Widespread Disruption of Repressor Element-1 Silencing Transcription Factor/Neuron-Restrictive Silencer Factor Occupancy at Its Target Genes in Huntington's Disease
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REST is mislocalized in brains of patients with Huntington's disease, with increased nuclear localization and occupancy at RE1 sites compared to healthy controls.
“The transcriptional repressor REST is mislocalized in brains of patients with HD, with increased nuclear localization and occupancy at RE1 sites compared to healthy controls (Zuccato et al., 2003 ; Zuccato et al., 2007).”
From The Bifunctional microRNA miR-9/miR-9* Regulates REST and CoREST and Is Downregulated in Huntington's Disease (2008) · cites this paper as Zuccato et al., 2007
One putative mechanism underlying the transcriptional changes in Huntington's disease is aberrant cellular distribution of the transcriptional repressor REST.
“One putative mechanism underlying the transcriptional changes is aberrant cellular distribution of the transcriptional repressor RE1-silencing transcription factor (REST, also known as neuronal restrictive silencing factor, NRSF) (Lunyak et al., 2002; Zuccato et al., 2003 ; Zuccato et al., 2007).”
From The Bifunctional microRNA miR-9/miR-9* Regulates REST and CoREST and Is Downregulated in Huntington's Disease (2008) · cites this paper as Zuccato et al., 2007
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MACDONALD, M. (1993) · Cell · doi:10.1016/0092-8674(93)90585-e · Cited by 8,366 · see citing works
Self-citationPalm, K., Metsis, M., & Timmusk, T. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00196-5 · Cited by 144 · see citing works
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- Van Raamsdonk JM, Pearson J, Rogers DA, Bissada N, Vogl AW, Hayden MR, Leavitt BR (2005) Loss of wild-type huntingtin influences motor dys- function and survival in the YAC128 mouse model of Huntington disease. Hum Mol Genet 14:1379 -1392.
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Lim, J., Crespo-Barreto, J., Jafar-Nejad, P., Bowman, A. B., Richman, R., Hill, D. E., Orr, H. T., & Zoghbi, H. Y. (2008) · Nature · doi:10.1038/nature06731 · Cited by 311 · see citing works
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Chen, K.-W., & Chen, L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030571 · Cited by 75 · see citing works
Mutant Huntingtin Causes a Selective Decrease in the Expression of Synaptic Vesicle Protein 2C
Peng, C., Zhu, G., Liu, X., & Li, H. (2018) · Neuroscience Bulletin · doi:10.1007/s12264-018-0230-x · Cited by 16 · see citing works
- Authors
- Zuccato, C., Belyaev, N., Conforti, P., Ooi, L., Tartari, M., Papadimou, E., MacDonald, M., Fossale, E., Zeitlin, S., Buckley, N., & Cattaneo, E.
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-06-27
- Volume
- 27
- Issue
- 26
- Pages
- 6972-6983
- ISSN
- 0270-6474
- 1529-2401
- Cited by
- 239
- References
- 2
- Language
- en
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