cited by 489
Cited by
Sorted by citations
Oxidative Stress in Aging Human Skin
Rinnerthaler, M., Bischof, J., Streubel, M., Trost, A., & Richter, K. (2015) · Biomolecules · doi:10.3390/biom5020545 · Cited by 1,053
Oxidative Stress and Autophagy
Kiffin, R., Bandyopadhyay, U., & Cuervo, A. M. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.152 · Cited by 529
Oxidative Damage Increases and Antioxidant Gene Expression Decreases with Aging in the Mouse Ovary
Lim, J., & Luderer, U. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.110.088583 · Cited by 298
Smoking and Age-Related Macular Degeneration: Review and Update
Velilla, S., García‐Medina, J. J., García‐Layana, A., Dolz‐Marco, R., Pons-Vázquez, S., Pinazo-Duran, M. D., Gómez‐Ulla, F., Arévalo, J. F., Díaz-Llopis, M., & Gallego‐Pinazo, R. (2013) · Journal of Ophthalmology · doi:10.1155/2013/895147 · Cited by 244
Masuda, T., Shimazawa, M., & Hara, H. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/9208489 · Cited by 221
Quantitative Autofluorescence and Cell Density Maps of the Human Retinal Pigment Epithelium
Ach, T., Huisingh, C., McGwin, G., Messinger, J. D., Zhang, T., Bentley, M. J., Gutierrez, D. B., Ablonczy, Z., Smith, R. T., Sloan, K. R., et al. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-14802 · Cited by 220
The comparative biology of neuromelanin and lipofuscin in the human brain
Double, K. L., Dedov, V. N., Fedorow, H., Kettle, E., Halliday, G. M., Garner, B., & Brunk, U. T. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-7581-9 · Cited by 181
Ach, T., Tolstik, E., Messinger, J. D., Zarubina, A. V., Heintzmann, R., & Curcio, C. A. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-16274 · Cited by 177
BERTRAM, K. M., Baglole, C. J., Phipps, R. P., & Libby, R. T. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00126.2009 · Cited by 151
Iron homeostasis and organismal aging
Zeidan, R. S., Han, S. M., Leeuwenburgh, C., & Xiao, R. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101510 · Cited by 155
Pugazhendhi, A., Hubbell, M., Jairam, M. P., & Ambati, B. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031170 · Cited by 148
Lozano-Torres, B., Estepa-Fernández, A., Rovira, M., Orzáez, M., Serrano, M., Martínez-Máñez, R., & Sancenón, F. (2019) · Nature Reviews Chemistry · doi:10.1038/s41570-019-0108-0 · Cited by 140
Reviewing the relevance of fluorescence in biological systems
Lagorio, M. G., Cordon, G. B., & Iriel, A. (2015) · Photochemical & Photobiological Sciences · doi:10.1039/c5pp00122f · Cited by 139
DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes
Sýkora, P., Misiak, M., Wang, Y., Ghosh, S., Leandro, G. D. S., Liu, D., Tian, J. Y., Baptiste, B. A., Cong, W., Brenerman, B. M., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1356 · Cited by 140
Boyer, N. P., Higbee, D., Currin, M. B., Blakeley, L. R., Chen, C., Ablonczy, Z., Crouch, R. K., & Koutalos, Y. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.329235 · Cited by 133
New insights into retinoid metabolism and cycling within the retina
Tang, P. H., Kono, M., Koutalos, Y., Ablonczy, Z., & Crouch, R. K. (2013) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2012.09.002 · Cited by 122
“…removal of all-trans retinal that occurs as a part of the light detection process is thought to be associated with the formation of lipofuscin (Katz and Redmond, 2001; Katz and Robinson, 2002; Sparrow et al., 2010), the fluorescent pigment that accumulates with age in the RPE lysosomal compartment.”
InfluentialMackenzie, C. L., Lynch, S. A., Culloty, S. C., & Malham, S. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099712 · Cited by 121
How good is the evidence that cellular senescence causes skin ageing?
