The Fas counterattack: Cancer as a site of immune privilege

Apoptosis by Death Factor

Nagata, S. (1997) · Cell · doi:10.1016/s0092-8674(00)81874-7 · Cited by 4,908 · see citing works

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

Muzio, M., Chinnaiyan, A. M., Kischkel, F. C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J. D., Zhang, M., Gentz, R., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81266-0 · Cited by 3,046 · see citing works

Inhibition of death receptor signals by cellular FLIP

Irmler, M., Thome, M., Hahne, M., Schneider, P., Hofmann, K., Steiner, V., Bodmer, J.-L., Schröter, M., Burns, K., Mattmann, C., et al. (1997) · Nature · doi:10.1038/40657 · Cited by 2,548 · see citing works

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

Chinnaiyan, A. M., O'Rourke, K., Tewari, M., & Dixit, V. M. (1995) · Cell · doi:10.1016/0092-8674(95)90071-3 · Cited by 2,431 · see citing works

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

Griffith, T. S., Brunner, T., Fletcher, S. M., Green, D. R., & Ferguson, T. A. (1995) · Science · doi:10.1126/science.270.5239.1189 · Cited by 1,990 · see citing works

The proto-oncogene Bcl-2 and its role in regulating apoptosis

Kroemer, G. (1997) · Nature Medicine · doi:10.1038/nm0697-614 · Cited by 1,739 · see citing works

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

Ju, S., Panka, D., Cui, H., Ettinger, R., EI-Khatib, M., Sherr, D., Stanger, B., & Marshak-Rothstein, A. (1995) · Nature · doi:10.1038/373444a0 · Cited by 1,709 · see citing works

Protease activation during apoptosis: Death by a thousand cuts?

Martin, S. J., & Green, D. R. (1995) · Cell · doi:10.1016/0092-8674(95)90422-0 · Cited by 1,334 · see citing works

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

Hahne, M., Rimoldi, D., Schröter, M., Romero, P. J., Schreier, M. H., French, L. E., Schneider, P., Bornand, T., Fontana, A., Liénard, D., et al. (1996) · Science · doi:10.1126/science.274.5291.1363 · Cited by 1,236 · see citing works

Tumor Antigens Recognized by T Lymphocytes

Boon, T., Cerottini, J. C., den Eynde, B. J. V., van der Bruggen, P., & Pel, A. V. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.002005 · Cited by 1,228 · see citing works

FLICE is activated by association with the CD95 death‐inducing signaling complex (DISC)

Medema, J. P., Scaffidi, C., Kischkel, F. C., Shevchenko, A., Mann, M., Krammer, P. H., & Peter, M. E. (1997) · The EMBO Journal · doi:10.1093/emboj/16.10.2794 · Cited by 1,189 · see citing works

A role for CD95 ligand in preventing graft rejection

Bellgrau, D., Gold, D. P., Selawry, H. P., Moore, J. K., Franzusoff, A., & Duke, R. C. (1995) · Nature · doi:10.1038/377630a0 · Cited by 1,147 · see citing works

Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells

Friesen, C., Herr, I., Krammer, P. H., & Debatin, K. (1996) · Nature Medicine · doi:10.1038/nm0596-574 · Cited by 975 · see citing works

Lymphocyte apoptosis induced by CD95 (APO–1/Fas) ligand–expressing tumor cells — A mechanism of immune evasion?

Strand, S., Hofmann, W. J., Hug, H., Müller, M., Otto, G., Strand, D. J., Mariani, S. M., Stremmel, W., Krammer, P. H., & Galle, P. R. (1996) · Nature Medicine · doi:10.1038/nm1296-1361 · Cited by 897 · see citing works

The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand.

O’Connell, J., O’Sullivan, G. C., Collins, J. K., & Shanahan, F. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.3.1075 · Cited by 873 · see citing works

Metalloproteinase-mediated release of human Fas ligand.

