Tonegawa, Susumu

Somatic generation of antibody diversity

Tonegawa, S. (1983) · Nature

T-cell and B-cell ImmunologyMonoclonal and Polyclonal Antibodies Research

Cited by 4,005

The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory.

Tsien, J. Z., Huerta, P. T., & Tonegawa, S. (1996) · Cell

Memory and Neural MechanismsNeuroscience and Neuropharmacology Research

Cited by 1,782

Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice

Silva, A. J., Stevens, C. F., Tonegawa, S., & Wang, Y. (1992) · Science

Neuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Cited by 1,472

Subregion- and Cell Type–Restricted Gene Knockout in Mouse Brain

Tsien, J. Z., Chen, D. F., Gerber, D., Tom, C., Mercer, E. H., Anderson, D. J., Mayford, M., Kandel, E. R., & Tonegawa, S. (1996) · Cell

Animal Genetics and ReproductionCRISPR and Genetic Engineering

Cited by 1,280

BDNF Regulates the Maturation of Inhibition and the Critical Period of Plasticity in Mouse Visual Cortex

Huang, Z. J., Kirkwood, A., Pizzorusso, T., Porciatti, V., Morales, B., Bear, M. F., Maffei, L., & Tonegawa, S. (1999) · Cell

Neuroscience and Neuropharmacology ResearchVisual perception and processing mechanisms

Cited by 1,198

Engrams and circuits crucial for systems consolidation of a memory

Kitamura, T., Ogawa, S. K., Roy, D. S., Okuyama, T., Morrissey, M. D., Smith, L. M., Redondo, R. L., & Tonegawa, S. (2017) · Science

Memory and Neural MechanismsMemory Processes and Influences

Cited by 1,104

Memory engrams: Recalling the past and imagining the future

Josselyn, S. A., & Tonegawa, S. (2020) · Science

Memory and Neural MechanismsMemory Processes and Influences

Cited by 1,087

Heme oxygenase 1 is required for mammalian iron reutilization

Poss, K. D., & Tonegawa, S. (1997) · Proceedings of the National Academy of Sciences

Heme Oxygenase-1 and Carbon MonoxideIron Metabolism and Disorders

Cited by 1,016

Creating a False Memory in the Hippocampus

Ramirez, S., Liu, X., Lin, P.-A., Suh, J., Pignatelli, M., Redondo, R. L., Ryan, T. J., & Tonegawa, S. (2013) · Science

Memory and Neural MechanismsMemory Processes and Influences

Cited by 968

Skeletal and CNS Defects in Presenilin-1-Deficient Mice

Shen, J., Bronson, R. T., Chen, D. F., Xia, W., Selkoe, D. J., & Tonegawa, S. (1997) · Cell

Alzheimer's disease research and treatmentsNeurogenesis and neuroplasticity mechanisms

Cited by 959

Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network

McHugh, T. J., Jones, M. W., Quinn, J. J., Balthasar, N., Coppari, R., Elmquist, J. K., Lowell, B. B., Fanselow, M. S., Wilson, M. A., & Tonegawa, S. (2007) · Science

Memory and Neural MechanismsNeuroscience and Neuropharmacology Research

Cited by 958

Translational Control by MAPK Signaling in Long-Term Synaptic Plasticity and Memory

Kelleher, R. J., Govindarajan, A., Jung, H.-Y., Kang, H., & Tonegawa, S. (2004) · Cell

Memory and Neural MechanismsNeuroscience and Neuropharmacology Research

Cited by 845

Ordered rearrangement of immunoglobulin heavy chain variable region segments

Alt, F. W., Yancopoulos, G. D., Blackwell, T. K., Wood, C., Thomas, E., Boss, M., Coffman, R., Rosenberg, N., Tonegawa, S., & Baltimore, D. (1984) · The EMBO Journal

T-cell and B-cell ImmunologyDNA Repair Mechanisms

Cited by 733

Preplay of future place cell sequences by hippocampal cellular assemblies

Dragoi, G., & Tonegawa, S. (2011) · Nature

Memory and Neural MechanismsSleep and Wakefulness Research

Cited by 716

Preserved Acute Pain and Reduced Neuropathic Pain in Mice Lacking PKCγ

Malmberg, A. B., Chen, C., Tonegawa, S., & Basbaum, A. I. (1997) · Science

Pain Mechanisms and TreatmentsPain Management and Treatment

Cited by 690

Ventral CA1 neurons store social memory

Okuyama, T., Kitamura, T., Roy, D. S., Itohara, S., & Tonegawa, S. (2016) · Science

Memory and Neural MechanismsNeuroscience and Neuropharmacology Research

Cited by 657

NMDA receptors, place cells and hippocampal spatial memory

Nakazawa, K., McHugh, T. J., Wilson, M. A., & Tonegawa, S. (2004) · Nature Reviews Neuroscience

Memory and Neural MechanismsNeuroscience and Neuropharmacology Research

Cited by 619

Impaired Hippocampal Representation of Space in CA1-Specific NMDAR1 Knockout Mice

McHugh, T. J., Blum, K. I., Tsien, J. Z., Tonegawa, S., & Wilson, M. A. (1996) · Cell

Memory and Neural MechanismsNeuroscience and Neuropharmacology Research

Cited by 593

Translational Regulatory Mechanisms in Persistent Forms of Synaptic Plasticity

Kelleher, R. J., Govindarajan, A., & Tonegawa, S. (2004) · Neuron

Neuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Cited by 592

Conjunctive input processing drives feature selectivity in hippocampal CA1 neurons

Bittner, K. C., Grienberger, C., Vaidya, S. P., Milstein, A. D., Macklin, J. J., Suh, J., Tonegawa, S., & Magee, J. C. (2015) · Nature Neuroscience

Memory and Neural MechanismsNeuroscience and Neuropharmacology Research

Cited by 540

Cell type–specific genetic and optogenetic tools reveal hippocampal CA2 circuits

Kohara, K., Pignatelli, M., Rivest, A. J., Jung, H.-Y., Kitamura, T., Suh, J., Frank, D., Kajikawa, K., Mise, N., Obata, Y., et al. (2014) · Nature Neuroscience

Memory and Neural MechanismsNeuroscience and Neuropharmacology Research

Cited by 528

Bidirectional switch of the valence associated with a hippocampal contextual memory engram

Redondo, R. L., Kim, J., Arons, A. L., Ramirez, S., Liu, X., & Tonegawa, S. (2014) · Nature

Memory and Neural MechanismsMemory Processes and Influences

Cited by 512

Forebrain-Specific Calcineurin Knockout Selectively Impairs Bidirectional Synaptic Plasticity and Working/Episodic-like Memory

Zeng, H., Chattarji, S., Barbarosie, M., Rondi-Reig, L., Philpot, B. D., Miyakawa, T., Bear, M. F., & Tonegawa, S. (2001) · Cell

Memory and Neural MechanismsNeuroscience and Neuropharmacology Research

Cited by 498

Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning

Nakashiba, T., Young, J. Z., McHugh, T. J., Buhl, D. L., & Tonegawa, S. (2008) · Science

Memory and Neural MechanismsNeuroscience and Neuropharmacology Research

Cited by 492