The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
NuRD and SIN3
Abstract
Transcription repression mediated through histone deacetylase (HDAC) complexes is widespread, and mechanisms by which HDAC complexes act have been revealed by extensive studies in vitro and in cell culture. However, until recently, little has been known about the developmental roles of histone deacetylation. Mutants now exist for a number of members of the two major HDAC complexes (NuRD and SIN3) and some associated proteins. The emerging picture is that these complexes have specific functions in development, rather than being required for most cellular processes.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Generally, when histones are acetylated, chromatin becomes loosely packed euchromatin and gene expression is activated. In contrast, deacetylated histones lead to condensed heterochromatin and repressed gene expression [25].”
From Stem Cell Factor SALL4 Represses the Transcriptions of PTEN and SALL1 through an Epigenetic Repressor Complex (2009) · cites this paper as [25]
In the citing paper
“This is consistent with the fact that both genes encode proteins involved in histone modification and chromatin remodeling [21,23-25,30-33].”
From A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development (2008) · cites this paper as [30]
Citations
Cites
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429
Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
Amir, R. E., Van den Veyver, I. B., Wan, M., Tran, C. Q., Francke, U., & Zoghbi, H. Y. (1999) · Nature Genetics · doi:10.1038/13810 · Cited by 4,990
Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
Jones, P. L., Veenstra, G. J. C., Wade, P. A., Vermaak, D., Kass, S. U., Landsberger, N., Strouboulis, J., & Wolffe, A. P. (1998) · Nature Genetics · doi:10.1038/561 · Cited by 2,791
Hörlein, A., Näär, A. M., Heinzel, T., Torchia, J., Gloss, B. R., Kurokawa, R., Ryan, A. K., Kamei, Y., Söderström, M., Glass, C. K., et al. (1995) · Nature · doi:10.1038/377397a0 · Cited by 2,072
A transcriptional co-repressor that interacts with nuclear hormone receptors
Chen, J. D., & Evans, R. M. (1995) · Nature · doi:10.1038/377454a0 · Cited by 1,794
Retinoblastoma protein recruits histone deacetylase to repress transcription
Brehm, A., Miska, E. A., McCance, D. J., Reid, J. L., Bannister, A. J., & Kouzarides, T. (1998) · Nature · doi:10.1038/35404 · Cited by 1,231
Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase
Nagy, L., Kao, H.-Y., Chakravarti, D., Lin, R. J., Hassig, C. A., Ayer, D. E., Schreiber, S. L., & Evans, R. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80218-4 · Cited by 1,230
A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression
Heinzel, T., Lavinsky, R. M., Mullen, T.-M., Söderström, M., Laherty, C. D., Torchia, J., Yang, W., Brard, G., Ngo, S. D., Davie, J., et al. (1997) · Nature · doi:10.1038/387043a0 · Cited by 1,210
Zhang, Y., Ng, H.-H., Erdjument-Bromage, H., Tempst, P., Bird, A., & Reinberg, D. (1999) · Genes & Development · doi:10.1101/gad.13.15.1924 · Cited by 1,103
Role of the histone deacetylase complex in acute promyelocytic leukaemia
Lin, R. J., Nagy, L., Inoue, S., Shao, W., Miller, W. H., & Evans, R. M. (1998) · Nature · doi:10.1038/35895 · Cited by 1,060
Cited by
Sorted by citations
Items 301–389 of 389
Retinoblastoma binding protein 7 is involved in Kiss1 mRNA upregulation in rodents
Horihata, K., Inoue, N., Uenoyama, Y., Maeda, K., & Tsukamura, H. (2020) · Journal of Reproduction and Development · doi:10.1262/jrd.2019-149 · Cited by 10
Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2
Li, G., Franco, P. J., & Wei, L. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.08.145 · Cited by 9
Montibus, B., Ragheb, R., Diamanti, E., Dunn, S.-J., Reynolds, N., & Hendrich, B. (2023) · Biology Open · doi:10.1242/bio.060101 · Cited by 9
Zhao, Y., Lü, J., Sun, H., Chen, X., & Huang, B. (2007) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-007-9547-x · Cited by 8
Mikoláš, P., Kollárová, J., Šebková, K., Saudek, V., Yilma, P., Kostrouchová, M., Krause, M., Kostrouch, Z., & Kostrouchová, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058462 · Cited by 8
Cai, L., Wang, D., Fisher, A. L., & Wang, Z. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.03.138 · Cited by 8
The human SIN3B corepressor forms a nucleolar complex with leukemia-associated ETO homologues
Dhanda, R. S., Lindberg, S. R., & Olsson, I. (2008) · BMC Molecular Biology · doi:10.1186/1471-2199-9-8 · Cited by 8
Retinoblastoma family of proteins and chromatin epigenetics: a repetitive story in a few LINEs
Montoya-Durango, D. E., & Ramos, K. S. (2011) · BioMolecular Concepts · doi:10.1515/bmc.2011.027 · Cited by 8
Biochemistry of Multiprotein HDAC Complexes
Vaquero, A., Scher, M. B., & Reinberg, D. (2006) · Humana Press eBooks · doi:10.1385/1-59745-024-3:23 · Cited by 7
Wu, Z., Shi, H., Li, Y., Yan, F., Sun, Z., Lin, C., Xu, M., Lin, F., Kou, Y., & Zeng, T. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.00171-23 · Cited by 6
Khoo, B. L., Kumar, P., Lim, C. T., & Thiery, J. P. (2016) · Current cancer research · doi:10.1007/978-1-4939-3363-1_8 · Cited by 6
Wrobel, J. A., Xie, L., Wang, L., Liu, C., Rashid, N. U., Gallagher, K. K., Xiong, Y., Konze, K. D., Jin, J. J., Gatza, M. L., et al. (2019) · iScience · doi:10.1016/j.isci.2019.07.001 · Cited by 6
Pharmacoepigenetics of Histone Deacetylase Inhibitors in Cancer
Garmpis, N., Damaskos, C., Garmpi, A., Valsami, S. I., & Dimitroulis, D. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813939-4.00013-9 · Cited by 5
ZFP932 Suppresses Cellular Hedgehog Response and Patched1 Transcription
Huang, G. J., He, Z., & Ma, L. (2012) · Vitamins and hormones · doi:10.1016/b978-0-12-394622-5.00014-6 · Cited by 5
Epigenetic Regulation of Notch Signaling During Drosophila Development
Wei, C., Phang, C.-W., & Jiao, R. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-34436-8_4 · Cited by 5
Notch1 signaling is irresponsible to the anti-leukemic effect of HDACis in B-ALL Nalm-6 cells
Shao, N., Ma, D., Wang, J., Lu, T., Guo, Y., & Ji, C. (2012) · Annals of Hematology · doi:10.1007/s00277-012-1561-8 · Cited by 5
Meunier, D., & Seiser, C. (2006) · Humana Press eBooks · doi:10.1385/1-59745-024-3:3 · Cited by 5
Histone Modifications and Histone Variants in Pluripotency and Differentiation
Bannister, A. J., Falcão, A. M., & Castelo‐Branco, G. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803395-1.00002-2 · Cited by 4
Multiple Mechanisms of Transcriptional Repression in Eukaryotes
Arnosti, D. N. (2004) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-18932-6_2 · Cited by 4
Epigenetic System: A Pathway to Malignancies and a Therapeutic Target
Nakao, M., Minami, T., Ueda, Y., Sakamoto, Y., & Ichimura, T. (2004) · International Journal of Hematology · doi:10.1532/ijh97.04052 · Cited by 4
Koulle, A., Ogundele, O., Shah, D., Baker, I. M., Lopez, M., Lando, D., Reynolds, N., Ragheb, R., Laue, E. D., & Hendrich, B. (2025) · eLife · doi:10.7554/elife.109280 · Cited by 6