Kayagaki, N., Kawasaki, A., Ebata, T., Ohmoto, H., Ikeda, S., Inoue, S., Yoshino, K., Okumura, K., & Yagita∥, H. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.6.1777 · Cited by 816 · see citing works

FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis

Chinnaiyan, A. M., Tepper, C. G., Seldin, M. F., O’Rourke, K. M., Kischkel, F. C., Hellbardt, S., Krammer, P. H., Peter, M. E., & Dixit, V. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.9.4961 · Cited by 767 · see citing works

Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53.

Müller, M., Strand, S., Hug, H., Heinemann, E. M., Walczak, H., Hofmann, W. J., Stremmel, W., Krammer, P. H., & Galle, P. R. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119174 · Cited by 743 · see citing works

Wild-Type Human p53 and a Temperature-Sensitive Mutant Induce Fas/APO-1 Expression

Owen‐Schaub, L. B., Zhang, W. K., Cusack, J. C., Angelo, L. S., Santee, S. M., Fujiwara, T., Roth, J. A., Deisseroth, A., Zhang, W., Kruzel, E., et al. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3032 · Cited by 731 · see citing works

Oral tolerance: immune mechanisms and treatment of autoimmune diseases

Weiner, H. L. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)01053-0 · Cited by 720 · see citing works

FAP-1: A Protein Tyrosine Phosphatase That Associates with Fas

Sato, T., Irie, S., Kitada, S., & Reed, J. C. (1995) · Science · doi:10.1126/science.7536343 · Cited by 683 · see citing works

Downregulation of Fas ligand by shedding

Tanaka, M., Itai, T., Adachi, M., & Nagata, S. (1998) · Nature Medicine · doi:10.1038/nm0198-031 · Cited by 666 · see citing works

Fas ligand in human serum

Tanaka, M., Suda, T., Haze, K., Nakamura, N., Sato, K., Kimura, F., Motoyoshi, K., Mizuki, M., Tagawa, S., Ohga, S., et al. (1996) · Nature Medicine · doi:10.1038/nm0396-317 · Cited by 660 · see citing works

Identification of human cancers deficient in antigen processing.

Restifo, N. P., Esquivel-Guadarrama, F. R., Kawakami, Y., Yewdell, J. W., Mulé, J. J., Rosenberg, S. A., & Bennink, J. R. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.177.2.265 · Cited by 624 · see citing works

Control of c-myc Regulation in Normal and Neoplastic Cells

Spencer, C. A., & Groudine, M. T. (1991) · Advances in cancer research · doi:10.1016/s0065-230x(08)60476-5 · Cited by 612 · see citing works

Membrane Fas Ligand Kills Human Peripheral Blood T Lymphocytes, and Soluble Fas Ligand Blocks the Killing

Suda, T., Hashimoto, H., Tanaka, M., Ochi, T., & Nagata, S. (1997) · Journal of Experimental Medicine · doi:10.1084/jem.186.12.2045 · Cited by 558 · see citing works

Prevention of Islet Allograft Rejection with Engineered Myoblasts Expressing FasL in Mice

Lau, H., Yu, M., Fontana, A., & Stoeckert, C. (1996) · Science · doi:10.1126/science.273.5271.109 · Cited by 492 · see citing works

The CED-3/ICE-like Protease Mch2 Is Activated during Apoptosis and Cleaves the Death Substrate Lamin A

Orth, K., Chinnaiyan, A. M., Garg, M., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.28.16443 · Cited by 461 · see citing works

Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction

Kang, S.-M., Schneider, D. B., Lin, Z., Hanahan, D., Dichek, D. A., Stock, P. G., & Bækkeskov, S. (1997) · Nature Medicine · doi:10.1038/nm0797-738 · Cited by 448 · see citing works

Effect of bcl-2 on Fas antigen-mediated cell death.

Itoh, N., Tsujimoto, Y., & Nagata, S. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.2.621 · Cited by 434 · see citing works

CD95 ligand (FasL)-induced apoptosis is necessary for corneal allograft survival.

