The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Hormonal profile in patients with congestive heart failure
Abstract
Background Recent progress has been made in the understanding of the cellular and molecular mechanisms of growth hormone action and of its effects on cardiac tissue. The aim of this study was to measure growth hormone concentrations, along with various other hormones, in patients with stable chronic congestive heart failure due to idiopathic dilated cardiomyopathy.Methods The study included 23 ambulatory men, 51.2+/-9.3 years of age, on standard medical therapy for heart failure due to idiopathic dilated cardiomyopathy. All patients underwent clinical and laboratory evaluations, including echocardiogram, radionuclide ventriculography, right heart catheterization, coronary angiography, and right ventricular endomyocardial biopsy. Serum or plasma concentrations of growth, thyroid, sex and adrenal hormones were measured in all patients and compared with those found in 20 age-matched healthy men.Results Growth hormone, insulin-like growth factor I, and free testosterone values in patients with idiopathic dilated cardiomyopathy and heart failure were 0.37+/-0.2 ng/ml, 123.7+/-50 ng/ml and 48.6+/-23.8 pmol/l, respectively, versus 0.5+/-0.4 ng/ml (P<0.01), 236.3+/-66.4 ng/ml (P<0.001) and 105+/-17 pmol/l (P<0.01), respectively, in the healthy age-matched individuals. All other hormone concentrations were comparable in both groups.Conclusions Chronic heart failure due to idiopathic dilated cardiomyopathy is associated with a significant decrease in growth hormone, insulin-like growth factor I, and testosterone concentrations, probably due to chronic disease.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Anabolic hormones such as testosterone are under expressed in heart failure [3,4]”
From The Effect of Testosterone on Insulin Sensitivity in Men with Heart Failure (2007) · cites this paper as [3]
In the citing paper
“a cross-sectional study of patients with heart failure found that 43% of patients had manifest disorders of glucose metabolism ranging from frank diabetes to impaired glucose sensitivity [3].”
From The Effect of Testosterone on Insulin Sensitivity in Men with Heart Failure (2007) · cites this paper as [3]
Citations
Cites
Effects of Enalapril on Mortality in Severe Congestive Heart Failure
The Consensus Trial Study Group* (1987) · New England Journal of Medicine · doi:10.1056/nejm198706043162301 · Cited by 5,109
Swedberg, K. B., & KJEKSHUS, J. K. (1988) · The American Journal of Cardiology · doi:10.1016/s0002-9149(88)80087-0 · Cited by 3,762
Packer, M. (1992) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(92)90167-l · Cited by 1,060
Saccà, L., Cittadini, A., & Fazio, S. (1994) · Endocrine Reviews · doi:10.1210/edrv-15-5-555 · Cited by 538
Bengtsson, B., Edén, S., Ernest, I., Odén, A., & Sjögren, B. (1988) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1988.tb15881.x · Cited by 527
A Preliminary Study of Growth Hormone in the Treatment of Dilated Cardiomyopathy
Fazio, S., Sabatini, D., Capaldo, B., Vigorito, C., Giordano, A., Guida, R., Pardo, F., Biondi, B., & Saccà, L. (1996) · New England Journal of Medicine · doi:10.1056/nejm199603283341301 · Cited by 498
Pathophysiology of chronic heart failure
Packer, M. (1992) · The Lancet · doi:10.1016/0140-6736(92)90405-r · Cited by 474
Regulation of rat growth hormone receptor gene expression
Mathews, L. S., Enberg, B., & Norstedt, G. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81745-8 · Cited by 448
Amato, G., Carella, C., Fazio, S., MONTAGNA, G. L., Cittadini, A., Sabatini, D., Marciano-Mone, C., Saccà, L., & Bellastella, A. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.6.8263158 · Cited by 439
Ito, H., Hiroe, M., Hirata, Y., Tsujino, M., Adachi, S., Shichiri, M., Koike, A., Nogami, A., & Marumo, F. (1993) · Circulation · doi:10.1161/01.cir.87.5.1715 · Cited by 405
Cited by
Sorted by citations
Items 101–145 of 145
Lima, A. R. R., Pagan, L. U., Damatto, R. L., Cezar, M. D. M., Bonomo, C., Gomes, M. J., Martinez, P. F., Guizoni, D. M., de Campos, D. H. S., Damatto, F. C., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.20583 · Cited by 4
Zacharski, M., Tomaszek, A., Kiczak, L., Ugorski, M., Bania, J., Pasławska, U., Rybińska, I., Jankowska, E. A., Janiszewski, A., & Ponikowski, P. P. (2021) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2020.12.024 · Cited by 4
Hodson, B., Woodiwiss, A. J., Norton, G. R., & Michel, F. S. (2014) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000081 · Cited by 4
Therapeutic patents for chronic heart failure: a review of patent applications from 1996 to 2002
Anker, S. D., Jankowska, E. A., & Okonko, D. O. (2004) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.14.5.639 · Cited by 4
Reposição hormonal e exercício físico no tratamento da insuficiência cardíaca: revisão sistemática
de Carvalho, T., de Mara, L. S., & Ulbrich, A. Z. (2011) · Revista Brasileira de Medicina do Esporte · doi:10.1590/s1517-86922011000600013 · Cited by 3
Liu, T., Li, F., Fei, Y., Sun, F., Chen, M., Tian, X., Zheng, W., Zhu, Z., & Wang, W. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1415238 · Cited by 3
Association between Androgenic Hormone Levels and Left Ventricular Ejection Fraction.
