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Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

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Chromatin crosstalk in development and disease: lessons from REST

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The emerging field of epigenetics in neurodegeneration and neuroprotection

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The neurogenetics of alternative splicing

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Widespread Disruption of Repressor Element-1 Silencing Transcription Factor/Neuron-Restrictive Silencer Factor Occupancy at Its Target Genes in Huntington's Disease

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The Master Negative Regulator REST/NRSF Controls Adult Neurogenesis by Restraining the Neurogenic Program in Quiescent Stem Cells

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Transcriptional Regulation: Cancer, Neurons and the REST

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Cross-Regulation between an Alternative Splicing Activator and a Transcription Repressor Controls Neurogenesis

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The transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes

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A splice variant of the neuron-restrictive silencer factor repressor is expressed in small cell lung cancer: a potential role in derepression of neuroendocrine genes and a useful clinical marker.

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REST Controls Self-Renewal and Tumorigenic Competence of Human Glioblastoma Cells

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DYRK1A: the double-edged kinase as a protagonist in cell growth and tumorigenesis

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The Transcription Factor REST Is Lost in Aggressive Breast Cancer

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Brain REST/NRSF Is Not Only a Silent Repressor but Also an Active Protector

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Epigenetics and Epilepsy

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Neuron-restrictive Silencer Factor (NRSF) Functions as a Repressor in Neuronal Cells to Regulate the μ Opioid Receptor Gene

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Regulation of the NRSF/REST gene by methylation and CREB affects the cellular phenotype of small-cell lung cancer

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Regulation and role of REST and REST4 variants in modulation of gene expression in in vivo and in vitro in epilepsy models

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Loss of the repressor REST in uterine fibroids promotes aberrant G protein-coupled receptor 10 expression and activates mammalian target of rapamycin pathway

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Regulation of non-coding RNA networks in the nervous system—What's the REST of the story?

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α-Synuclein enhances histone H3 lysine-9 dimethylation and H3K9me2-dependent transcriptional responses

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Neuron-specific alternative splicing of transcriptional machineries: Implications for neurodevelopmental disorders

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Gene expression signatures of neuroendocrine prostate cancer and primary small cell prostatic carcinoma

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Transcriptional Activation of REST by Sp1 in Huntington's Disease Models

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MED19 and MED26 Are Synergistic Functional Targets of the RE1 Silencing Transcription Factor in Epigenetic Silencing of Neuronal Gene Expression

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Defects in the Alternative Splicing-Dependent Regulation of REST Cause Deafness

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Transcription Factors in Cancer: When Alternative Splicing Determines Opposite Cell Fates

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Specificity Protein 1 (Sp1)-dependent Activation of the Synapsin I Gene (SYN1) Is Modulated by RE1-silencing Transcription Factor (REST) and 5′-Cytosine-Phosphoguanine (CpG) Methylation

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Neuronal K + /Cl – co‐transporter (KCC2) transgenes lacking neurone restrictive silencer element recapitulate CNS neurone‐specific expression and developmental up‐regulation of endogenous KCC2 gene

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The Role of Membrane Complement Regulatory Proteins in Cancer Immunotherapy

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Stepwise assembly of functional C‐terminal REST/NRSF transcriptional repressor complexes as a drug target

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More than a Corepressor: The Role of CoREST Proteins in Neurodevelopment

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Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST

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Reduced expression of the neuron restrictive silencer factor permits transcription of glycine receptor α1 subunit in small-cell lung cancer cells

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RNA Splicing Factors SRRM3 and SRRM4 Distinguish Molecular Phenotypes of Castration-Resistant Neuroendocrine Prostate Cancer

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REST-VP16 activates multiple neuronal differentiation genes in human NT2 cells

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Targeting transcription factors for therapeutic benefit

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Neuron-Restrictive Silencer Factor Regulates the N-Methyl-D-aspartate Receptor 2B Subunit Gene in Basal and Ethanol-Induced Gene Expression in Fetal Cortical Neurons

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The regulation of neuronal gene expression by alcohol

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Comparison of REST Cistromes across Human Cell Types Reveals Common and Context-Specific Functions

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The Transcriptional Repressor REST Determines the Cell-Specific Expression of the Human MAPK8IP1 Gene Encoding IB1 (JIP-1)

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Expression and functions of the repressor element 1 (RE‐1)‐silencing transcription factor (REST) in breast cancer

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Molecular and Cellular Mechanisms of Ischemia-Induced Neuronal Death

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REST Is Not Resting: REST/NRSF in Health and Disease

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Regulation of the neuronal transcription factor NPAS4 by REST and microRNAs

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TRF2-Mediated Stabilization of hREST4 Is Critical for the Differentiation and Maintenance of Neural Progenitors

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The role of the RE1 element in activation of the NR1 promoter during neuronal differentiation

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Diverse Functions of Multiple Bdnf Transcripts Driven by Distinct Bdnf Promoters

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Characterization of the nuclear targeting signal of REST/NRSF

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How Much REST Is Enough?