Rincón‐Arano, H., Parkhurst, S. M., & Groudine, M. T. (2013) · Fly · doi:10.4161/fly.24732 · Cited by 3
Ueno, Y., & Springer, P. S. (2011) · PLANT MORPHOLOGY · doi:10.5685/plmorphol.23.71 · Cited by 3
Comprehensive analysis of circular RNAs in nasopharyngeal cancer
Zhu, S., Wang, X., Xie, H., & Liu, L. (2023) · Genes & Genomics · doi:10.1007/s13258-023-01438-x · Cited by 2
Building a Pluripotency Protein Interaction Network for Embryonic Stem Cells
Ng, P. M. L., & Lufki, T. (2011) · InTech eBooks · doi:10.5772/23634 · Cited by 2
Epigenetic-Based Companion Diagnostics
Neste, L. V., Jones, G. R., Criekinge, W. V., & Clark, J. S. (2011) · Personalized Medicine · doi:10.2217/pme.11.70 · Cited by 2
Functional Analysis of Chromodomain Helicase DNA Binding Protein 2(CHD2) mediated Genomic Stability
Rajagopalan, S. (2010) · Cited by 2
RNA-Based dCas9–VP64 System Improves the Viability of Cryopreserved Mammalian Cells
Hu, Y., Li, L., Yin, Y., Huang, H., Uygun, B. E., & Yarmush, M. L. (2018) · Nano LIFE · doi:10.1142/s1793984418500046 · Cited by 2
Zhang, Y. (2006) · reroDoc Digital Library · Cited by 2
Ferrando-Marco, M., del Valle, B. G., Hintze, M., Narunsky, L., Lin, S., Huang, J., Edwards, S., & Barkoulas, M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.23.707389 · Cited by 2
Royce, S. G., Ververis, K., & Karagiannis, T. C. (2012) · ISRN Pulmonology · doi:10.5402/2012/452307 · Cited by 1
Analysis of histone deacetylase families of Arabidopsis thaliana and Oryza sativa
Iype, J. M., Mishra, R., Karthikeyan, S., Gosipatala, S. B., & Muthukaliannan, G. K. (2013) · African Journal of Agricultural Research · doi:10.5897/ajar11.1906 · Cited by 1
Hormonally Regulated Transcription Factors
Bolander, F. F. (2004) · Elsevier eBooks · doi:10.1016/b978-012111232-5/50013-0 · Cited by 1
Enhancement of PRMT6 binding to a novel germline GATA1 mutation associated with congenital anemia
Lu, Y., Zhu, Q., Wang, Y., Luo, M., Huang, J., Liang, Q., Huang, L., Ouyang, J., Li, C., Tang, N., et al. (2024) · Haematologica · doi:10.3324/haematol.2023.284183 · Cited by 1
Koulle, A., Ogundele, O., Shah, D., Baker, I. M., Lopez, M. L. D., Lando, D., Reynolds, N., Ragheb, R., Laue, E. D., & Hendrich, B. (2026) · eLife · doi:10.1101/2025.08.29.672645 · Cited by 1
Utility of Myositis-Specific Autoantibodies for Treatment Selection in Myositis
Casal-Domínguez, M., Pinal‐Fernandez, I., & Mammen, A. L. (2022) · Current Treatment Options in Rheumatology · doi:10.1007/s40674-022-00198-1 · Cited by 1
Reyes, J. C., Brzeski, J., & Jerzmanowski, A. (2007) · Blackwell Publishing Ltd eBooks · doi:10.1002/9780470988886.ch5 · Cited by 1
THE MOLECULAR, CELLULAR, AND GENETIC BASIS OF HEMOGLOBIN DISORDERS
Steinberg, M. H., Forget, B. G., Higgs, D. R., & Weatherall, D. J. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511596582.004 · Cited by 1
Brown, T. A. (2018) · Garland Science eBooks · doi:10.1201/9781315226828-10 · Cited by 1
ABERRANT EPIGENETICS IN THE MOLECULAR PATHOGENESIS OF HUMAN ACUTE MYELOID LEUKEMIA
Scott, S. A. (2005) · University Library - University of Saskatchewan (University of Saskatchewan) · Cited by 1
Xenophontos, M., Reynolds, N., Gharbi, S., Johnstone, E. R., Signolet, J., Floyd, R., Ralser, M., Bornelöv, S., Dietmann, S., Loos, R., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/103192 · Cited by 1
Reyes, J. C., Brzeski, J., & Jerzmanowski, A. (2017) · Annual Plant Reviews online · doi:10.1002/9781119312994.apr0300 · Cited by 1
