Gene expression of peroxisomal β-oxidation enzymes in rat brain
Abstract
Despite increasing insight into peroxisomal beta-oxidation, it is still not clear which enzymes catalyze very-long-chain fatty acid degradation. Using the northern blot and RT-PCR techniques, a brain-specific expression is demonstrated for acyl-CoA oxidase 3II mRNA, thiolase-A and trans2,3enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase multifunctional enzyme type 2.
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In the murine brain, mRNA levels of peroxisomal β-oxidation enzymes (ACOX1, DBP, ACAA1a), ABC transporters ABCD2 and ABCD3, and ether phospholipid biosynthesis enzymes increased after birth, reached a maximum during the first weeks and then declined.
“In the murine brain, the mRNA levels of the peroxisomal β-oxidation enzymes (ACOX1, DBP, ACAA1a), the ABC transporters ABCD2 and ABCD3, and the enzymes involved in ether phospholipid biosynthesis increased after birth, reached a maximum during the first weeks and then declined.”
From Peroxisomes in brain development and function (2016) · cites this paper as [26]
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Peroxisomes in brain development and function
Berger, J., Dorninger, F., Forss-Petter, S., & Kunze, M. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.12.005 · Cited by 194 · see citing works
- Authors
- Knoll, A., Sargueil, F., Salles, J., Cassagne, C., & Garbay, B.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Venue
- Molecular Brain Research
- Publisher
- Elsevier BV
- Published
- 1999-12
- Volume
- 74
- Issue
- 1-2
- Pages
- 217-220
- ISSN
- 0169-328X (ISSN-L)
- OpenAlex
- W1983488487
- Cited by
- 9
- References
- 20
- Citations by year
- 2015: 1
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Brain Research (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- peroxisomal beta-oxidation, gene expression, brain, rats
- MeSH terms
- Acetyl-CoA C-Acetyltransferase, Animals, Brain, Carrier Proteins, Enoyl-CoA Hydratase, Enzymes, Hydro-Lyases, Multienzyme Complexes, Oxidation-Reduction, Oxidoreductases, RNA, Messenger, Tissue Distribution, 17-Hydroxysteroid Dehydrogenases, 3-Hydroxyacyl CoA Dehydrogenases, Blotting, Northern, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Developmental, Peroxisomes, Acyl-CoA Oxidase, Rats, Peroxisomal Multifunctional Protein-2
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