Heitman, Joseph

Evolution of pathogenicity and sexual reproduction in eight Candida genomes

Butler, G., Rasmussen, M. D., Lin, M. F., Santos, M. A. S., Sakthikumar, S., Munro, C. A., Rheinbay, E., Grabherr, M., Forche, A., Reedy, J. L., et al. (2009) · Nature

Fungal and yeast genetics researchYeasts and Rust Fungi Studies

Cited by 1,065

Signal Transduction Cascades Regulating Fungal Development and Virulence

Lengeler, K. B., Davidson, R. C., D'souza, C., Harashima, T., Shen, W.-C., Wang, P., Pan, X., Waugh, M., & Heitman, J. (2000) · Microbiology and Molecular Biology Reviews

Fungal and yeast genetics researchFungal Infections and Studies

Cited by 915

A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans

Liu, L., Hausladen, A., Zeng, M., Que, L., Heitman, J., & Stamler, J. S. (2001) · Nature

Redox biology and oxidative stressNitric Oxide and Endothelin Effects

Cited by 913

Calcineurin is required for virulence of Cryptococcus neoformans

Odom, A., Muir, S., Lim, E., Toffaletti, D. L., Perfect, J., & Heitman, J. (1997) · The EMBO Journal

Fungal Infections and StudiesSignaling Pathways in Disease

Cited by 516

Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak

Fraser, J. A., Giles, S. S., Wenink, E. C., Geunes-Boyer, S. G., Wright, J. R., Diezmann, S., Allen, A., Stajich, J. E., Dietrich, F. S., Perfect, J. R., et al. (2005) · Nature

Fungal Infections and StudiesPlant Pathogens and Fungal Diseases

Cited by 499

Cryptococcal cell morphology affects host cell interactions and pathogenicity

Okagaki, L. H., Strain, A. K., Nielsen, J. N., Charlier, C., Baltes, N. J., Chrétien, F., Heitman, J., Dromer, F., & Nielsen, K. (2010) · PLoS Pathogens

Fungal Infections and StudiesAntifungal resistance and susceptibility

Cited by 345

Calcineurin is essential for survival during membrane stress in Candida albicans

Cruz, M. C., Goldstein, A. L., Blankenship, J. R., Del Poeta, M., Davis, D., Cardenas, M. E., Perfect, J. R., McCusker, J. H., & Heitman, J. (2002) · The EMBO Journal

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 342

Emergence and pathogenicity of highly virulent Cryptococcus gattii genotypes in the northwest United States

Byrnes, E. J., Li, W., Lewit, Y., Ma, H., Voelz, K., Ren, P., Carter, D. A., Chaturvedi, V., Bildfell, R. J., May, R. C., et al. (2010) · PLoS Pathogens

Fungal Infections and StudiesPlant Pathogens and Fungal Diseases

Cited by 330

Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections.

Steinbach, W. J., Reedy, J. L., Cramer, R. A., Perfect, J. R., & Heitman, J. (2007) · Nature Reviews Microbiology

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 313

Hsp90 Orchestrates Temperature-Dependent Candida albicans Morphogenesis via Ras1-PKA Signaling

Shapiro, R. S., Uppuluri, P., Zaas, A. K., Collins, C., Senn, H., Perfect, J. R., Heitman, J., & Cowen, L. E. (2009) · Current Biology

Fungal and yeast genetics researchHeat shock proteins research

Cited by 311

Ergosterol Biosynthesis Inhibitors Become Fungicidal when Combined with Calcineurin Inhibitors against Candida albicans , Candida glabrata , and Candida krusei

Onyewu, C., Blankenship, J. R., Del Poeta, M., & Heitman, J. (2003) · Antimicrobial Agents and Chemotherapy

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 282

Calcineurin Controls Growth, Morphology, and Pathogenicity in Aspergillus fumigatus

