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Cited by 123Autophagy in Disease and TherapyLysosomal Storage Disorders ResearchGenetics, Aging, and Longevity in Model Organisms

The DOI matches its Crossref record; 55 of the 56 references it cites were found in a registry or an index.

What is lipofuscin? Defining characteristics and differentiation from other autofluorescent lysosomal storage bodies

Katz, Martin L, Robison, W.Gerald·2002·Archives of Gerontology and Geriatrics
DOI 10.1016/s0167-4943(02)00005-5
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Abstract

Lipofuscins, also known as age-pigments, have three defining characteristics: (1) they consist of intracellular secondary lysosomes; (2) they have a yellow autofluorescent emission when excited by near ultraviolet or blue light; and (3) they accumulate during normal senescence. Lysosomal storage bodies with similar fluorescence properties accumulate in various cell types as a result of specific pathological conditions or experimental manipulations. As a class, the latter are often referred to as ceroid pigments. In general, the mechanisms involved in the formation of ceroid pigments cannot be assumed to be closely similar to those involved in lipofuscin formation. In fact, the mechanisms of formation almost certainly differ, not only between lipofuscins and ceroids, but also among different lipofuscins and different ceroids. Presently, the most detailed knowledge about the mechanisms involved in lipofuscin formation come from studies on the retinal pigment epithelium (RPE) of the eye. These studies indicate that at least the autofluorescent constituents of RPE lipofuscin are generated from derivatives of vitamin A that occur in the retina. Oxidative stress to the retina appears to promote the formation of these RPE fluorophores. Whether similar mechanisms are involved in the formation of the lipofuscins that occur in other tissues remains to be determined. The mechanisms involved in RPE lipofuscin fluorophore formation are closely related to metabolic pathways that are specif…

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Metadata

Authors
Katz, M. L., & Robison, W. G.
Affiliations
  • University of Missouri (US)
  • National Institutes of Health (US)
Corresponding author
  • Katz, Martin L
  • Robison, W.Gerald
ORCID
Katz, Martin L
Venue
Archives of Gerontology and Geriatrics
Publisher
Elsevier BV
Published
2002-05
Volume
34
Issue
3
Pages
169-184
ISSN
0167-4943 (ISSN-L)
DOI
10.1016/s0167-4943(02)00005-5
OpenAlex
W1980724564
Cited by
122
References
56
Citations by year
2026: 4 · 2025: 10 · 2024: 3 · 2023: 6 · 2022: 5 · 2021: 9 · 2020: 9 · 2019: 6 · 2018: 7 · 2017: 11 · 2016: 2 · 2015: 9 · 2014: 7 · 2013: 3 · 2012: 8
FWCI
0.76
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Archives of Gerontology and Geriatrics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
  • Health Sciences › Medicine › Genetics (clinical) › Lysosomal Storage Disorders Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
lipofuscin, ceroid pigment, autofluorescence, secondary lysosomes, cellular senescence, retinal pigment epithelium, vitamin A derivatives, oxidative stress

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