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NRSF: an Angel or a Devil in Neurogenesis and Neurological Diseases

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RE-1 silencing transcription factor-4 (REST4) is neither a transcriptional repressor nor a de-repressor

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Extensive Alternative Splicing of the Repressor Element Silencing Transcription Factor Linked to Cancer

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An expression based REST signature predicts patient survival and therapeutic response for glioblastoma multiforme

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Relaxation of glycine receptor and onconeural gene transcription control in NRSF deficient small cell lung cancer cell lines

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NRSF and Its Epigenetic Effectors: New Treatments for Neurological Disease

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IB1/JIP-1 controls JNK activation and increased during prostatic LNCaP cells neuroendocrine differentiation

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The Importance of REST for Development and Function of Beta Cells

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Expression Patterns of Mouse Repressor Element-1 Silencing Transcription Factor 4 (REST4) and its Possible Function in Neuroblastoma

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Mechanical stimulation induces preprotachykinin gene expression in osteoarthritic chondrocytes which is correlated with modulation of the transcription factor neuron restrictive silence factor

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Identification of a neurorestrictive suppressor element (NRSE) in the human μ-opioid receptor gene

Andria, M. L., & Simon, E. J. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00124-3 · Cited by 25 · see citing works

Molecular mechanisms and potential prognostic effects of REST and REST4 in glioma

Li, C., Wang, Z., Tang, X., Zeng, L., Fan, X., & Li, Z. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7071 · Cited by 23 · see citing works

Alternative REST Splicing Underappreciated

Chen, G., & Miller, G. M. (2018) · eNeuro · doi:10.1523/eneuro.0034-18.2018 · Cited by 24 · see citing works

In Vitro Ischemia Triggers a Transcriptional Response to Down-Regulate Synaptic Proteins in Hippocampal Neurons

Fernandes, J., Vieira, M. M., Carreto, L. C., Santos, M. A. S., Duarte, C. B., Carvalho, A. L., & Santos, A. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099958 · Cited by 23 · see citing works

NRSF/REST regulates the mTOR signaling pathway in oral cancer cells

Cho, E., Moon, S., Park, B. R., Kim, D. K., LEE, B.-K., & Kim, C. S. (2014) · Oncology Reports · doi:10.3892/or.2014.3675 · Cited by 23 · see citing works

Regulation of gene expression during early neuronal differentiation: evidence for patterns conserved across neuron populations and vertebrate classes

Ernsberger, U. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1367-y · Cited by 22 · see citing works

Navigating the Global Protein–Protein Interaction Landscape Using iRefWeb

Turinsky, A. L., Razick, S., Turner, B., Donaldson, I. M., & Wodak, S. J. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-691-7_22 · Cited by 22 · see citing works

Cell-type non-selective transcription of mouse and human genes encoding neural-restrictive silencer factor

Kojima, T., Murai, K., Naruse, Y., Takahashi, N., & Mori, N. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00107-3 · Cited by 21 · see citing works

Neural restrictive silencer factor and choline acetyltransferase expression in cerebral tissue of Alzheimer's Disease patients: a pilot study

González-Castañeda, R. E., Sánchez-González, V., Flores-Soto, M. E., Vázquez–Camacho, G., Macías-Islas, M. Á., & Ortiz, G. G. (2013) · Genetics and Molecular Biology · doi:10.1590/s1415-47572013000100005 · Cited by 21 · see citing works

The NRSF/REST transcription factor in hallmarks of cancer: From molecular mechanisms to clinical relevance

Arizmendi-Izazaga, A., Martínez-Baltazar, R., Liborio-Bautista, A., Olea‐Flores, M., Ortiz‐Ortiz, J., & Navarro‐Tito, N. (2022) · Biochimie · doi:10.1016/j.biochi.2022.10.012 · Cited by 20 · see citing works

Comparative study of gene expression of cholinergic system-related molecules in the human spinal cord and term placenta

Oda, Y., Muroishi, Y., Misawa, H., & Suzuki, S. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.06.002 · Cited by 19 · see citing works