Low, E., Alimohammadiha, G., Smith, L. A., Costello, L., Przyborski, S. A., von Zglinicki, T., & Miwa, S. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101456 · Cited by 116
Aged lipid‐laden microglia display impaired responses to stroke
Arbaizar‐Rovirosa, M., Pedragosa, J., Lozano, J. J., Casal, C., Pol, A., Gallizioli, M., & Planas, A. M. (2023) · EMBO Molecular Medicine · doi:10.15252/emmm.202217175 · Cited by 94
Complement inhibition as a therapeutic strategy in retinal disorders
Kassa, E., Ciulla, T. A., Hussain, R. M., & Dugel, P. U. (2019) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2019.1575358 · Cited by 94
Schmitz-Valckenberg, S., Fleckenstein, M., Helb, H. –., Issa, P. C., Scholl, H. P. N., & Holz, F. G. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2484 · Cited by 85
Sabour‐Pickett, S., Nolan, J. M., Loughman, J., & Beatty, S. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100219 · Cited by 85
Autophagy, Redox Signaling, and Ventricular Remodeling
Gurusamy, N., & Das, D. K. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2524 · Cited by 83
Dolz‐Marco, R., Litts, K. M., Tan, A. C. S., Freund, K. B., & Curcio, C. A. (2017) · Ophthalmology · doi:10.1016/j.ophtha.2017.03.043 · Cited by 78
Rivera‐Ingraham, G. A., Barri, K., Boël, M., Farcy, É., Charles, A., Gény, B., & Lignot, J. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.128595 · Cited by 67
CURRENT KNOWLEDGE AND TRENDS IN AGE-RELATED MACULAR DEGENERATION
Vélez-Montoya, R., Oliver, S. C. N., Olson, J. L., Fine, S. L., Mandava, N., & Quiroz-Mercado, H. (2012) · Retina · doi:10.1097/iae.0b013e318271f265 · Cited by 69
Ocular Disease Therapeutics: Design and Delivery of Drugs for Diseases of the Eye
Cheng, K., Hsieh, C., Nepali, K., & Liou, J. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01033 · Cited by 69
Meleppat, R. K., Ronning, K. E., Karlen, S. J., Burns, M. E., Pugh, E. N., & Zawadzki, R. J. (2021) · Scientific Reports · doi:10.1038/s41598-021-95320-z · Cited by 63
Localisation and significance of in vivo near-infrared autofluorescent signal in retinal imaging
Schmitz-Valckenberg, S., Lara, D., Nizari, S., Normando, E. M., Guo, L., Wegener, A. R., Tufail, A., Fitzke, F. W., Holz, F. G., & Cordeiro, M. F. (2010) · British Journal of Ophthalmology · doi:10.1136/bjo.2010.189498 · Cited by 61
Rôżanowska, M. (2023) · Antioxidants · doi:10.3390/antiox12122111 · Cited by 61
Terao, R., Lee, T. J., Colasanti, J. J., Pfeifer, C. W., Lin, J. B., Santeford, A. C., Hase, K., Yamaguchi, S., Du, D., Sohn, B. S., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114102 · Cited by 62
Cellular Senescence Is Associated With Human Retinal Microaneurysm Formation During Aging
López‐Luppo, M., Catita, J., Ramos, D., Navarro, M., Carretero, A., Mendes-Jorge, L., Muñoz‐Cánoves, P., Rodríguez‐Baeza, A., Nacher, V., & Ruberte, J. (2017) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-20312 · Cited by 58
Stargardt macular dystrophy and evolving therapies
Hussain, R. M., Ciulla, T. A., Berrocal, A. M., Gregori, N. Z., Flynn, H. W., & Lam, B. L. (2018) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2018.1513486 · Cited by 56
Katz, M. L., Rustad, E., Robinson, G. O., Whiting, R. E. H., Student, J. T., Coates, J. R., & Narfström, K. L. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.08.017 · Cited by 51
Self-citationPharmacotherapy of retinal disease with visual cycle modulators