Stuart, P. M., Griffith, T. S., Usui, N., Pepose, J., Yu, X.-H., & Ferguson, T. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119173 · Cited by 406 · see citing works

FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway

Gulbins, E., Bissonnette, R. P., Mahboubi, A., Martin, S. J., Nishloka, W., Brunner, T., Baier, G., BALER-BITTERLICH, G., Byrd, C. A., Lang, F. J. W., et al. (1995) · Immunity · doi:10.1016/1074-7613(95)90142-6 · Cited by 399 · see citing works

Casper Is a FADD- and Caspase-Related Inducer of Apoptosis

Shu, H., Halpin, D. R., & Goeddel, D. V. (1997) · Immunity · doi:10.1016/s1074-7613(00)80450-1 · Cited by 399 · see citing works

Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain?

Saas, P., Walker, P. R., Hahne, M., Quiquerez, A., Schnüriger, V., Perrin, G., French, L. E., Meir, E. G. V., de Tribolet, N., Tschopp, J., et al. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119273 · Cited by 395 · see citing works

Human lung carcinomas express Fas ligand.

Niehans, G. A., Brunner, T., Frizelle, S. P., Liston, J. C., Salerno, C. T., Knapp, D., Green, D. R., & Kratzke, R. A. (1997) · PubMed · Cited by 395 · see citing works

CD95-Induced Apoptosis of Lymphocytes in an Immune Privileged Site Induces Immunological Tolerance

Griffith, T. S., Yu, X., Herndon, J. M., Green, D. R., & Ferguson, T. A. (1996) · Immunity · doi:10.1016/s1074-7613(00)80305-2 · Cited by 382 · see citing works

Fas antigen is the major target molecule for CD4+ T cell-mediated cytotoxicity.

Stalder, T., Hahn, S., & Erb, P. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.3.1127 · Cited by 379 · see citing works

I-FLICE, a Novel Inhibitor of Tumor Necrosis Factor Receptor-1- and CD-95-induced Apoptosis

Hu, S., Vincenz, C., Ni, J., Gentz, R., & Dixit, V. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.28.17255 · Cited by 375 · see citing works

Requirement for the CD95 Receptor-Ligand Pathway in c-Myc-Induced Apoptosis

Hueber, A., Zörnig, M., Lyon, D., Suda, T., Nagata, S., & Evan, G. I. (1997) · Science · doi:10.1126/science.278.5341.1305 · Cited by 366 · see citing works

Transgenic expression of CD95 ligand on islet β cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts

Allison, J., Georgiou, H. M., Strasser, A., & Vaux, D. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.3943 · Cited by 363 · see citing works

Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression.

Arteaga, C. L., Hurd, S. D., Winnier, A. R., Johnson, M. D., Fendly, B. M., & Forbes, J. T. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116871 · Cited by 359 · see citing works

The host—tumor immune conflict: from immunosuppression to resistance and destruction

Chouaı̈b, S., Asselin‐Paturel, C., Mami‐Chouaib, F., Caignard, A., & Blay, J. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)01115-8 · Cited by 350 · see citing works

FLAME-1, a Novel FADD-like Anti-apoptotic Molecule That Regulates Fas/TNFR1-induced Apoptosis

Srinivasula, S. M., Ahmad, M., Ottilie, S., Bullrich, F., Banks, S., Wang, Y., Fernandes‐Alnemri, T., Croce, C. M., Litwack, G., Tomaselli, K. J., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18542 · Cited by 335 · see citing works

Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin

Okura, T., Gong, L., Kamitani, T., Wada, T., Okura, I., Wei, C. F., Chang, H., & Yeh, E. T. H. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.10.4277 · Cited by 335 · see citing works

Role of Fas ligand (CD95L) in immune escape: the tumor cell strikes back

Walker, P. R., Saas, P., & Dietrich, P. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.10.4521 · Cited by 333 · see citing works

The Fas Counterattack In Vivo: Apoptotic Depletion of Tumor-Infiltrating Lymphocytes Associated with Fas Ligand Expression by Human Esophageal Carcinoma

Bennett, M., O’Connell, J., O’Sullivan, G. C., Brady, C., Roche, D., Collins, J. K., & Shanahan, F. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.11.5669 · Cited by 326 · see citing works

Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas.

