CoChat
Sign Up
Cited by 413Hormonal and reproductive studiesHeart Failure Treatment and ManagementAdrenal Hormones and Disorders

Testosterone therapy in men with moderate severity heart failure: a double-blind randomized placebo controlled trial

Malkin, Chris J., Pugh, Peter J., West, John N., van Beek, Edwin J.R., Jones, T. Hugh, Channer, Kevin S.·2006·European Heart Journal
DOI 10.1093/eurheartj/ehi443
Open this paper in CoChat — free account

Abstract

AIMS: Chronic heart failure is associated with maladaptive and prolonged neurohormonal and pro-inflammatory cytokine activation causing a metabolic shift favouring catabolism, vasodilator incapacity, and loss of skeletal muscle bulk and function. In men, androgens are important determinants of anabolic function and physical strength and also possess anti-inflammatory and vasodilatory properties. METHODS AND RESULTS: We conducted a randomized, double-blind, placebo-controlled parallel trial of testosterone replacement therapy (5 mg Androderm) at physiological doses in 76 men (mean+/-SD, age 64+/-9.9) with heart failure (ejection fraction 32.5+/-11%) over a maximum follow-up period of 12 months. The primary endpoint was functional capacity as assessed by the incremental shuttle walk test (ISWT). At baseline, 18 (24%) had serum testosterone below the normal range and bioavailable testosterone correlated with distance walked on the initial ISWT (r=0.3, P=0.01). Exercise capacity significantly improved with testosterone therapy compared with placebo over the full study period (mean change +25+/-15 m) corresponding to a 15+/-11% improvement from baseline (P=0.006 ANOVA). Symptoms improved by at least one functional class on testosterone in 13 (35%) vs. 3 (8%) on placebo (P=0.01). No significant changes were found in handgrip strength, skeletal muscle bulk by cross-sectional computed tomography, or in tumour necrosis factor levels. Testosterone therapy was safe with no excess of adverse events although the patch preparation was not well tolerated by the study patients. CONCLUSION: Testosterone replacement therapy improves functional capacity and symptoms in men with moderately severe heart failure.

Integrity signals

Registry

Crossref · 10.1093/eurheartj/ehi443

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Testosterone improves cardiac ischemia in men with chronic stable angina and symptoms in men with heart failure.

    “These findings and the fact that testosterone improves cardiac ischemia in men with chronic sta-ble angina (43) and symptoms in men with heart failure (44) suggest that the diagnosis of hypogonadism in men with type 2 diabetes has important clinical consequences besides the benefits on libido and well-being associated with normalization of testosterone status.”

    From Clinical and Biochemical Assessment of Hypogonadism in Men With Type 2 Diabetes (2007) · cites this paper as [44]

  • There is some evidence that testosterone replacement is beneficial and improves functional status in men with chronic heart failure.

    “there is some evidence that testosterone replacement is beneficial and improves functional status in men with CHF [5,6].”

    From The Effect of Testosterone on Insulin Sensitivity in Men with Heart Failure (2007) · cites this paper as [6]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Malkin, C. J., Pugh, P. J., West, J. N., van Beek, E. J. R., Jones, T. H., & Channer, K. S.
Affiliations
Royal Hallamshire Hospital (GB)
Corresponding author
Malkin, Chris J.
ORCID
Pugh, Peter J.
Venue
European Heart Journal
Publisher
Oxford University Press (OUP)
Published
2005-08-10
Volume
27
Issue
1
Pages
57-64
ISSN
  • 0195-668X (ISSN-L)
  • 1522-9645
DOI
10.1093/eurheartj/ehi443
OpenAlex
W2130508828
Cited by
413
References
40
Citations by year
2026: 6 · 2025: 10 · 2024: 9 · 2023: 11 · 2022: 16 · 2021: 11 · 2020: 17 · 2019: 24 · 2018: 18 · 2017: 20 · 2016: 22 · 2015: 25 · 2014: 28 · 2013: 29 · 2012: 19
FWCI
11.59
Type
journal article
Language
en
Open access
closed
Locations
  • European Heart Journal (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Funders
Fonds National de la Recherche Luxembourg
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
testosterone replacement therapy, chronic heart failure, men, exercise capacity, functional capacity, incremental shuttle walk test, androgens, bioavailable testosterone, grip strength, skeletal muscle, TNF-α, symptom improvement
MeSH terms
Adult, Aged, Androgens, Chronic Disease, Double-Blind Method, Heart Failure, Hemodynamics, Humans, Male, Middle Aged, Testosterone, Cohort Studies, Treatment Outcome, Hormone Replacement Therapy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review