Hussain, R. M., Gregori, N. Z., Ciulla, T. A., & Lam, B. L. (2018) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2018.1448060 · Cited by 52
Bessho, K., Gomi, F., Harino, S., Sawa, M., Sayanagi, K., Tsujikawa, M., & Tano, Y. (2009) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-008-1033-y · Cited by 50
Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype
Soldati, C., López-Fabuel, I., Wanderlingh, L. G., Macia, M. G., Monfregola, J., Esposito, A., Napolitano, G., Guevara‐Ferrer, M., Rosato, A. S., Krogsaeter, E. K., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202013742 · Cited by 46
Differences in the post-stroke innate immune response between young and old
Gallizioli, M., Arbaizar‐Rovirosa, M., Brea, D., & Planas, A. M. (2023) · Seminars in Immunopathology · doi:10.1007/s00281-023-00990-8 · Cited by 45
Multimodal structural disease progression of retinitis pigmentosa according to mode of inheritance
Jauregui, R., Takahashi, V. K. L., Park, K. S., Cui, X., Takiuti, J. T., de Carvalho, J. R. L., & Tsang, S. H. (2019) · Scientific Reports · doi:10.1038/s41598-019-47251-z · Cited by 44
Retinal Photodamage by Endogenous and Xenobiotic Agents†
Wielgus, A. R., & Roberts, J. E. (2012) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2012.01174.x · Cited by 44
LI, G., LIAO, Y., Wang, X., SHENG, S., & Yin, D. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2005.12.008 · Cited by 33
Homa, J., Stalmach, M., Wilczek, G., & Kołaczkowska, E. (2016) · Journal of Comparative Physiology B · doi:10.1007/s00360-016-0973-5 · Cited by 31
Mantes, A. D., Herrera, A., Khven, I. M., Schlaeppi, A., Kyriacou, E., Tsissios, G., Skoufa, E., Santangeli, L., Buglakova, E., Durmuş, E., et al. (2025) · Nature Methods · doi:10.1038/s41592-025-02662-x · Cited by 34
Lu, T., Harper, A. F., Dibner, J. J., Scheffler, J. M., Corl, B. A., Estienne, M. J., Zhao, J., & Dalloul, R. A. (2014) · Journal of Animal Science · doi:10.2527/jas.2013-7112 · Cited by 30
Pharmacologic treatment of atrophic age-related macular degeneration
Mata, N. L., & Vogel, R. (2010) · Current Opinion in Ophthalmology · doi:10.1097/icu.0b013e32833866c8 · Cited by 26
Imaging of cellular aging in human retinal blood vessels
Catita, J., López‐Luppo, M., Ramos, D., Nacher, V., Navarro, M., Carretero, A., Sánchez‐Chardi, A., Mendes-Jorge, L., Rodríguez‐Baeza, A., & Ruberte, J. (2015) · Experimental Eye Research · doi:10.1016/j.exer.2015.03.019 · Cited by 25
Disease asymmetry and hyperautofluorescent ring shape in retinitis pigmentosa patients
Jauregui, R., Chan, L., Oh, J. K., Cho, A., Sparrow, J. R., & Tsang, S. H. (2020) · Scientific Reports · doi:10.1038/s41598-020-60137-9 · Cited by 26
A neuronal aging pattern unique to humans and common chimpanzees
Gilissen, E., Leroy, K., Yilmaz, Z., Kövari, E., Bouras, C., Boom, A., Poncelet, L., ERWIN, J. M., Sherwood, C. C., Hof, P. R., et al. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0931-5 · Cited by 26
Lifespan-extending property of 6-shogaol from Zingiber officinale Roscoe in Caenorhabditis elegans
Lee, E.-B., Kim, J. H., Kim, Y. J., Noh, Y. J., Kim, S. J., Hwang, I. H., & Kim, D. K. (2018) · Archives of Pharmacal Research · doi:10.1007/s12272-018-1052-0 · Cited by 23
Jauregui, R., Park, K. S., Duong, J., Sparrow, J. R., & Tsang, S. H. (2018) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2018.07.012 · Cited by 22