Krajewska, M., Moss, S. F., Krajewski, S., Song, K. B., Holt, P. R., & Reed, J. C. (1996) · PubMed · Cited by 325 · see citing works

A CASP-8 Mutation Recognized by Cytolytic T Lymphocytes on a Human Head and Neck Carcinoma

Mandruzzato, S., Brasseur, F., Andry, G., Boon, T., & van der Bruggen, P. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.5.785 · Cited by 321 · see citing works

CASH, a Novel Caspase Homologue with Death Effector Domains

Goltsev, Y. V., Kovalenko, A., Arnold, E., Varfolomeev, E. E., Brodianskii, V. M., & Wallach, D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.32.19641 · Cited by 318 · see citing works

Costimulation of T cells for tumor immunity

Chen, L., Linsley, P. S., & Hellström, K. E. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90262-j · Cited by 315 · see citing works

Antitumor effect of locally produced CD95 ligand

Seino, K., Kayagaki, N., Okumura, K., & Yagita∥, H. (1997) · Nature Medicine · doi:10.1038/nm0297-165 · Cited by 312 · see citing works

Expression of APO‐1 (CD95), a member of the NGF/TNF receptor superfamily, in normal and neoplastic colon epithelium

Möller, P., Koretz, K., Leithäuser, F., Brüderlein, S., Henne, C., Quentmeier, A., & Krammer, P. H. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910570314 · Cited by 306 · see citing works

Unraveling Immune Privilege

Streilein, J. W. (1995) · Science · doi:10.1126/science.270.5239.1158 · Cited by 298 · see citing works

Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells.

Jäättelä, M., Benedict, M., Tewari, M., Ja, S., & Dixit, V. (1995) · PubMed · Cited by 289 · see citing works

Interferon-γ Modulates a p53-independent Apoptotic Pathway and Apoptosis-related Gene Expression

Ossina, N., Cannas, A., Powers, V. C., Fitzpatrick, P., Knight, J. D., Gilbert, J. R., Shekhtman, E. M., Tomei, L., Umansky, S. R., & Kiefer, M. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.26.16351 · Cited by 270 · see citing works

Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death.

Rodríguez, I., Matsuura, K., Ody, C., Nagata, S., & VASSALLI, P. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.5.2067 · Cited by 269 · see citing works

Fas-associated Death Domain Protein Interleukin-1β-converting Enzyme 2 (FLICE2), an ICE/Ced-3 Homologue, Is Proximally Involved in CD95- and p55-mediated Death Signaling

Vincenz, C., & Dixit, V. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.10.6578 · Cited by 256 · see citing works

Expression of Fas ligand in liver metastases of human colonic adenocarcinomas

Shiraki, K., Tsuji, N., Shioda, T., Isselbacher, K. J., & Takahashi, H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6420 · Cited by 252 · see citing works

The role of FasL-induced apoptosis in immune privilege

Griffith, T. S., & Ferguson, T. A. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)81663-5 · Cited by 251 · see citing works

Protooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation.

Weller, M., Malipiero, U., Aguzzi, A., Reed, J. C., & Fontana, A. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117965 · Cited by 250 · see citing works

Bcl-2, Bcl-xL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death

Huang, D. C. S., Cory, S., & Strasser, A. (1997) · Oncogene · doi:10.1038/sj.onc.1200848 · Cited by 246 · see citing works

CD95 (APO-1/Fas)-mediated apoptosis in colon epithelial cells: A possible role in ulcerative colitis

Sträter, J., Wellisch, I., Riedl, S., Walczak, H., Koretz, K., Tandara, A. A., Krammer, P. H., & Möller, P. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70091-x · Cited by 245 · see citing works

Divergent induction of apoptosis and IL-8 secretion in HT-29 cells in response to TNF-α and ligation of Fas antigen

Abreu-Martin, M. T., Vidrich, A., Lynch, D. H., & Targan, S. R. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.9.4147 · Cited by 241 · see citing works

Expression of the bcl‐2 gene family in normal and malignant breast tissue: Low bax‐α expression in tumor cells correlates with resistance towards apoptosis

Bargou, R. C., Daniel, P. T., Mapara, M. Y., et al. (1995) · International Journal of Cancer · doi:10.1002/ijc.2910600622 · Cited by 240 · see citing works

Lymphocyte apoptosis induced by Fas ligand- expressing ovarian carcinoma cells. Implications for altered expression of T cell receptor in tumor-associated lymphocytes.

