964 THE FARNESOID X RECEPTOR (FXR) AGONIST OBETICHOLIC ACID (OCA) INCREASES PLASMA FGF-19 CONCENTRATIONS AND DECREASES BILE ACID SYNTHESIS IN PRIMARY BILIARY CIRRHOSIS (PBC)
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Many hepatic effects of FXR activation are mediated by intestinal FXR receptors, which cause release of FGF19 that acts on liver targets.
“Many of the hepatic effects of FXR activation are mediated by intestinal FXR receptors, resulting in the release of FGF19, which then acts on targets in the liver136–139.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [139]
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The gut microbiome and liver cancer: mechanisms and clinical translation
Yu, L.-X., & Schwabe, R. F. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.72 · Cited by 634 · see citing works
Novel therapeutic targets in primary biliary cirrhosis
Dyson, J. K., Hirschfield, G. M., Adams, D. H., Beuers, U., Mann, D. A., Lindor, K. D., & Jones, D. E. J. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.12 · Cited by 120 · see citing works
Self-citationPrimary biliary cirrhosis: Pathophysiology, clinical presentation and therapy
Purohit, T. (2015) · World Journal of Hepatology · doi:10.4254/wjh.v7.i7.926 · Cited by 118 · see citing works
Nonsteroidal FXR Ligands: Current Status and Clinical Applications
Gege, C., Hambruch, E., Hambruch, N., Kinzel, O., & Kremoser, C. (2019) · Handbook of Experimental Pharmacology · doi:10.1007/164_2019_232 · Cited by 83 · see citing works
Targeting FXR in cholestasis: hype or hope
Fiorucci, S., Distrutti, E., Ricci, P., Giuliano, V., Donini, A., & Baldelli, F. (2014) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.956087 · Cited by 53 · see citing works
Obeticholic acid and budesonide for the treatment of primary biliary cirrhosis
Silveira, M. G., & Lindor, K. D. (2014) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2014.873404 · Cited by 50 · see citing works
Self-citationPrimary biliary cirrhosis and bile acids
Corpechot, C. (2012) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/s2210-7401(12)70016-5 · Cited by 27 · see citing works
Nolan, J., Johnston, I. M., & Walters, J. R. F. (2012) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.12.66 · Cited by 23 · see citing works
Treatment of primary biliary cirrhosis
Poupon, R. Y., & Corpechot, C. (2013) · Expert Opinion on Orphan Drugs · doi:10.1517/21678707.2014.870031
- Authors
- Marschall, H.-U., Luketic, V., Lovgren-Sandblom, A., Benthin, L., Kowdley, K., Hirschfield, G., Mason, A., Lindor, K., Gordon, S., Vincent, C., Chapman, R., Mayo, M., Burroughs, A., Pares, A., Jones, D., Schramm, C., Eliot, L., Hofmann, A. F., & Shapiro, D.
- ORCID
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 56
- Pages
- S377
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W2067620989
- Cited by
- 9
- References
- 0
- Citations by year
- 2019: 1 · 2017: 1 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Hepatology (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Keywords
- obeticholic acid, farnesoid X receptor agonist, FGF19, bile acid synthesis, primary biliary cirrhosis, bile acid synthesis inhibition
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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