Dougnon, G., & Matsui, H. (2025) · Translational Neurodegeneration · doi:10.1186/s40035-025-00529-x · Cited by 23
Spectral Optical Properties of Rabbit Brain Cortex between 200 and 1000 nm
Gonçalves, T., Martins, I. S., Silva, H., Tuchin, V. V., & Oliveira, L. M. C. (2021) · Photochem · doi:10.3390/photochem1020011 · Cited by 21
The 11-cis Retinal Origins of Lipofuscin in the Retina
Adler, L., Boyer, N. P., Chen, C., Ablonczy, Z., Crouch, R. K., & Koutalos, Y. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.07.022 · Cited by 22
Elevated Fundus Autofluorescence in Monkeys Deficient in Lutein, Zeaxanthin, and Omega-3 Fatty Acids
McGill, T. J., Renner, L. M., & Neuringer, M. D. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-18596 · Cited by 21
Vaschenko, M. A., Zhadan, P. M., Aminin, D. L., & Almyashova, T. N. (2011) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-011-9733-4 · Cited by 19
Quantitative Fundus Autofluorescence in Systemic Chloroquine/Hydroxychloroquine Therapy
Reichel, C., Berlin, A., Radun, V., Ţărău, I., Hillenkamp, J., Kleefeldt, N., Sloan, K., & Ach, T. (2020) · Translational Vision Science & Technology · doi:10.1167/tvst.9.9.42 · Cited by 14
Di, Y., Lu, N., Li, B., Liu, R., Chu, R., Zhou, X., & Zhou, X. (2013) · Current Eye Research · doi:10.3109/02713683.2013.807931 · Cited by 18
RetractedKotnala, A., Senthilkumari, S., Gong, W., Stewart, T. G., Curcio, C. A., Halder, N., Singh, S. B., Kumar, A., & Velpandian, T. (2022) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.63.6.6 · Cited by 17
Katz, M. L., Wendt, K. D., & Sanders, D. N. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.11.004 · Cited by 17
Self-citationHakvoort, K., Otto, L., Haeren, R. H. L., Hoogland, G., Schijns, O. E. M. G., Vink, H., Klein, D. C. G., van Zandvoort, M. A. M. J., & Rijkers, K. (2020) · The Journal of Comparative Neurology · doi:10.1002/cne.24971 · Cited by 16
Characterizing and Quenching Autofluorescence in Fixed Mouse Adrenal Cortex Tissue
Sakr, N., Glazova, O., Shevkova, L., Onyanov, N., Kaziakhmedova, S., Shilova, A., Vorontsova, M. V., & Volchkov, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043432 · Cited by 15
Label-free optical metabolic imaging of adipose tissues for prediabetes diagnosis
Chen, L., Qin, G., Liu, Y., Li, M., Li, Y., Guo, L., Du, L., Zheng, W., Wu, P., Chuang, Y.-H., et al. (2023) · Theranostics · doi:10.7150/thno.82697 · Cited by 17
Boyer, N. P., Thompson, D. A., & Koutalos, Y. (2021) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.62.2.1 · Cited by 15
Lipofuscin and A2E Accumulate with Age in the Retinal Pigment Epithelium of Nrl−/− Mice†
Boyer, N. P., Tang, P. H., Higbee, D., Ablonczy, Z., Crouch, R. K., & Koutalos, Y. (2012) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2012.01127.x · Cited by 14
Zhang, R., Wang, L., Wang, Y.-F., Wu, C., Lei, C.-L., Wang, M., & Ma, L. (2015) · Gene · doi:10.1016/j.gene.2015.04.068 · Cited by 14
Goerdt, L., Clark, M. E., Thomas, T. N., Gao, L., McGwin, G. G., Hammer, M., Crosson, J. N., Sloan, K. R., Owsley, C. J., & Curcio, C. A. (2025) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.66.4.56 · Cited by 13
A2E Distribution in RPE Granules in Human Eyes
Guan, Z., Li, Y., Jiao, S., Yeasmin, N., Rosenfeld, P. J., Dubovy, S. R., Lam, B. L., & Wen, R. (2020) · Molecules · doi:10.3390/molecules25061413 · Cited by 13
Jentoft, I. M. A., & Schuh, M. (2025) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101323-031045 · Cited by 13
