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Cited by 68Alzheimer's disease research and treatmentsDevelopmental Biology and Gene RegulationNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons

Berezovska, O, Frosch, M, McLean, P, Knowles, R, Koo, E, Kang, D, Shen, J, Lu, F.M, Lux, S.E, Tonegawa, S, Hyman, B.T·1999·Molecular Brain Research
DOI 10.1016/s0169-328x(99)00119-9
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Abstract

The normal functional neurobiology of the Alzheimer's disease (AD) related gene presenilin 1 (PS1) is unknown. One clue comes from a genetic screen of Caenorhabditis elegans, which reveals that the presenilin homologue sel-12 facilitates lin-12 function [D. Levitan, I. Greenwald, Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene, Nature 377 (1995) 351-355]. The mammalian homologue of lin-12, Notch1, is a transmembrane receptor that plays an important role in cell fate decisions during development, including neurogenesis, but does not have a known function in fully differentiated cells. To better understand the potential role of Notch1 in mammalian postmitotic neurons and to test the hypothesis that Notch and PS 1 interact, we studied the effect of Notch1 transfection on neurite outgrowth in primary cultures of hippocampal/cortical neurons. We demonstrate that Notch1 inhibits neurite extension, and thus has a function in postmitotic mature neurons in the mammalian CNS. Furthermore, we present evidence demonstrating that there is a functional interaction between PS1 and Notch1 in mammalian neurons, analogous to the sel-12/lin-12 interaction in vulval development in C. elegans [D. Levitan, T. Doyle, D. Brousseau, M. Lee, G. Thinakaran, H. Slunt, S. Sisodia, I. Greenwald, Assessment of normal and mutant human presenilin function in Caenorhabditis elegans, Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 14940-14944; D. Levitan, I.…

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Research works printed but not linked: 36

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Metadata

Authors
Berezovska, O., Frosch, M., McLean, P., Knowles, R., Koo, E., Kang, D., Shen, J., Lu, F. M., Lux, S. E., Tonegawa, S., & Hyman, B. T.
Affiliations
  • Massachusetts General Hospital (US)
  • Brigham and Women's Hospital (US)
  • University of California San Diego (US)
  • Boston Children's Hospital (US)
  • Howard Hughes Medical Institute (US)
Corresponding author
Hyman, B.T
ORCID
Venue
Molecular Brain Research
Publisher
Elsevier BV
Published
1999-06
Volume
69
Issue
2
Pages
273-280
ISSN
0169-328X (ISSN-L)
DOI
10.1016/s0169-328x(99)00119-9
OpenAlex
W2059303812
Cited by
68
References
2
Citations by year
2022: 1 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 5
FWCI
4.66
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Molecular Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ag014744-03)
  • National Institute on Aging (P01AG015379, AG 14744, P01AG15379, P01AG011337, AG11337)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
presenilin 1, Notch1, Alzheimer's disease, neurite outgrowth, postmitotic neurons, hippocampal neurons, cortical neurons, Caenorhabditis elegans, neurogenesis, cell fate determination, Notch signaling, protein-protein interaction
MeSH terms
Alzheimer Disease, Animals, Cells, Cultured, Humans, Membrane Proteins, Mice, Transgenic, Morphogenesis, Neurons, Receptors, Cell Surface, Transcription Factors, Mice, Knockout, Gene Expression Regulation, Developmental, Mice, Receptor, Notch1, Presenilin-1

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