EST analysis of mRNAs expressed in neurula of Chinese amphioxus

Mou, C., Zhang, S., Lin, J., Yang, W., Wu, W., Wei, J., Wu, X., Du, J., Fu, Z., Ye, L., et al. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02582-2 · Cited by 19 · see citing works

Regulation of mGluR1 expression in human melanocytes and melanoma cells

Lee, H. J., Wall, B., Wangari‐Talbot, J., & Chen, S. (2012) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2012.06.005 · Cited by 18 · see citing works

Deletion of RE1‐silencing transcription factor in striatal astrocytes exacerbates manganese‐induced neurotoxicity in mice

Pajarillo, E. A. B., Demayo, M., Digman, A., Nyarko‐Danquah, I., Son, D., Aschner, M., & Lee, E.-S. (2022) · Glia · doi:10.1002/glia.24226 · Cited by 17 · see citing works

Repressor element 1 silencing transcription factor /neuron-restrictive silencing factor (REST/NRSF) in social stress and depression

Soga, T., Nakajima, S., Kawaguchi, M., & Parhar, I. S. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110053 · Cited by 19 · see citing works

Yin yang 1 directly regulates the transcription of RE‐1 silencing transcription factor

Jiang, L., Yao, M., Shi, J., Shen, P., Niu, G., & Fei, J. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21595 · Cited by 17 · see citing works

Whole-genome functional characterization of RE1 silencers using a modified massively parallel reporter assay

Mouri, K., Dewey, H. B., Castro, R., Berenzy, D., Kales, S., & Tewhey, R. (2022) · Cell Genomics · doi:10.1016/j.xgen.2022.100234 · Cited by 16 · see citing works

Stem Cells Have Different Needs for REST

Hermanson, O. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060271 · Cited by 16 · see citing works

Expression of the repressor element‐1 silencing transcription factor (REST) is influenced by insulin‐like growth factor‐I in differentiating human neuroblastoma cells

Toro, R. D., Baiula, M., & Spampinato, S. M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03828.x · Cited by 16 · see citing works

REST upregulates gremlin to modulate diffuse intrinsic pontine glioma vasculature

Shaik, S., Kennis, B. A., Maegawa, S., Schadler, K., Yanwen, Y., Callegari, K., Lulla, R. R., Goldman, S., Nazarian, J., Rajaram, V., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.23750 · Cited by 15 · see citing works

Induction of the RNA Regulator LIN28A Is Required for the Growth and Pathogenesis of RESTless Breast Tumors

Gunsalus, K. T. W., Wagoner, M. P., Meyer, K., Potter, W. B., Schoenike, B. A., Kim, S. Y., Alexander, C. M., Friedl, A., & Roopra, A. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-1639 · Cited by 15 · see citing works

Post-transcriptional regulation of the transcriptional apparatus in neuronal development

Nazim, M. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1483901 · Cited by 11 · see citing works

Genetic ablation of a candidate tumor suppressor gene, Rest, does not promote mouse colon carcinogenesis

Hatano, Y., Yamada, Y., Hata, K., Phutthaphadoong, S., Aoki, H., & Hara, A. (2011) · Cancer Science · doi:10.1111/j.1349-7006.2011.02006.x · Cited by 12 · see citing works

Non-coding RNAs derived from an alternatively spliced REST transcript (REST-003) regulate breast cancer invasiveness

Lee, N. S., Evgrafov, O. V., Souaiaia, T., Bonyad, A., Herstein, J. S., Lee, J. Y., Kim, J., Ning, Y., Sixto, M., Weitz, A. C., et al. (2015) · Scientific Reports · doi:10.1038/srep11207 · Cited by 12 · see citing works

The Joint Association of REST and NFKB1 Polymorphisms on the Risk of Colorectal Cancer

Yu, Y., Liu, H., Jin, M., Zhang, M., Pan, Y., Zhang, S., Li, Q., & Chen, K. (2012) · Annals of Human Genetics · doi:10.1111/j.1469-1809.2012.00709.x · Cited by 12 · see citing works

Role of NRSF/REST in the molecular mechanisms regulating neural-specific expression of trkC/neurotrophin-3 receptor gene

Nakatani, T., Ueno, S., Mori, N., & Matsuoka, I. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.12.019 · Cited by 12 · see citing works

Mutation and copy number analysis of LNX1 and Numbl in nervous system tumors

Blom, T., Roselli, A., Tanner, M., & Nupponen, N. N. (2008) · Cancer Genetics and Cytogenetics · doi:10.1016/j.cancergencyto.2008.07.003 · Cited by 12 · see citing works