Davoodi, G., Amirzadegan, A., Boroumand, M. A., Dehkordi, M. R., Saeid, A. K., Sharif, A. Y., Rezvanfard, M., & Anvari, M. S. (2010) · Europe PMC (PubMed Central) · Cited by 3
Effect of Testosterone Level on Mortality in Patients With Left Ventricular Assist Device
Şimşek, E., Kılıç, S., Kemal, H. S., Nalbantgil, S., Öztürk, P., Yıldırım, I., Yağdı, T., Engin, Ç., & Özbaran, M. (2019) · Transplantation Proceedings · doi:10.1016/j.transproceed.2019.07.028 · Cited by 3
Aging and the Cardiovascular System
Marı́n-Garcı́a, J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-404599-6.00021-4 · Cited by 3
Hormonal Therapy in the Treatment of Chronic Heart Failure
Napoli, R., Salzano, A., Bossone, E., & Cittadini, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809657-4.64122-4 · Cited by 3
Beijerink, N., Lee, W., Stokhof, A. A., Voorhout, G., Mol, J. A., & Kooistra, H. S. (2011) · American Journal of Veterinary Research · doi:10.2460/ajvr.72.1.59 · Cited by 2
Effects of testosterone on norepinephrine release in isolated rat heart
Wang, X., Zhang, Y., Bu, J., Shen, L., & He, B. (2012) · Journal of Huazhong University of Science and Technology [Medical Sciences] · doi:10.1007/s11596-012-0007-9 · Cited by 2
Androgens and cardiac diseases
Bianchi, V. E., & Mezzani, A. (2013) · Monaldi Archives for Chest Disease · doi:10.4081/monaldi.2013.5232 · Cited by 2
Growth hormone in heart failure revisited: An old story retold
Cittadini, A., & D’Assante, R. (2018) · Monaldi Archives for Chest Disease · doi:10.4081/monaldi.2018.989 · Cited by 2
Insuficiencia cardíaca y tiroides. Daño miocárdico en el hipotiroidismo
Perel, C., & Echin, M. (2006) · Redalyc (Universidad Autónoma del Estado de México) · Cited by 2
Nutrition et insuffisance cardiaque
Andréelli, F., Lambare, B., & Lecerf, J. (2021) · Médecine des Maladies Métaboliques · doi:10.1016/j.mmm.2021.02.012 · Cited by 2
Владимировна, Д. А., Grineva, E. N., Sitnikova, M. U., & Shlyakhto, E. V. (2010) · Arterial’naya Gipertenziya (Arterial Hypertension) · doi:10.18705/1607-419x-2010-16-3-299-304 · Cited by 2
Testosterone: a promising adjuvant for a failing heart?
Wickramatilake, C. M., Mohideen, M., & Pathirana, C. (2012) · Journal of the Ceylon College of Physicians · doi:10.4038/jccp.v42i1-2.4551 · Cited by 1
Li, Y., Yue, W.-W., Wu, X., Lü, Y., Yu, J., & Zhang, Y. (2013) · Cited by 1
Işık, S., Çetın, M., Çiçekçioğlu, H., Uçar, Ö., Çetin, Z. G., & Özuğuz, U. (2011) · The Anatolian Journal of Cardiology · doi:10.5152/akd.2011.137 · Cited by 1
OBSOLETE: Hormonal Therapy for Heart Failure
Cittadini, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64122-3 · Cited by 1
Anabolic Deficiencies in Heart Failure
Napoli, R., D’Assante, R., Miniero, M., Salzano, A., & Cittadini, A. (2022) · Cardiology Clinics · doi:10.1016/j.ccl.2021.12.003 · Cited by 1
Testosterone and cardiovascular disease: the conflicting relationship
Das, S. (2008) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2008.01889.x · Cited by 1
Hormones and the heart: Does the cardiovascular system need growth hormone in adult life?