Rabinowich, H., Reichert, T. E., Kashii, Y., Gastman, B., Bell, M. C., & Whiteside, T. L. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1518 · Cited by 235 · see citing works

Fas expression and function in normal and malignant breast cell lines.

Keane, M., Ettenberg, S. A., Lowrey, G. A., RUSSELL, E. K., & Lipkowitz, S. (1996) · PubMed · Cited by 231 · see citing works

Cotransplantation of Allogeneic Islets With Allogeneic Testicular Cell Aggregates Allows Long-Term Graft Survival Without Systemic Immunosuppression

Korbutt, G. S., Elliott, J. F., & Rajotte, R. V. (1997) · Diabetes · doi:10.2337/diab.46.2.317 · Cited by 227 · see citing works

Serological analysis of human tumor antigens: molecular definition and implications

Şahin, U., & Pfreundschuh, M. G. (1997) · Molecular Medicine Today · doi:10.1016/s1357-4310(97)01081-2 · Cited by 209 · see citing works

Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody.

Ogasawara, J., Suda, T., & Nagata, S. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.2.485 · Cited by 199 · see citing works

Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice.

Bargou, R. C., Wagener, C., Bommert, K., et al. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118715 · Cited by 193 · see citing works

Spontaneous Development of Plasmacytoid Tumors in Mice with Defective Fas–Fas Ligand Interactions

Davidson, W. F., Giese, T., & Fredrickson, T. N. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.11.1825 · Cited by 190 · see citing works

Polymorphism of murine Fas ligand that affects the biological activity

Kayagaki, N., Yamaguchi, N., Nagao, F., Matsuo, S., Maeda, H., Okumura, K., & Yagita∥, H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.3914 · Cited by 187 · see citing works

Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors

Breivik, J., Lothe, R. A., Meling, G. I., Rognum, T. O., Børresen‐Dale, A., & Gaudernack, G. (1997) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19971219)74:6 · Cited by 180 · see citing works

Messenger RNA expression of the immunosuppressive cytokine IL-10 in human gliomas.

Huettner, C. S., Paulus, W., & Roggendorf, W. (1995) · Europe PMC (PubMed Central) · Cited by 174 · see citing works

Fas/Apo-1 (CD95) receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis

Cascino, I., Papoff, G., Maria, R. D., et al. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.1.13 · Cited by 169 · see citing works

Resistance of cultured peripheral T cells towards activation‐induced cell death involves a lack of recruitment of FLICE (MACH/caspase 8) to the CD95 death‐inducing signaling complex

Peter, M. E., Kischkel, F. C., Scheuerpflug, C. G., Medema, J. P., Debatin, K., & Krammer, P. H. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270523 · Cited by 166 · see citing works

Signaling through the lymphotoxin beta receptor induces the death of some adenocarcinoma tumor lines.

Browning, J. L., Miatkowski, K., Sizing, I., Griffiths, D., Zafari, M. R., Benjamin, C. D., Meier, W., & Mackay, F. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.3.867 · Cited by 147 · see citing works

Resistance to Fas-mediated apoptosis in human hepatoma cells.

