The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Signal-transduction cascades as targets for therapeutic intervention by natural products
Abstract
Many bacteria and fungi produce natural products that are toxic to other microorganisms and have a variety of physiological effects in animals. Recent studies have revealed that, in several cases, the targets of these agents are components of conserved signal-transduction cascades. This article looks at the mechanisms of action of five natural products--the immunosuppressants cyclosporin A, FK506 and rapamycin, and the antiproliferative agents wortmannin and geldanamycin. These mechanisms reveal the importance of signal-transduction cascades as targets for therapeutic intervention and the enormous utility of studies of natural-product action in simple model genetic systems.
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“Geldanamycin is a natural fermentation product of the benzoquinone ansamycin and inhibits the heat shock protein HSP90 [220], as well show cytotoxic effect against HeLa cells [221].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [220]
Citations
Cites
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Microbial drug discovery: 80 years of progress
Demain, A. L., & Sánchez, S. (2009) · The Journal of Antibiotics · doi:10.1038/ja.2008.16 · Cited by 1,004
Hypoxia, Clonal Selection, and the Role of HIF-1 in Tumor Progression
Semenza, G. L. (2000) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230091169186 · Cited by 657
Natural products in anticancer therapy
Ab, D. R. (2001) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(01)00063-7 · Cited by 618
SU6656, a Selective Src Family Kinase Inhibitor, Used To Probe Growth Factor Signaling
Blake, R. A., Broome, M. A., Liu, X., Wu, J., Gishizky, M. L., Sun, L., & Courtneidge, S. A. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.9018-9027.2000 · Cited by 580
The TOR signaling cascade regulates gene expression in response to nutrientsPreprint
Cardenas, M. E., Cutler, N. S., Lorenz, M. C., Como, C. J. D., & Heitman, J. (1999) · Genes & Development · doi:10.1101/gad.13.24.3271 · Cited by 580
Self-citation
Metadata
- Authors
- Cardenas, M. E., Sanfridson, A., Cutler, N. S., & Heitman, J.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Heitman, Joseph
- Venue
- Trends in Biotechnology
- Publisher
- Elsevier BV
- Published
- 1998-10
- Volume
- 16
- Issue
- 10
- Pages
- 427-433
- ISSN
- 0167-7799 (ISSN-L)
- OpenAlex
- W1968232511
- Cited by
- 101
- References
- 72
- Citations by year
- 2023: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 1 · 2014: 7 · 2013: 3 · 2012: 1
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ai041937-03, 5k01ca077075-04)
- National Cancer Institute (KO1 CA77075)
- National Institute of Allergy and Infectious Diseases (AI 39115, AI41937)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- signaling pathways, natural products, microbial secondary metabolites, cyclosporine, FK506, rapamycin, wortmannin, geldanamycin, immunosuppressants, antiproliferative agents, mechanism of action, target-based drug discovery
- MeSH terms
- Wortmannin, Androstadienes, Animals, Cell Cycle, Enzyme Inhibitors, Fungi, Humans, Immunosuppressive Agents, Quinones, Protein Biosynthesis, Signal Transduction, Benzoquinones, Tacrolimus, Cyclosporine, Apoptosis, HSP90 Heat-Shock Proteins, Calcineurin, Sirolimus, Lactams, Macrocyclic
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