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TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

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PI3K: Downstream AKTion Blocks Apoptosis

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Cryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformans

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Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.

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Isolation of a Protein Target of the FKBP12-Rapamycin Complex in Mammalian Cells

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Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

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Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin

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DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

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Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

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Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3‐kinase inhibitors, wortmannin and LY294002.

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Wortmannin Inactivates Phosphoinositide 3-Kinase by Covalent Modification of Lys-802, a Residue Involved in the Phosphate Transfer Reaction

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Cyclosporin A, FK-506, and Rapamycin: Pharmacologic Probes of Lymphocyte Signal Transduction

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A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits

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Regulation of eIF-4E BP1 Phosphorylation by mTOR

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Calcineurin is required for virulence of Cryptococcus neoformans

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RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex.

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Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase.

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Wortmannin, a microbial product inhibitor of myosin light chain kinase.

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TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast.

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A Signaling Pathway to Translational Control

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Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

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Dominant Missense Mutations in a Novel Yeast Protein related to Mammalian Phosphatidylinositol 3-Kinase and VPS34 Abrogate Rapamycin Cytotoxicity

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DIFFERENTIAL SIGNALING BY LYMPHOCYTE ANTIGEN RECEPTORS

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Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities.

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TOR Mutations Confer Rapamycin Resistance by Preventing Interaction with FKBP12-Rapamycin

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4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase.

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Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: An alternative route to mitogen-induced gene expression

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Rapamycin enhances apoptosis and increases sensitivity to cisplatin in vitro.

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A Cyclophilin Function in Hsp90-Dependent Signal Transduction

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Rapamycin Resistance Tied to Defective Regulation of p27 Kip1

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Cloning and Characterization of a Wortmannin-sensitive Human Phosphatidylinositol 4-Kinase

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The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein

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FKBP12‐rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol‐4 kinase activity.

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A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3‐kinase

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The Rapamycin and FKBP12 Target (RAFT) Displays Phosphatidylinositol 4-Kinase Activity

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Wortmannin Inhibits Mitogen-activated Protein Kinase Activation by Platelet-activating Factor through a Mechanism Independent of p85/p110-type Phosphatidylinositol 3-Kinase

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STT4 Is an Essential Phosphatidylinositol 4-Kinase That Is a Target of Wortmannin in Saccharomyces cerevisiae

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Golgi Localization in Yeast Is Mediated by the Membrane Anchor Region of Rat Liver Sialyltransferase

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vph6 mutants of Saccharomyces cerevisiae require calcineurin for growth and are defective in vacuolar H(+)-ATPase assembly.

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Improved calcineurin inhibition by yeast FKBP12-drug complexes. Crystallographic and functional analysis.

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Mammalian RAFT1 kinase domain provides rapamycin-sensitive TOR function in yeast.Preprint

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Calcineurin mutants render T lymphocytes resistant to cyclosporin A.

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Mutations That Perturb Cyclophilin A Ligand Binding Pocket Confer Cyclosporin A Resistance in Saccharomycescerevisiae

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Effects of rapamycin on apoptosis of rheumatoid synovial cells

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Wortmannin Inhibits the Production of Reactive Oxygen and Nitrogen Intermediates and the Killing of theSaccharomyces Cerevzsaeby Isolated Chicken Macrophages

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Hypoxia, Clonal Selection, and the Role of HIF-1 in Tumor Progression

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SU6656, a Selective Src Family Kinase Inhibitor, Used To Probe Growth Factor Signaling

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Identification of Immunosuppressive Drug Targets in Yeast

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