Natoli, G., Ianni, A., Costanzo, A., et al. (1995) · PubMed · Cited by 147 · see citing works

Fas Involvement in Cytotoxicity Mediated by Human NK Cells

Montel, A. H., Bochan, M. R., Hobbs, J. A., Lynch, D. H., & Brahmi, Z. (1995) · Cellular Immunology · doi:10.1006/cimm.1995.9974 · Cited by 146 · see citing works

Identification of soluble APO-1 in supernatants of human B- and T-cell lines and increased serum levels in B- and T-cell leukemias

Knipping, E., Debatin, K., Stricker, K., et al. (1995) · Blood · doi:10.1182/blood.v85.6.1562.bloodjournal8561562 · Cited by 145 · see citing works

Regulation of the Fas Apoptotic Cell Death Pathway by Abl

McGahon, A. J., Nishioka, W. K., Martin, S. J., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.38.22625 · Cited by 144 · see citing works

Fas-ligand: Privilege and peril

Green, D. R., & Ware, C. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.5986 · Cited by 142 · see citing works

The Molecular Interaction of Fas and FAP-1

Yanagisawa, J., Takahashi, M., Kanki, H., Yano-Yanagisawa, H., Tazunoki, T., Sawa, E., Nishitoba, T., Kamishohara, M., Kobayashi, E., Kataoka, S., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.13.8539 · Cited by 138 · see citing works

Fas/APO-1 gene transfer for human malignant glioma.

Weller, M., Malipiero, U., Rensing‐Ehl, A., et al. (1995) · PubMed · Cited by 127 · see citing works

Fas ligand expression in primary colon adenocarcinomas: evidence that the Fas counterattack is a prevalent mechanism of immune evasion in human colon cancer

O’Connell, J., Bennett, M., O’Sullivan, G. C., Roche, D., Kelly, J., Collins, K. J., & Shanahan, F. (1998) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199811)186:3 · Cited by 125 · see citing works

Defective expression of hematopoietic cell protein tyrosine phosphatase (HCP) in lymphoid cells blocks Fas-mediated apoptosis

Su, X., Zhou, T., Wang, Z., et al. (1995) · Immunity · doi:10.1016/1074-7613(95)90143-4 · Cited by 119 · see citing works

Production of interleukin-10 by human bronchogenic carcinoma.

Smith, D. R., Kunkel, S. L., Burdick, M. D., Wilke, C. A., Orringer, M., Whyte, R. I., & Strieter, R. M. (1994) · PubMed Central · Cited by 116 · see citing works

Interferon-γ InducesIceGene Expression and Enhances Cellular Susceptibility to Apoptosis in the U937 Leukemia Cell Line

Tamura, T., Ueda, S., Yoshida, M., et al. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1752 · Cited by 106 · see citing works

Soluble Fas/APO-1 in tumor cells: a potential regulator of apoptosis?

Owen‐Schaub, L. B., Angelo, L. S., Radinsky, R., Ware, C. F., Gesner, T. G., & Bartos, D. (1995) · Cancer Letters · doi:10.1016/0304-3835(95)03834-j · Cited by 106 · see citing works

A tumor-suppressor function for Fas (CD95) revealed in T cell-deficient mice.

Peng, S. L., Robert, M. E., Hayday, A., & Craft, J. E. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.3.1149 · Cited by 102 · see citing works

Placing death under control

Wallach, D. (1997) · Nature · doi:10.1038/40516 · Cited by 101 · see citing works

Expression of Fas/APO-1 during the progression of astrocytomas.

Tachibana, O., Nakazawa, H., Lampe, J. B., et al. (1995) · PubMed · Cited by 91 · see citing works

Induction of Fas-mediated apoptosis in p53-transfected human colon carcinoma cells.

Tamura, T., Aoyama, N., Saya, H., et al. (1995) · PubMed · Cited by 90 · see citing works

Protease inhibitors interfere with the transforming growth factor-beta-dependent but not the transforming growth factor-beta-independent pathway of tumor cell-mediated immunosuppression

Huber, D., Philipp, J., & Fontana, A. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.1.277 · Cited by 81 · see citing works

Costimulatory signals through B7.1/CD28 prevent T cell apoptosis during target cell lysis

Daniel, P. T., Kroidl, A., Cayeux, S., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.8.3808 · Cited by 77 · see citing works

Loss of Fas/Apo-1 receptor accelerates lymphomagenesis in E mu L-MYC transgenic mice but not in animals infected with MoMuLV.

