Cited by 389Histone Deacetylase Inhibitors ResearchGenomics and Chromatin DynamicsEpigenetics and DNA Methylation

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NuRD and SIN3

Ahringer, Julie·2000·Trends in Genetics

DOI 10.1016/s0168-9525(00)02066-7

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Abstract

Transcription repression mediated through histone deacetylase (HDAC) complexes is widespread, and mechanisms by which HDAC complexes act have been revealed by extensive studies in vitro and in cell culture. However, until recently, little has been known about the developmental roles of histone deacetylation. Mutants now exist for a number of members of the two major HDAC complexes (NuRD and SIN3) and some associated proteins. The emerging picture is that these complexes have specific functions in development, rather than being required for most cellular processes.

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Authors: Ahringer, J.
Affiliations: Wellcome Trust (GB)
Corresponding author: Ahringer, Julie
ORCID: Ahringer, Julie
Venue: Trends in Genetics
Publisher: Elsevier BV
Published: 2000-08
Volume: 16
Issue: 8
Pages: 351-356
ISSN: 0168-9525 (ISSN-L)
DOI: 10.1016/s0168-9525(00)02066-7
OpenAlex: W2027297574
Cited by: 388
References: 63
Citations by year: 2026: 8 · 2025: 5 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 7 · 2019: 8 · 2018: 4 · 2017: 11 · 2016: 8 · 2015: 13 · 2014: 15 · 2013: 16 · 2012: 16
FWCI: 2.42
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust (054523)
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: NuRD complex, histone deacetylase complex, transcriptional repression, histone deacetylation, developmental gene regulation, chromatin regulation
MeSH terms: Animals, Histone Deacetylases, Humans, Models, Biological, Receptors, Cell Surface, Transcription, Genetic, Arabidopsis, ras Proteins, Macromolecular Substances, Mi-2 Nucleosome Remodeling and Deacetylase Complex, Sin3 Histone Deacetylase and Corepressor Complex

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