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Cited by 145Growth Hormone and Insulin-like Growth FactorsHormonal and reproductive studiesHeart Failure Treatment and Management

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Hormonal profile in patients with congestive heart failure

Kontoleon, Panagiotis E, Anastasiou-Nana, Maria I, Papapetrou, Petros D, Alexopoulos, George, Ktenas, Vasiliki, Rapti, Ageliki C, Tsagalou, Eleftheria P, Nanas, John N·2003·International Journal of Cardiology
DOI 10.1016/s0167-5273(02)00212-7
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Abstract

Background Recent progress has been made in the understanding of the cellular and molecular mechanisms of growth hormone action and of its effects on cardiac tissue. The aim of this study was to measure growth hormone concentrations, along with various other hormones, in patients with stable chronic congestive heart failure due to idiopathic dilated cardiomyopathy.Methods The study included 23 ambulatory men, 51.2+/-9.3 years of age, on standard medical therapy for heart failure due to idiopathic dilated cardiomyopathy. All patients underwent clinical and laboratory evaluations, including echocardiogram, radionuclide ventriculography, right heart catheterization, coronary angiography, and right ventricular endomyocardial biopsy. Serum or plasma concentrations of growth, thyroid, sex and adrenal hormones were measured in all patients and compared with those found in 20 age-matched healthy men.Results Growth hormone, insulin-like growth factor I, and free testosterone values in patients with idiopathic dilated cardiomyopathy and heart failure were 0.37+/-0.2 ng/ml, 123.7+/-50 ng/ml and 48.6+/-23.8 pmol/l, respectively, versus 0.5+/-0.4 ng/ml (P<0.01), 236.3+/-66.4 ng/ml (P<0.001) and 105+/-17 pmol/l (P<0.01), respectively, in the healthy age-matched individuals. All other hormone concentrations were comparable in both groups.Conclusions Chronic heart failure due to idiopathic dilated cardiomyopathy is associated with a significant decrease in growth hormone, insulin-like growth factor I, and testosterone concentrations, probably due to chronic disease.

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Crossref · 10.1016/s0167-5273(02)00212-7

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Metadata

Authors
Kontoleon, P. E., Anastasiou-Nana, M. I., Papapetrou, P. D., Alexopoulos, G., Ktenas, V., Rapti, A. C., Tsagalou, E. P., & Nanas, J. N.
Affiliations
  • Alexandra Hospital (GR)
  • National and Kapodistrian University of Athens (GR)
Venue
International Journal of Cardiology
Publisher
Elsevier BV
Published
2003-02
Volume
87
Issue
2-3
Pages
179-183
ISSN
0167-5273 (ISSN-L)
DOI
10.1016/s0167-5273(02)00212-7
OpenAlex
W2066253688
Cited by
145
References
42
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 7 · 2021: 6 · 2020: 5 · 2019: 7 · 2018: 4 · 2017: 8 · 2016: 4 · 2015: 5 · 2014: 10 · 2013: 9 · 2012: 7
FWCI
4.68
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • International Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Keywords
congestive heart failure, idiopathic dilated cardiomyopathy, growth hormone, insulin-like growth factor I, free testosterone, hormonal profile, chronic disease, sex hormones, thyroid hormones, adrenal hormones
MeSH terms
Adult, Aged, Analysis of Variance, Cardiomyopathy, Dilated, Heart Failure, Humans, Insulin-Like Growth Factor I, Male, Middle Aged, Probability, Prognosis, Radioimmunoassay, Reference Values, Sensitivity and Specificity, Severity of Illness Index, Growth Hormone, Testosterone, Cohort Studies, Biomarkers, Case-Control Studies

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