Steinbach, W. J., Cramer, R. A., Perfect, B. Z., Asfaw, Y. G., Sauer, T. C., Najvar, L. K., Kirkpatrick, W. R., Patterson, T. F., Benjamin, D. K., Heitman, J., et al. (2006) · Eukaryotic Cell

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 264

Synergistic Effect of Calcineurin Inhibitors and Fluconazole against Candida albicans Biofilms

Uppuluri, P., Nett, J., Heitman, J., & Andes, D. (2008) · Antimicrobial Agents and Chemotherapy

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 228

Calcineurin: Structure, function, and inhibition

Hemenway, C. S., & Heitman, J. (1999) · Cell Biochemistry and Biophysics

Signaling Pathways in DiseaseProtein Structure and Dynamics

Cited by 227

The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function

Kraus, P. R., Fox, D. S., Cox, G. M., & Heitman, J. (2003) · Molecular Microbiology

Fungal Infections and StudiesFungal and yeast genetics research

Cited by 217

Carbonic Anhydrase and CO2 Sensing during Cryptococcus neoformans Growth, Differentiation, and Virulence

Bahn, Y.-S., Cox, G. M., Perfect, J. R., & Heitman, J. (2005) · Current Biology

Fungal Infections and StudiesEnzyme function and inhibition

Cited by 205

Genome variation in Cryptococcus gattii, an emerging pathogen of immunocompetent hosts

D’Souza, C. A., Kronstad, J. W., Taylor, G., Warren, R., Yuen, M., Hu, G., Jung, W. H., Sham, A., Kidd, S. E., Tangen, K., et al. (2011) · mBio

Fungal Infections and StudiesPlant Pathogens and Fungal Diseases

Cited by 202

Drug-Resistant Epimutants Exhibit Organ-Specific Stability and Induction during Murine Infections Caused by the Human Fungal Pathogen Mucor circinelloides

Chang, Z., & Heitman, J. (2019) · mBio

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 202

Calcineurin Is Essential for Candida albicans Survival in Serum and Virulence

Blankenship, J. R., Wormley, F. L., Boyce, M. K., Schell, W. A., Filler, S. G., Perfect, J. R., & Heitman, J. (2003) · Eukaryotic Cell

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 186

Cryptococcus neoformans copper detoxification machinery is critical for fungal virulence

Ding, C., Festa, R. A., Chen, Y.-L., Espart, A., Palacios, Ò., Espín, J., Capdevila, M., Atrian, S., Heitman, J., & Thiele, D. J. (2013) · Cell Host & Microbe

Fungal Infections and StudiesTrace Elements in Health

Cited by 179

Antifungal drug resistance evoked via RNAi-dependent epimutations

Calo, S., Shertz-Wall, C., Lee, S. C., Bastidas, R. J., Nicolás, F. E., Granek, J. A., Mieczkowski, P., Torres-Martínez, S., Ruiz-Vázquez, R. M., Cardenas, M. E., et al. (2014) · Nature

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 175

Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12–FK506 in Cryptococcus neoformans

Fox, D. S., Cruz, M. C., Sia, R. A. L., Ke, H., Cox, G. M., Cardenas, M. E., & Heitman, J. (2001) · Molecular Microbiology

Fungal Infections and StudiesSignaling Pathways in Disease

Cited by 175

Calcineurin Target CrzA Regulates Conidial Germination, Hyphal Growth, and Pathogenesis of Aspergillus fumigatus

Cramer, R. A., Perfect, B. Z., Pinchai, N., Park, S., Perlin, D. S., Asfaw, Y. G., Heitman, J., Perfect, J. R., & Steinbach, W. J. (2008) · Eukaryotic Cell

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 172

Coping with stress: calmodulin and calcineurin in model and pathogenic fungi

Kraus, P. R., & Heitman, J. (2003) · Biochemical and Biophysical Research Communications

Fungal and yeast genetics researchSignaling Pathways in Disease

Cited by 169