Cited by 213Ultrasound and Hyperthermia ApplicationsNanoparticle-Based Drug DeliveryUltrasound and Cavitation Phenomena

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Drug delivery in pluronic micelles: effect of high-frequency ultrasound on drug release from micelles and intracellular uptake

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Marin, Alexandre, Sun, Hao, Husseini, Ghaleb A, Pitt, William G, Christensen, Douglas A, Rapoport, Natalya Y·2002·Journal of Controlled Release

DOI 10.1016/s0168-3659(02)00262-6

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Abstract

The effect of high-frequency ultrasound on doxorubicin (DOX) release from Pluronic micelles and intracellular DOX uptake was studied for promyelocytic leukemia HL-60 cells, ovarian carcinoma drug-sensitive and multidrug-resistant (MDR) cells (A2780 and A2780/ADR, respectively), and breast cancer MCF-7 cells. Cavitation events initiated by high-frequency ultrasound were recorded by radical trapping. The onset of transient cavitation and DOX release from micelles were observed at much higher power densities than at low-frequency ultrasound (20-100 kHz). Even a short (15-30 s) exposure to high-frequency ultrasound significantly enhanced the intracellular DOX uptake from PBS, RPMI 1640, and Pluronic micelles. The mechanisms of the observed effects are discussed.

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Authors: Marin, A., Sun, H., Husseini, G. A., Pitt, W. G., Christensen, D. A., & Rapoport, N. Y.
Affiliations: University of Utah (US)
Brigham Young University (US)
Corresponding author: Rapoport, Natalya Y
ORCID: Sun, Hao
Husseini, Ghaleb A
Pitt, William G
Venue: Journal of Controlled Release
Publisher: Elsevier BV
Published: 2002-11
Volume: 84
Issue: 1-2
Pages: 39-47
ISSN: 0168-3659 (ISSN-L)
DOI: 10.1016/s0168-3659(02)00262-6
OpenAlex: W1969929756
Cited by: 213
References: 25
Citations by year: 2026: 2 · 2025: 5 · 2024: 5 · 2023: 2 · 2022: 3 · 2021: 8 · 2020: 7 · 2019: 8 · 2018: 12 · 2017: 8 · 2016: 12 · 2015: 8 · 2014: 13 · 2013: 21 · 2012: 17
FWCI: 5.36
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Controlled Release (publishedVersion)
PubMed (publishedVersion)
DSpace at AUS (American University of Sharjah) (acceptedVersion)
DSpace at AUS (American University of Sharjah) (submittedVersion)
Funders: National Institutes of Health (5r01ca076562-03)
National Cancer Institute (CA 76562)
Topics: Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Physical Sciences › Physics and Astronomy › Acoustics and Ultrasonics › Ultrasound and Cavitation Phenomena
Keywords: Pluronic micelles, high-frequency ultrasound, doxorubicin, drug release, intracellular drug uptake, cavitation, multidrug resistance, ovarian carcinoma, breast cancer, HL-60 cells, MCF-7 cells, power density
MeSH terms: Algorithms, Antibiotics, Antineoplastic, Breast Neoplasms, Doxorubicin, Electron Spin Resonance Spectroscopy, Excipients, Female, Flow Cytometry, Humans, Micelles, Ovarian Neoplasms, Spectrometry, Fluorescence, Surface Properties, Ultrasonics, Leukemia, Promyelocytic, Acute, Drug Delivery Systems, HL-60 Cells, Poloxamer

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Drug delivery in pluronic micelles: effect of high-frequency ultrasound on drug release from micelles and intracellular uptake

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