Functional roles of protein interactions with AMPA and kainate receptors
Abstract
The glutamate receptor subtypes AMPA and kainate are involved in synaptic transmission and synaptic plasticity in the CNS. Recently there has been considerable interest in understanding the molecular regulation of these receptors by proteins that directly bind to AMPA and kainate receptor subunits. Amongst the first interaction partners to be discovered were NSF, ABP, GRIP and PICK1, which bind the AMPA receptor subunit GLUA2. We have studied the functional roles of the interactions of these proteins in regulating AMPA receptor-mediated synaptic transmission and synaptic plasticity in the hippocampus. We have also started to investigate the functions of PICK1 and GRIP on kainate receptor-mediated synaptic transmission in this region. In this article we reflect upon this work, which has led to some new ideas about how AMPA and kainate receptors are regulated at synapses.
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If interactions with scaffolding proteins are manipulated through genetic interventions or the perfusion of dominant-negative proteins, LTP and LTD can be blocked.
“If interactions with scaffolding proteins are manipulated through genetic interventions or the perfusion of dominant-negative proteins, LTP and LTD can be blocked (Lu ¨scher et al. 1999;Lu ¨thi et al. 1999;Collingridge and Isaac 2003).”
From NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012) · cites this paper as Collingridge and Isaac 2003
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Subunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons
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Regulation of Synaptic Strength by Protein Phosphatase 1
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NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD).
Luscher, C., & Malenka, R. C. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005710 · Cited by 1,110 · see citing works
- Authors
- Collingridge, G. L., & Isaac, J. T. R.
- Affiliations
- University of British Columbia (CA)
- University of Bristol (GB)
- Corresponding author
- Collingridge, Graham L.
- Venue
- Neuroscience Research
- Publisher
- Elsevier BV
- Published
- 2003-09
- Volume
- 47
- Issue
- 1
- Pages
- 3-15
- ISSN
- 0168-0102 (ISSN-L)
- OpenAlex
- W2059146082
- Cited by
- 45
- References
- 4
- Citations by year
- 2022: 2 · 2021: 2 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 3
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Wellcome Trust
- Biotechnology and Biological Sciences Research Council
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- AMPA receptors, kainate receptors, glutamate receptors, protein-protein interaction, NSF, ABP, grip, PICK1, GluA2, synaptic transmission, synaptic plasticity, hippocampus
- MeSH terms
- Animals, Humans, Neurons, Protein Binding, Synapses, Receptors, AMPA, Kainic Acid Receptors, Receptors, Kainic Acid, Excitatory Postsynaptic Potentials
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