Zörnig, M., Grzeschiczek, A., Kowalski, M., et al. (1995) · PubMed · Cited by 75 · see citing works

An immune suppressive factor derived from esophageal squamous carcinoma induces apoptosis in normal and transformed cells of lymphoid lineage.

O'Mahony, A. M., O’Sullivan, G. C., O’Connell, J., et al. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.9.4847 · Cited by 71 · see citing works

Rejection of MHC class II-transfected tumor cells requires induction of tumor-encoded B7-1 and/or B7-2 costimulatory molecules

Baskar, S., Clements, V. K., Glimcher, L. H., et al. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.10.3821 · Cited by 70 · see citing works

The Fas Counterattack: A Molecular Mechanism of Tumor Immune Privilege

O’Connell, J., Bennett, M., O’Sullivan, G. C., Collins, J. K., & Shanahan, F. (1997) · Molecular Medicine · doi:10.1007/bf03401808 · Cited by 62 · see citing works

New tumor antigens recognized by T cells

den Eynde, B. V., & Brichard, V. G. (1995) · Current Opinion in Immunology · doi:10.1016/0952-7915(95)80076-x · Cited by 62 · see citing works

T cell receptor-zeta and granzyme B expression in mononuclear cell infiltrates in normal colon mucosa and colon carcinoma.

Mulder, W. M. C., Bloemena, E., Stukart, M. J., et al. (1997) · Gut · doi:10.1136/gut.40.1.113 · Cited by 60 · see citing works

REVIEW ARTICLE. p53: GUARDIAN OF CELLULAR SENESCENCE

Wynford‐Thomas, D. (1996) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199610)180:2 · Cited by 59 · see citing works

A Myc-Induced Apoptosis Pathway Surfaces

Green, D. R. (1997) · Science · doi:10.1126/science.278.5341.1246 · Cited by 51 · see citing works

Expression of the co‐stimulatory molecule B7 on melanoma cells

Hersey, P., Si, Z., Smith, M. J., & Thomas, W. D. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910580413 · Cited by 51 · see citing works

Expression of FAP-1 (Fas-Associated Phosphatase) and Resistance to Fas-Mediated Apoptosis in T Cell Lines Derived from Human T Cell Leukemia Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis Patients

Arai, M., Kannagi, M., Matsuoka, M., et al. (1998) · AIDS Research and Human Retroviruses · doi:10.1089/aid.1998.14.261 · Cited by 50 · see citing works

Expression of Fas(APO-1/CD95) in tumor-infiltrating and peripheral blood lymphocytes in patients with renal cell carcinoma.

Cardi, G., Heaney, J. A., Schned, A. R., et al. (1998) · PubMed · Cited by 49 · see citing works

FasL — Too much of a good thing?

Lau, H., & Stoeckert, C. (1997) · Nature Medicine · doi:10.1038/nm0797-727 · Cited by 45 · see citing works

TCR in Fas-sensitive T cells from labial salivary glands of patients with Sjögren's syndrome

Sumida, T., Matsumoto, I., Murata, H., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.2.1020 · Cited by 43 · see citing works

Regional immunosuppression in esophageal squamous cancer: evidence from functional studies with matched lymph nodes

O’Sullivan, G. C., Corbett, A. R., Shanahan, F., et al. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.10.4717 · Cited by 41 · see citing works

Human glioblastoma cell derived transforming growth factor-β2: evidence for secretion of both high and low molecular weight biologically active forms

Bodmer, S., Huber, D. A., Heid, I., et al. (1991) · Journal of Neuroimmunology · doi:10.1016/0165-5728(91)90096-p · Cited by 41 · see citing works

Cellular characteristics of peripheral blood lymphocytes and tumour-infiltrating lymphocytes in patients with gynaecological tumours

Schöndorf, T., Engel, H., Lindemann, C., Kolhagen, H., von Rücker, A. A., & Mallmann, P. K. (1997) · Cancer Immunology Immunotherapy · doi:10.1007/s002620050360 · Cited by 40 · see citing works

Molecular and functional phenotypes of melanoma cells with abnormalities in HLA Class I antigen expression