Koulle, A., Ogundele, O., Shah, D., Baker, I. M., Lopez, M., Reynolds, N., Ragheb, R., Laue, E., & Hendrich, B. (2025) · eLife · doi:10.7554/elife.109280.1 · Cited by 1
Expression of HDAC1 in leukemia cells
Sethi, H. (2012)
Unhavaithaya, Y. (2003) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/yr86-6282
Molecular diversity in the Notch receptor family
Beatus, P. (2001) · Figshare
Control of Gene Expression by Histone Deacetylases
Miki, B. L. A., & Wu, K. (2003) · Springer eBooks · doi:10.1007/978-94-017-2679-5_40
Molecular Mechanisms of the Transcriptional co-activator Mastermind-Like 1
Hansson, M. L. (2010) · Figshare
The epigenetic regulation of RIZ1 in human leukemia
Beaton-Brown, E. L. D. (2008) · University Library - University of Saskatchewan (University of Saskatchewan)
Regulation of YY1, a Multifunctional Transcription Factor
Yao, Y. (2001) · Digital Commons - University of South Florida (University of South Florida)
Deplus, R., & Fuks, F. (2005) · Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles)
Functional characterization of m-Bop, a transcriptional repressor essential for heart development
Sims, R. J. (2002) · Texas ScholarWorks (Texas Digital Library)
Nakayama, J., Ohtani, Y., Shinmyozu, K., Hayakawa, T., Hayakawa, N., Nishibuchi, G., & Shibata, Y. (2014)
A Co-Repressor of Transcription that Interacts with the Adenovirus E1A Protein
Sundqvist, A. (2001)
Regulation of apoptosis by mar binding protein smar1
Sinha, S. (2009) · INFLIBNET
der Steen, T. V. (2012) · NDSU Repository (North Dakota State University)
Probst, A. V. (2004) · edoc (University of Basel) · doi:10.5451/unibas-003660704
Regulation of osteoclast differentiation by transcription factors MITF, PU.1 and EOS.
Hu, R. (2007) · OhioLink ETD Center (Ohio Library and Information Network)
Histone Deacetylases and ASYMMETRIC LEAVES2 Are Involved in the Establishment of Polarity in
Ueno, Y., Watanabe, K., Okada, K., & Machida, Y. (2007)
REPRESSION OF GENE EXPRESSION BY TRANSCRIPTION FACTORS
Latchman, D. S. (2008) · Elsevier eBooks · doi:10.1016/b978-012373983-4.50014-6
Proteins That Modulate DNA Methylation Aberrations in Cancer
Tollefsbol, T. O. (2008) · doi:10.1201/9781420045802-9
Novel mechanisms of transcriptional regulation by leukemia fusion proteins
Gow, C. (2014) · OhioLink ETD Center (Ohio Library and Information Network)
The Role of CtBP in Pituitary Tumorigenesis
Dorman, K. (2010) · TSpace (University of Toronto)
3 Genetic and Epigenetic Considerations in iPSC Technology
Tanaka, Y., & Park, I. (2017) · CRC Press eBooks · doi:10.1201/b21629-3
Repression of Gene Expression by Transcription Factors
Latchman, D. S. (2004) · Elsevier eBooks · doi:10.1016/b978-012437178-1/50012-6
Urnov, F. D., & Wolffe, A. P. (2002) · Elsevier eBooks · doi:10.1016/b978-012174597-4.50005-3
Bhat, J. A., Dar, N. J., Ahmad, M., Mintoo, M. J., Najar, R. A., Capalash, N., Mondhe, D. M., Sharma, S., Shah, B. A., Hamid, A., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-56819/v1
3 Genetic and Epigenetic Considerations in iPSC Technology
Tanaka, Y., & Park, I. (2017) · CRC Press eBooks · doi:10.1201/9781315402185-4
(2004) · Encyclopedic Dictionary of Genetics, Genomics and Proteomics · doi:10.1002/0471684228.egp08697
Proteins That Modulate DNA Methylation Aberrations in Cancer
Phipps, S. M. O., Tollefsbol, T. O., Andrews, L., & Walthall, S. L. (2008) · CRC Press eBooks · doi:10.1201/9781420045802.ch5
(2004) · Encyclopedic Dictionary of Genetics, Genomics and Proteomics · doi:10.1002/0471684228.egp05727
Zhu, C., Chen, C., Gong, X., Li, H., Li, Y., Zhang, B., Zhang, H., & Yuan, W. (2025) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2025.109761