NRSF/REST confers transcriptional repression of the GPR10 gene via a putative NRSE/RE‐1 located in the 5′ promoter region

Kemp, D. M., Lin, J. C., Ubeda, M., & Habener, J. F. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03502-0 · Cited by 12 · see citing works

Mechanisms of aneuploidy and its suppression by tumour suppressor proteins

Thoma, C. R., Toso, A., Meraldi, P., & Krek, W. (2011) · Swiss Medical Weekly · doi:10.4414/smw.2011.13170 · Cited by 11 · see citing works

Binding of hnRNP H and U2AF65 to Respective G-codes and a Poly-Uridine Tract Collaborate in the N50-5'ss Selection of the REST N Exon in H69 Cells

Ortuño‐Pineda, C., Galindo-Rosales, J. M., Calderón-Salinas, J. V., Villegas‐Sepúlveda, N., Cárdenas, O. S., Nova-Ocampo, M. D., & Valdés, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040315 · Cited by 11 · see citing works

Expression of REST4 in human gliomas in vivo and influence of pioglitazone on REST in vitro

Ren, H., Gao, Z., Wu, N., Zeng, L., Tang, X., Chen, X., Liu, Z., Zhang, W., Wang, L., & Li, Z. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.05.058 · Cited by 11 · see citing works

An 840 kb distant upstream enhancer is a crucial regulator of catecholamine‐dependent expression of the Bdnf gene in astrocytes

Avarlaid, A., Esvald, E., Koppel, I., Parkman, A., Zhuravskaya, A., Makeyev, E. V., Tuvikene, J., & Timmusk, T. (2023) · Glia · doi:10.1002/glia.24463 · Cited by 10 · see citing works

In PC12 Cells, Expression of Neurosecretion and Neurite Outgrowth are Governed by the Transcription Repressor REST/NRSF

D’Alessandro, R., & Meldolesi, J. (2010) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-010-9602-0 · Cited by 10 · see citing works

Malignant rhabdoid tumor shows a unique neural differentiation as distinct from neuroblastoma

Higashino, K., Narita, T., Taga, T., Ohta, S., & Takeuchi, Y. (2003) · Cancer Science · doi:10.1111/j.1349-7006.2003.tb01349.x · Cited by 10 · see citing works

Epigenetics, Nervous System Tumors, and Cancer Stem Cells

Qureshi, I., & Mehler, M. F. (2011) · Cancers · doi:10.3390/cancers3033525 · Cited by 9 · see citing works

REST mRNA expression in normal and regenerating avian auditory epithelium

Roberson, D. W., Alosi, J. A., Mercola, M. A., & Cotanche, D. A. (2002) · Hearing Research · doi:10.1016/s0378-5955(02)00512-9 · Cited by 9 · see citing works

A Monoallelic Variant in REST Is Associated with Non-Syndromic Autosomal Dominant Hearing Impairment in a South African Family

Manyisa, N. R., Schrauwen, I., Rios, L. A. D. S., Mowla, S., Tekendo‐Ngongang, C., Popel, K., Esoh, K. K., Bharadwaj, T., Nouel‐Saied, L. M., Acharya, A., et al. (2021) · Genes · doi:10.3390/genes12111765 · Cited by 8 · see citing works

TAF4 Controls Differentiation of Human Neural Progenitor Cells Through hTAF4-TAFH Activity

Kazantseva, J., Tints, K., Neuman, T., & Palm, K. (2014) · Journal of Molecular Neuroscience · doi:10.1007/s12031-014-0295-6 · Cited by 8 · see citing works

Assignment of the REST Gene to 4q12 by Fluorescencein SituHybridization

Cowan, J. M., Powers, J. F., & Tischler, A. S. (1996) · Genomics · doi:10.1006/geno.1996.0281 · Cited by 3 · see citing works

Neuronal Expression of Zinc Finger Transcription Factor REST/NRSF/XBR Gene

Palm, K., Belluardo, N., METSIS, M. L., & Timmusk, T. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-04-01280.1998 · Cited by 372 · see citing works

Transcriptional regulation of the neuron-restrictive silencer factor

Mistry, M. (2001) · UCL Discovery (University College London)

Neuronal expression of zinc finger transcription factor REST/NRSF/XBR

Palm, K., Belluardo, N., Metsis, M., & Timmusk, T. (1998)

NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis

Chen, Z., Paquette, A. J., & Anderson, D. J. (1998) · Nature Genetics · doi:10.1038/2431 · Cited by 461 · see citing works