Wang, Z., Margulies, L., Hicklin, D. J., et al. (1996) · Tissue Antigens · doi:10.1111/j.1399-0039.1996.tb02573.x · Cited by 38 · see citing works

Thyroiditis and hepatitis: Fas on the road to disease

French, L. E., & Tschopp, J. (1997) · Nature Medicine · doi:10.1038/nm0497-387 · Cited by 38 · see citing works

T cell receptor of Fas-sensitive T cells in rheumatoid synovium

Sumida, T., Hoa, T. T. M., Asahara, H., Hasunuma, T., & Nishioka, K. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.4.1965 · Cited by 30 · see citing works

Biosynthesis and shedding of murine lymphoma gangliosides

Li, R., Gage, D. A., & Ladisch, S. (1993) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(93)90011-w · Cited by 30 · see citing works

A Computer-Aided Radiopharmaceutical Drug Design Study Using Ab Initio and Molecular Mechanics Methods

Kirby, R. A., & Pollak, A. (1997) · Journal of Molecular Modeling · doi:10.1007/s008940050040 · Cited by 29 · see citing works

Gangliosides and antitumor immunity

Bergelson, L. D. (1993) · Journal of Molecular Medicine · doi:10.1007/bf00184480 · Cited by 21 · see citing works

Cell Death and the Immune Response: A Lesson from the Privileged

Ferguson, T. A., & Griffith, T. S. (1997) · Journal of Clinical Immunology · doi:10.1023/a:1027343210080 · Cited by 16 · see citing works

Deacetylase activity of human tumor cells producing immunosuppressive aminosugars: its possible role in resistance to cell-mediated cytotoxicity.

Yagita, M., Seppo, A., Renkonen, O., et al. (1993) · PubMed · Cited by 16 · see citing works

Signals from lymphocytes in colon cancer.

Kiessling, R. W. (1997) · Gut · doi:10.1136/gut.40.1.153 · Cited by 9 · see citing works

Tumor-Infiltrating Macrophages Induce Apoptosis in Activated CD8+ T Cells by a Mechanism Requiring Cell Contact and Mediated by Both the Cell-Associated Form of TNF and Nitric Oxide

Saio, M., Radoja, S., Marino, M., & Frey, A. B. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.10.5583 · Cited by 157 · see citing works

Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy

Nikolouzakis, T. K., Chrysos, E., Docea, A. O., Fragkiadaki, P., Souglakos, J., Tsiaoussis, J., & Tsatsakis, A. (2024) · Cancers · doi:10.3390/cancers16111995 · Cited by 37 · see citing works

Role of Fas Ligand in Ocular Tissue

Sano, Y., & Sotozono, C. (2002) · Cornea · doi:10.1097/00003226-200203001-00007 · Cited by 6 · see citing works

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

Griffith, T. S., Brunner, T., Fletcher, S. M., Green, D. R., & Ferguson, T. A. (1995) · Science · doi:10.1126/science.270.5239.1189 · Cited by 1,990 · see citing works

CD95 ligand (FasL)-induced apoptosis is necessary for corneal allograft survival.

Stuart, P. M., Griffith, T. S., Usui, N., Pepose, J., Yu, X.-H., & Ferguson, T. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119173 · Cited by 406 · see citing works

ROLE OF FAS-FAS LIGAND INTERACTIONS IN THE IMMUNOREJECTION OF ALLOGENEIC MOUSE CORNEAL TRANSPLANTS1

Yamagami, S., Kawashima, H., Tsuru, T., Yamagami, H., Kayagaki, N., Yagita∥, H., Okumura, K., & Gregerson, D. S. (1997) · Transplantation · doi:10.1097/00007890-199710270-00004 · Cited by 142 · see citing works

Membrane Fas Ligand Activates Innate Immunity and Terminates Ocular Immune Privilege

Gregory, M. S., Repp, A. C., Hohlbaum, A. M., Saff, R. R., Marshak‐Rothstein, A., & Ksander, B. R. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.5.2727 · Cited by 84 · see citing works