The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Drug delivery in pluronic micelles: effect of high-frequency ultrasound on drug release from micelles and intracellular uptake
Open accessAbstract
The effect of high-frequency ultrasound on doxorubicin (DOX) release from Pluronic micelles and intracellular DOX uptake was studied for promyelocytic leukemia HL-60 cells, ovarian carcinoma drug-sensitive and multidrug-resistant (MDR) cells (A2780 and A2780/ADR, respectively), and breast cancer MCF-7 cells. Cavitation events initiated by high-frequency ultrasound were recorded by radical trapping. The onset of transient cavitation and DOX release from micelles were observed at much higher power densities than at low-frequency ultrasound (20-100 kHz). Even a short (15-30 s) exposure to high-frequency ultrasound significantly enhanced the intracellular DOX uptake from PBS, RPMI 1640, and Pluronic micelles. The mechanisms of the observed effects are discussed.
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“The study showed increased DOX release under high-frequency ultrasound [206].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [206]
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Bioadhesive‐Based Dosage Forms: The Next Generation
Lee, J. W., Park, J. H., & Robinson, J. R. (2000) · Journal of Pharmaceutical Sciences · doi:10.1002/1520-6017(200007)89:7 · Cited by 594
Induction of cell-membrane porosity by ultrasound
Tachibana, K., Uchida, T., Ogawa, K., Yamashita, N., & Tamura, K. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01244-1 · Cited by 450
Factors affecting acoustically triggered release of drugs from polymeric micelles
Husseini, G. A., Myrup, G. D., Pitt, W. G., Christensen, D. A., & Rapoport, N. Y. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00278-9 · Cited by 230
Molecular emission from single-bubble sonoluminescence
Didenko, Y. T., McNamara, W. B., & Suslick, K. S. (2000) · Nature · doi:10.1038/35038020 · Cited by 210
Stabilization and activation of Pluronic micelles for tumor-targeted drug delivery
Rapoport, N. Y. (1999) · Colloids and Surfaces B Biointerfaces · doi:10.1016/s0927-7765(99)00063-6 · Cited by 182
Sonophoresis. II. Examination of the Mechanism(s) of Ultrasound-Enhanced Transdermal Drug Delivery
Bommannan, D. B., Menon, G. K., Okuyama, H., Elias, P. M., & Guy, R. H. (1992) · Pharmaceutical Research · doi:10.1023/a:1015806528336 · Cited by 166
Determination of threshold energy dose for ultrasound-induced transdermal drug transport
Mitragotri, S., Farrell, J. M., Tang, H., Terahara, T., Kost, J., & Langer, R. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00178-9 · Cited by 160
Sonophoresis. I. The Use of High-Frequency Ultrasound to Enhance Transdermal Drug Delivery
Bommannan, D. B., Okuyama, H., Stauffer, P. R., & Guy, R. H. (1992) · Pharmaceutical Research · doi:10.1023/a:1015808917491 · Cited by 143
Rapoport, N. Y., Marin, A., Luo, Y., Prestwich, G. D., & Muniruzzaman, M. (2002) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.10006 · Cited by 128
Rapoport, N. Y., Herron, J. N., Pitt, W. G., & Pitina, L. (1999) · Journal of Controlled Release · doi:10.1016/s0168-3659(98)00149-7 · Cited by 124
Research works printed but not linked: 1
- Rapoport, 1997, Pluronic micelles as vehicles for tumor-specific delivery of two anticancer drugs to HL-60 cells using acoustic activation, Polym. Preprints, 38, 620
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Block copolymer micelles in nanomedicine applications
Cabral, H., Miyata, K., Osada, K., & Kataoka, K. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00199 · Cited by 1,309
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Adams, M. L., Lavasanifar, A., & Kwon, G. S. (2003) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.10397 · Cited by 1,078
Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release
Oerlemans, C., Bult, W., Bos, M. A., Storm, G., Nijsen, J. F. W., & Hennink, W. E. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0233-4 · Cited by 969
Advances in polymeric micelles for drug delivery and tumor targeting
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Metadata
- Authors
- Marin, A., Sun, H., Husseini, G. A., Pitt, W. G., Christensen, D. A., & Rapoport, N. Y.
- Affiliations
- University of Utah (US)
- Brigham Young University (US)
- Corresponding author
- Rapoport, Natalya Y
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2002-11
- Volume
- 84
- Issue
- 1-2
- Pages
- 39-47
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W1969929756
- Cited by
- 213
- References
- 25
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 2 · 2022: 3 · 2021: 8 · 2020: 7 · 2019: 8 · 2018: 12 · 2017: 8 · 2016: 12 · 2015: 8 · 2014: 13 · 2013: 21 · 2012: 17
- FWCI
- 5.36
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- DSpace at AUS (American University of Sharjah) (acceptedVersion)
- DSpace at AUS (American University of Sharjah) (submittedVersion)
- Funders
- National Institutes of Health (5r01ca076562-03)
- National Cancer Institute (CA 76562)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Physics and Astronomy › Acoustics and Ultrasonics › Ultrasound and Cavitation Phenomena
- Keywords
- Pluronic micelles, high-frequency ultrasound, doxorubicin, drug release, intracellular drug uptake, cavitation, multidrug resistance, ovarian carcinoma, breast cancer, HL-60 cells, MCF-7 cells, power density
- MeSH terms
- Algorithms, Antibiotics, Antineoplastic, Breast Neoplasms, Doxorubicin, Electron Spin Resonance Spectroscopy, Excipients, Female, Flow Cytometry, Humans, Micelles, Ovarian Neoplasms, Spectrometry, Fluorescence, Surface Properties, Ultrasonics, Leukemia, Promyelocytic, Acute, Drug Delivery Systems, HL-60 Cells, Poloxamer
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