Pharmacoepigenetics of histone deacetylase inhibitors in cancer
Damaskos, C., Garmpis, N., Dimitroulis, D., Garmpi, A., Valsami, S. I., Effraimidou, E. I., & Kouraklis, G. P. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-18722-3.00018-9
Systemic identification and characterization of the conserved core NuRD complex in planarian
Huang, L., Wang, H., Wu, S., Chai, J., Zou, X., Liu, H., Guo, Z., Wang, Y., & Kan, Y. (2025) · Frontiers in Aging · doi:10.3389/fragi.2025.1687668 · Cited by 1
Investigation of SIN-3 Histone Deacetylase Complex in Caenorhabditis elegans
Kontos, M. (2013) · Syracuse University Libraries (Syracuse University)
(2009) · Science-Business eXchange · doi:10.1038/scibx.2009.865
Punga, T. (2003) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Molecular Characterization of the mop2, a Gene Required for Epigenetic Silencing
Cai, Y. (2006) · UA Campus Repository (The University of Arizona)
Koulle, A., Ogundele, O., Shah, D., Baker, I. M., Lopez, M., Reynolds, N., Ragheb, R., Laue, E. D., & Hendrich, B. (2026) · eLife · doi:10.7554/elife.109280.2
Linarès, A. (2011) · theses.fr (ABES) · doi:10.70675/b58d4038z85d2z4a6fza2b6z64e5e5b158c3
ENO1 couples HDAC1 to regulate histone lactylation and gene transcription
Zhai, G., Zhao, F., Wang, Y., Jiang, Z., Li, Y., Fan, Z., Zheng, W., Han, Y., Zhang, J., Zang, Y., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2535245123
Akhtartavan, S., Madanchi, H., Ghorbani, R., Khalafi‐Nezhad, A., Abdullahi, A. M., Shamsi, F., & Heli, H. (2026) · Analytical Cellular Pathology · doi:10.1155/ancp/9606190
Ferrando-Marco, M., Lin, S., del Valle, B. G., Hintze, M., Narunsky, L., Huang, J., Edwards, S., & Barkoulas, M. (2026) · Development · doi:10.1242/dev.205658
Jiang, L., Lin, G., Shi, M., Wu, J., Sun, L., Xu, X., Zhang, Z., Wen, S., Chen, M., Gao, X., et al. (2026) · Physiology and Molecular Biology of Plants · doi:10.1007/s12298-026-01805-4
Buchert, E. M., Fogarty, E. A., Ma, Y., Mehta, S. J. K., McKay, D. J., & Buttitta, L. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.16.752104
Chan, S. C., Gearhart, M. D., Diao, Z., Higgins, L., Markowski, T. W., Shao, A., & Igarashi, P. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.23.759945
Class I Lysine Deacetylases Facilitate Glucocorticoid Receptor-Mediated Transcriptional Activation
Kadiyala, V. (2013) · UA Campus Repository (The University of Arizona)
Metadata
- Authors
- Ahringer, J.
- Affiliations
- Wellcome Trust (GB)
- Corresponding author
- Ahringer, Julie
- ORCID
- Ahringer, Julie
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 2000-08
- Volume
- 16
- Issue
- 8
- Pages
- 351-356
- ISSN
- 0168-9525 (ISSN-L)
- OpenAlex
- W2027297574
- Cited by
- 388
- References
- 63
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 7 · 2019: 8 · 2018: 4 · 2017: 11 · 2016: 8 · 2015: 13 · 2014: 15 · 2013: 16 · 2012: 16
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (054523)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- NuRD complex, histone deacetylase complex, transcriptional repression, histone deacetylation, developmental gene regulation, chromatin regulation
- MeSH terms
- Animals, Histone Deacetylases, Humans, Models, Biological, Receptors, Cell Surface, Transcription, Genetic, Arabidopsis, ras Proteins, Macromolecular Substances, Mi-2 Nucleosome Remodeling and Deacetylase Complex, Sin3 Histone Deacetylase and Corepressor Complex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review