Walters, D. K., & Jelinek, D. F. (2019) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155419896802 · Cited by 12
Mitchell, M. E., Cook, L. C., Shiers, S. I., Tavares‐Ferreira, D., Akopian, A. N., Dussor, G. O., & Price, T. J. (2023) · The Journal of Comparative Neurology · doi:10.1002/cne.25463 · Cited by 12
Noguera, P. A., Grunow, B., Klinger, M. H. F., Lester, K., Collet, B., & Del‐Pozo, J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181058 · Cited by 12
Sapio, M. R., King, D. M., Maric, D., Shah, S. S., TALBOT, T. L., Manalo, A. P., Nara, P., Ma, W., Ghetti, A., Ramsden, C. E., et al. (2025) · Journal of Pain · doi:10.1016/j.jpain.2025.105359 · Cited by 10
The effect of various levels of stroboscopic illumination on the growth of guinea pig eyes
Di, Y., Lu, N., Liu, R., Chu, R., Zhou, X., & Zhou, X. (2013) · Clinical and Experimental Optometry · doi:10.1111/cxo.12079 · Cited by 10
Potential reversibility of lipofuscin accumulation
Katz, M. L. (2002) · Archives of Gerontology and Geriatrics · doi:10.1016/s0167-4943(02)00008-0 · Cited by 10
Self-citationAdler, L., Chen, C., & Koutalos, Y. (2017) · Experimental Eye Research · doi:10.1016/j.exer.2017.02.007 · Cited by 10
Visual Transduction and Age-Related Changes in Lipofuscin
RóŻanowski, M., & Różanowski, B. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-374-5_20 · Cited by 11
da Fonseca, D. B., Sheehy, M. R. J., & Shelton, P. M. J. (2003) · Journal of Experimental Marine Biology and Ecology · doi:10.1016/s0022-0981(03)00048-0 · Cited by 10
Crowley, C., Gandy, R. L., Daly, K., & Vleet, E. S. V. (2014) · Aquatic Biology · doi:10.3354/ab00572 · Cited by 9
Occurrence and characterization of lipofuscin and ceroid in human atherosclerotic plaque
Perrotta, I. D. (2018) · Ultrastructural Pathology · doi:10.1080/01913123.2018.1544953 · Cited by 9
Nürnberg, D., Seibel, I., Riechardt, A. I., Brockmann, C., Zeitz, O., Heufelder, J., & Joussen, A. M. (2018) · Klinische Monatsblätter für Augenheilkunde · doi:10.1055/a-0667-0806 · Cited by 7
Individual variability in the structural properties of neurons in the human inferior olive
Baizer, J. S., Wong, K. M., Sherwood, C. C., Hof, P. R., & Witelson, S. F. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1580-2 · Cited by 7
Overview of molecular signatures of senescence and associated resources: pros and cons
Ntintas, O. A., Vagena, S., Pantelis, P., Theocharous, G., Petty, R., Evangelou, K., & Gorgoulis, V. G. (2026) · FEBS Open Bio · doi:10.1002/2211-5463.70134 · Cited by 6
Silybin reduces lipid peroxidation of rat hepatocyte membrane caused by cyclosporin A
Moulisová, V., Srbová, M., Jedlickova, O., Šebestián, J., & Jegorov, A. (2006) · Biochemistry (Moscow) · doi:10.1134/s0006297906100087 · Cited by 6
Growth and recruitment rates of juvenile blue crabs ( Callinectes sapidus) in Chesapeake Bay
Puckett, B. J. (2006) · University Libraries (University of Maryland) · Cited by 6
Kandurova, K., Sumin, D. S., Mamoshin, A. V., & Potapova, E. (2023) · Lasers in Surgery and Medicine · doi:10.1002/lsm.23695 · Cited by 5
Identification of endogenous fluorophores in the photoreceptors using autofluorescence spectroscopy
Zhao, L., Qu, J., & Niu, H. (2007) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.760139 · Cited by 5
Ach, T., & Bermond, K. (2017) · Klinische Monatsblätter für Augenheilkunde · doi:10.1055/s-0043-109891 · Cited by 5
