Postsynaptic contribution to long-term potentiation revealed by the analysis of miniature synaptic currents

Manabe, Toshiya; Renner, Pius; Nicoll, Roger A.

doi:10.1038/355050a0

Cited by 366Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeural dynamics and brain function

Postsynaptic contribution to long-term potentiation revealed by the analysis of miniature synaptic currents

Manabe, Toshiya, Renner, Pius, Nicoll, Roger A.·1992·Nature

DOI 10.1038/355050a0

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Abstract

Miniature excitatory synaptic currents were recorded from CA1 pyramidal cells in hippocampal slices to study the site of the persistent change in synaptic efficacy during long-term potentiation. Induction of long-term potentiation produced a large increase in the amplitude of these currents. Such a change in amplitude suggests an increase in postsynaptic transmitter sensitivity.

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The size of quantal miniature EPSCs increases after LTP.
“For instance, the size of “quantal” miniature EPSCs increases after LTP (364, 365).”
From Synaptic memory and CaMKII (2023) · cites this paper as [365]

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Authors: Manabe, T., Renner, P., & Nicoll, R. A.
Affiliations: University of California, San Francisco (US)
ORCID: Manabe, Toshiya
Nicoll, Roger A.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1992-01
Volume: 355
Issue: 6355
Pages: 50-55
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/355050a0
OpenAlex: W1970096704
Cited by: 366
References: 35
Citations by year: 2026: 1 · 2025: 3 · 2024: 6 · 2023: 1 · 2022: 5 · 2021: 7 · 2020: 4 · 2019: 2 · 2018: 8 · 2017: 3 · 2016: 6 · 2015: 6 · 2014: 6 · 2013: 4 · 2012: 3
FWCI: 22.01
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: long-term potentiation, miniature synaptic currents, CA1 pyramidal neurons, hippocampus, synaptic efficacy, excitatory synaptic transmission
MeSH terms: Animals, Electric Stimulation, Evoked Potentials, Hippocampus, Pyramidal Tracts, Quinoxalines, Synapses, Tetrodotoxin, N-Methylaspartate, 6-Cyano-7-nitroquinoxaline-2,3-dione, In Vitro Techniques

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Postsynaptic contribution to long-term potentiation revealed by the analysis of miniature synaptic currents

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