Cited by 399biodegradable polymer synthesis and propertiesAdvanced Drug Delivery SystemsHydrogels: synthesis, properties, applications

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Polyanhydrides: an overview

Kumar, Neeraj, Langer, Robert S, Domb, Abraham J·2002·Advanced Drug Delivery Reviews

DOI 10.1016/s0169-409x(02)00050-9

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Abstract

Polyanhydrides have been considered to be useful biomaterials as carriers of drugs to various organs of the human body such as brain, bone, blood vessels, and eyes. They can be prepared easily from available, low cost resources and can be manipulated to meet desirable characteristics. Polyanhydrides are biocompatible and degrade in vivo into non-toxic diacid counterparts that are eliminated from the body as metabolites. Owing to their usefulness, this review focuses on the development, synthesis methods, structures and characterization of polyanhydrides, which will provide an overview for the researchers in the field. Their in vitro and in vivo degradability, toxicity, biocompatibility and applications are discussed in the subsequent chapters of this special issue on polyanhydrides and poly(ortho esters).

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Authors: Kumar, N., Langer, R. S., & Domb, A. J.
Affiliations: Hebrew University of Jerusalem (IL)
Corresponding author: Domb, Abraham J
ORCID: Kumar, Neeraj
Domb, Abraham J
Venue: Advanced Drug Delivery Reviews
Publisher: Elsevier BV
Published: 2002-10
Volume: 54
Issue: 7
Pages: 889-910
ISSN: 0169-409X (ISSN-L)
DOI: 10.1016/s0169-409x(02)00050-9
OpenAlex: W2124696441
Cited by: 394
References: 108
Citations by year: 2026: 7 · 2025: 6 · 2024: 9 · 2023: 15 · 2022: 21 · 2021: 14 · 2020: 19 · 2019: 13 · 2018: 18 · 2017: 18 · 2016: 21 · 2015: 26 · 2014: 22 · 2013: 21 · 2012: 27
FWCI: 0.87
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Advanced Drug Delivery Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Keywords: polyanhydrides, biodegradable polymers, drug delivery, biocompatibility, in vivo degradation, toxicity, polymer synthesis, poly(ortho esters), biomaterials
MeSH terms: Anhydrides, Animals, Drug Carriers, Humans, Polymers, Drug Delivery Systems

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