Renteria, C. A., Park, J., Zhang, C., Sorrells, J. E., Iyer, R. R., Tehrani, K. F., la Cadena, A. D., & Boppart, S. A. (2024) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2024.110171 · Cited by 4
Gonadal Rejuvenation of Mice by Growth Differentiation Factor 11
Zhou, Y., Ni, S., Li, C., Song, L., & Zhang, S. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab343 · Cited by 4
Then, A., Welly, R. J., Bullock, G., Chevallier, L., & Katz, M. L. (2025) · Genes · doi:10.3390/genes16111370 · Cited by 3
Self-citationQualls, K. A., Kadakia, F. K., Serafin, E. K., Lückemeyer, D. D., Davidson, S., Strong, J. A., & Zhang, J. (2025) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000007133 · Cited by 3
Kinetics of Rhodopsin’s Chromophore Monitored in a Single Photoreceptor
Adler, L., Boyer, N. P., Chen, C., & Koutalos, Y. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2330-4_21 · Cited by 3
Hybridization Chain Reaction for mRNA Localization in Single Cells from Mouse and Human Cryosections
May-Zhang, A. A., Benthal, J. T., & Southard‐Smith, E. M. (2022) · Current Protocols · doi:10.1002/cpz1.439 · Cited by 3
Navaratnam, J., Bærland, T. P., Eide, N. A., Faber, R. T., Rekstad, B. L., Vavvas, D. G., & Bragadóttir, R. (2019) · Ocular Oncology and Pathology · doi:10.1159/000499403 · Cited by 3
Cozzi, M., Viola, F., Belotti, M., Cigada, M., Cherepanoff, S., Staurenghi, G., & Invernizzi, A. (2020) · Ophthalmology Retina · doi:10.1016/j.oret.2020.07.029 · Cited by 3
Multispectral autofluorescence lifetime imaging of RPE cells using two-photon excitation
Zhao, L., Chen, D., Qi, J., & Qu, J. (2010) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.845952 · Cited by 2
Hammer, M., Oertel, J., Alderzy, H., Tarhan, M., Meller, D., & Curcio, C. A. (2025) · Experimental Eye Research · doi:10.1016/j.exer.2025.110500 · Cited by 2
Antioxidants in the retina and vitreous — current state of knowledge
Pietras-Baczewska, A., Nowomiejska, K., Sztanke, M., Toro, M. D., & Ręjdak, R. (2020) · Ophthalmology Journal · doi:10.5603/oj.2020.0018 · Cited by 2
Model Nematodes in Obesity Research
Nie, Y., & Stürzenbaum, S. R. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809468-6.00011-5 · Cited by 2
Kotnala, A., Senthilkumari, S., Halder, N., Kumar, A., & Velpandian, T. (2017) · Journal of Chromatography B · doi:10.1016/j.jchromb.2017.11.021 · Cited by 2
Metadata
- Authors
- Katz, M. L., & Robison, W. G.
- Affiliations
- University of Missouri (US)
- National Institutes of Health (US)
- Corresponding author
- Katz, Martin L
- Robison, W.Gerald
- ORCID
- Katz, Martin L
- Venue
- Archives of Gerontology and Geriatrics
- Publisher
- Elsevier BV
- Published
- 2002-05
- Volume
- 34
- Issue
- 3
- Pages
- 169-184
- ISSN
- 0167-4943 (ISSN-L)
- OpenAlex
- W1980724564
- Cited by
- 122
- References
- 56
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 3 · 2023: 6 · 2022: 5 · 2021: 9 · 2020: 9 · 2019: 6 · 2018: 7 · 2017: 11 · 2016: 2 · 2015: 9 · 2014: 7 · 2013: 3 · 2012: 8
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Gerontology and Geriatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Genetics (clinical) › Lysosomal Storage Disorders Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- lipofuscin, ceroid pigment, autofluorescence, secondary lysosomes, cellular senescence, retinal pigment epithelium, vitamin A derivatives, oxidative stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