Twickler, T. B., Cramer, M. J., Senden, P. J., de Vries, W. R., & Koppeschaar, H. P. F. (2003) · PubMed Central
Effects of Hormonal Therapy in Patients with Heart Failure
Caminiti, G., FOSSATI, C., Battaglia, D., & Volterrani, M. (2014) · Journal of Cardiology and Therapy
Xue, Y., & Wang, L. (2008) · Bioscience hypotheses · doi:10.1016/j.bihy.2008.05.007
The Role of Hypogonadism in the Evolution of Bone Loss before and after Cardiac Transplantation
Stempfle, H. U. (2005) · Elsevier eBooks · doi:10.1016/b978-012183502-6/50011-0
Exercício intenso e suplementação de testosterona em portadores de insuficiência cardíaca
de Mara, L. S., Filho, J. M. V., Ribeiro, E. P., Ulbrich, A. Z., Lineburger, A. A., Angarten, V. G., Sties, S. W., Pacheco, J. A., & de Carvalho, T. (2014) · Revista Brasileira de Medicina do Esporte · doi:10.1590/1517-86922014200201600
Functional implications of polymorphisms of endothelial nitric oxide synthase gene: Reply
Koch, W. (2004) · European Heart Journal · doi:10.1016/j.ehj.2003.12.001
A complication in male patients awaiting heart transplantation: Osteoporosis
Karapolat, H., Eyigör, S., Zoghi, M., Kirazlı, Y., Nalbantgil, S., Durmaz, B., & Özbaran, M. (2008) · International Journal of Cardiology · doi:10.1016/j.ijcard.2008.11.091
Metabolic Perturbation in Chronic Heart Failure: Time to Redress the balance?
Pugh, P. J. (2007) · Future Cardiology · doi:10.2217/14796678.3.2.131
Marı́n-Garcı́a, J., Goldenthal, M. J., & Moe, G. W. P. L. (2007) · Springer eBooks · doi:10.1007/978-0-387-74072-0_16
Hormones and the heart — is sleep apnoea the link?
Morton, A. (2004) · European Heart Journal · doi:10.1016/j.ehj.2003.07.012
Bianchi, V. E., & Mezzani, A. (2013)
in Children Recombinant Human Growth Hormone Treatment for Dilated Cardiomyopathy
Newburger, J. W., Majzoub, J. A., Crawford, E. C., Bartlett, J. M., McGrath, E. A., McElhinney, D. B., Colan, S. D., Moran, A. M., Wypij, D., & Lin, M. V. (2004)
Haren, M. T. (2005) · Adelaide Research & Scholarship (AR&S) (University of Adelaide)
Study of the relation between serum testosterone level and carotid atherosclerosis in elderly men
Gayar, N. H. E., Mahmoud, M., & Elabd, A. (2015) · Egyptian Journal of Obesity Diabetes and Endocrinology · doi:10.4103/2356-8062.178324
Ayaz, M. (2019) · DalSpace (Dalhousie University)
Sex Steroids, Cognate Receptors, and Aging
Bagchi, G., Dash, A. K., Kumar, S., Jiang, S., Ahn, S., Chatterjee, B., & Tyagi, R. K. (2019) · Springer eBooks · doi:10.1007/978-981-13-3585-3_13
Mechanism of physical intolerance in patients with chronic heart failure
Obrezan, A. G., Perutskiy, D. N., & Александрович, З. А. (2017) · Vestnik of Saint Petersburg University Medicine · doi:10.21638/11701/spbu11.2017.402
da Fonseca, G. W. P. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2020.tde-17062021-134818
Bronisz, A., Myśliwiec, B. J., Hagner–Derengowska, M., de Caro, J. X., & Bronisz, M. (2023) · Archives of Medical Science · doi:10.5114/aoms/158848
The role of testosterone in cardiovascular health: benefits and risks of replacement therapy
Gawełczyk, W., Tokarz, E., Soczyńska, J., Żołyniak, M., Pluta, K., Muzyka, A., & Obrycka, P. (2025) · Medical Journal of Cell Biology · doi:10.2478/acb-2025-0004
Chang, C., & Zhang, J. (2026) · Journal of Cardiothoracic Surgery · doi:10.1186/s13019-025-03802-2
Moreira, V. O. (2006) · Aleph UCLA Undergraduate Research Journal for the Humanities and Social Sciences
Metadata
- Authors
- Kontoleon, P. E., Anastasiou-Nana, M. I., Papapetrou, P. D., Alexopoulos, G., Ktenas, V., Rapti, A. C., Tsagalou, E. P., & Nanas, J. N.
- Affiliations
- Alexandra Hospital (GR)
- National and Kapodistrian University of Athens (GR)
- Venue
- International Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 87
- Issue
- 2-3
- Pages
- 179-183
- ISSN
- 0167-5273 (ISSN-L)
- OpenAlex
- W2066253688
- Cited by
- 145
- References
- 42
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 7 · 2021: 6 · 2020: 5 · 2019: 7 · 2018: 4 · 2017: 8 · 2016: 4 · 2015: 5 · 2014: 10 · 2013: 9 · 2012: 7
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Keywords
- congestive heart failure, idiopathic dilated cardiomyopathy, growth hormone, insulin-like growth factor I, free testosterone, hormonal profile, chronic disease, sex hormones, thyroid hormones, adrenal hormones
- MeSH terms
- Adult, Aged, Analysis of Variance, Cardiomyopathy, Dilated, Heart Failure, Humans, Insulin-Like Growth Factor I, Male, Middle Aged, Probability, Prognosis, Radioimmunoassay, Reference Values, Sensitivity and Specificity, Severity of Illness Index, Growth Hormone, Testosterone, Cohort Studies, Biomarkers, Case-Control Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
