The proto-oncogene Bcl-2 and its role in regulating apoptosis
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The intrinsic pathway involved in UVR-induced apoptosis results from DNA damage and cytochrome c release from mitochondria.
“The intrinsic pathway involved in UVR-induced apoptosis results from DNA damage and cytochrome c release from mitochondria (Figure 2) [39,40].”
From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [39]
The balance of pro-apoptotic (Bax, Bak and Bid) and anti-apoptotic (Bcl-2 and Bcl-x) members of the Bcl-2 protein family determines the initiation or the inhibition of apoptosis.
“The balance of pro-apoptotic (Bax, Bak and Bid) and anti-apoptotic (Bcl-2 and Bcl-x) members of the Bcl-2 protein family determine the initiation or the inhibition of apoptosis [39].”
From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [39]
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- Authors
- Kroemer, G.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Kroemer, Guido
- ORCID
- Kroemer, Guido
- Venue
- Nature Medicine
- Published
- 1997-06-01
- Volume
- 3
- Issue
- 6
- Pages
- 614-620
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2070862399
- Cited by
- 1,739
- References
- 0
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 4 · 2023: 11 · 2022: 17 · 2021: 15 · 2020: 25 · 2019: 20 · 2018: 15 · 2017: 25 · 2016: 18 · 2015: 35 · 2014: 35 · 2013: 35 · 2012: 37
- FWCI
- 15.50
- Type
- journal article
- Language
- en
- Update notices
- correction (1997-08-01)
- Open access
- closed
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Health Sciences › Medicine › Oncology › Clusterin in disease pathology
- Keywords
- Bcl-2, proto-oncogenes, apoptosis regulation, anti-apoptotic proteins, cancer therapy
- MeSH terms
- Animals, Cell-Free System, Membrane Proteins, Mitochondria, Proto-Oncogene Proteins, Structure-Activity Relationship, Apoptosis, Proto-Oncogene Proteins c-bcl-2, bcl-2 Homologous Antagonist-Killer Protein, bcl-2-Associated X Protein
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