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Up-regulation of D3 dopamine receptor mRNA in the nucleus accumbens of human cocaine fatalities
Open accessAbstract
The effects of chronic cocaine use on D3 receptor mRNA expression in the human nucleus accumbens was assessed by reverse transcription-polymerase chain reaction. D3 receptor/cyclophilin mRNA ratios in the nucleus accumbens were increased 6-fold in cocaine overdose victims as compared to age-matched and drug-free control subjects. This finding demonstrates that chronic cocaine exposure leads to adaptive increases in the expression of D3 receptor mRNA in a critical reward center in brain.
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Cites
Cellular and molecular mechanisms of drug dependence
Koob, G. F., & Bloom, F. E. (1988) · Science · doi:10.1126/science.2903550 · Cited by 2,070
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Genetics of dopamine receptors and drug addiction: a comprehensive review
Foll, B. L., Gallo, A., Strat, Y. L., Lu, L., & Gorwood, P. (2009) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3283242f05 · Cited by 393
Brake, W. G., Zhang, T. Y., Diorio, J., Meaney, M. J., & Gratton, A. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03286.x · Cited by 342
Boileau, I., Payer, D., Chugani, B., Lobo, D., Behzadi, A., Rusjan, P. M., Houle, S., Wilson, A. A., Warsh, J., Kish, S. J., et al. (2013) · Addiction · doi:10.1111/add.12066 · Cited by 190
Unpredictable saccharin reinforcement enhances locomotor responding to amphetamine
Singer, B. F., Scott-Railton, J., & Vezina, P. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.09.003 · Cited by 117
Prenatal nicotine sex-dependently alters adolescent dopamine system development
Dwyer, J. B., Cardenas, A., Franke, R. M., Chen, Y., Bai, Y., Belluzzi, J. D., Lotfipour, S., & Leslie, F. M. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0640-1 · Cited by 30
Metadata
- Authors
- Segal, D. M., Moraes, C. T., & Mash, D. C.
- Venue
- Molecular Brain Research
- Publisher
- Elsevier BV
- Published
- 1997-05
- Volume
- 45
- Issue
- 2
- Pages
- 335-339
- ISSN
- 0169-328X (ISSN-L)
- OpenAlex
- W1963562655
- Cited by
- 161
- References
- 1
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Segal, D. M., Moraes, C. T., & Mash, D. C. (1997). Up-regulation of D3 dopamine receptor mRNA in the nucleus accumbens of human cocaine fatalities. Molecular Brain Research. https://doi.org/10.1016/s0169-328x(97)00025-9
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.