Cited by 399biodegradable polymer synthesis and propertiesAdvanced Drug Delivery SystemsHydrogels: synthesis, properties, applications

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Polyanhydrides: an overview

Kumar, Neeraj, Langer, Robert S, Domb, Abraham J·2002·Advanced Drug Delivery Reviews

DOI 10.1016/s0169-409x(02)00050-9

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Abstract

Polyanhydrides have been considered to be useful biomaterials as carriers of drugs to various organs of the human body such as brain, bone, blood vessels, and eyes. They can be prepared easily from available, low cost resources and can be manipulated to meet desirable characteristics. Polyanhydrides are biocompatible and degrade in vivo into non-toxic diacid counterparts that are eliminated from the body as metabolites. Owing to their usefulness, this review focuses on the development, synthesis methods, structures and characterization of polyanhydrides, which will provide an overview for the researchers in the field. Their in vitro and in vivo degradability, toxicity, biocompatibility and applications are discussed in the subsequent chapters of this special issue on polyanhydrides and poly(ortho esters).

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Encyclopedia of polymer science and technology
(2003) · Choice Reviews Online · doi:10.5860/choice.41-0674 · Cited by 5,100
Polymeric systems for controlled drug release
Uhrich, K. E., Cannizzaro, S. M., Langer, R. S., & Shakesheff, K. M. (1999) · Chemical Reviews · doi:10.1021/cr940351u · Cited by 2,633
Self-citation
Size matters: Molecular weight affects the efficiency of poly(ethylenimine) as a gene delivery vehicle
Godbey, W. T., Wu, K. K., & Mikos, A. G. (1999) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(19990605)45:3 · Cited by 833
Self-citation
The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres
Gref, R., Domb, A. J., Quellec, P., Blunk, T., Müller, R. H., Verbavatz, J., & Langer, R. (1995) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(95)00026-4 · Cited by 820
Self-citation
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Brem, H., Mahaley, M. S., Vick, N. A., Black, K. L., Schold, S. C., Burger, P. C., Friedman, A. H., Ciric, I. S., Eller, T. W., Cozzens, J. W., et al. (1991) · Journal of neurosurgery · doi:10.3171/jns.1991.74.3.0441 · Cited by 487
Double-walled polymer microspheres for controlled drug release
Pekarek, K. J., Jacob, J. S., & Mathiowitz, E. (1994) · Nature · doi:10.1038/367258a0 · Cited by 280
Enzymatic polymerization: A new method of polymer synthesis
Kobayashi, S. (1999) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/(sici)1099-0518(19990815)37:16 · Cited by 270
Self-citation
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Fujiki, M. (2001) · Macromolecular Rapid Communications · doi:10.1002/1521-3927(20010501)22:8 · Cited by 268
Synthesis and Properties of Poly(acrylic acid)/Mica Superabsorbent Nanocomposite
Lin, J., Wu, J., Yang, Z., & Pu, M. (2001) · Macromolecular Rapid Communications · doi:10.1002/1521-3927(20010301)22:6 · Cited by 266
Bioerodible polyanhydrides as drug‐carrier matrices. II. Biocompatibility and chemical reactivity
Leong, K. W., D'Amore, P. A., Marletta, M. A., & Langer, R. (1986) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820200106 · Cited by 261
Self-citation

Show all 108 references

Research works printed but not linked: 14

Chasin, 1988, Polyanhydrides for controlled drug delivery, Biopharm. Manuf., 1, 33
Mader, 1995, Characterization of microstructures in drug delivery systems by EPR spectroscopy, Proc. Int. Symp. Controlled Release Bioact. Mater., 22, 780
Yoda, 1963, Synthesis of poly(anhydrides). Crystalline and high melting poly(amide) poly(anhydrides) of methylene bis(p-carboxyphenyl) amide, J. Polym. Sci., Part A, 1, 1323
Chasin, 1990, Polyanhydrides as drug delivery systems, Drugs Pharm. Sci., 45, 43
Linhardt, 1983, Bioerodable polyanhydrides for controlled drug delivery, Polym. Prepr., 24, 47
A.J. Domb, O. Elmalak, V.R. Shastri, Z. Ta-Shma, D.M. Masters, I. Ringel, D. Teomim, R. Langer, Polyanhydrides, in: A.J. Domb, J. Kost, D.M. Wiseman (Eds.), Handbook of Biodegradable Polymers, Harwood, London, 1997, pp. 135–159.
Leong, 1984, Bioerodible polyanhydrides as a drug carrier matrix, Polym. Prepr., 25, 201
A.J. Domb, S. Amselem, R. Langer, M. Maniar, Polyanhydrides as carriers of drugs, in: S. Shalaby (Ed.), Designed to Degrade Biomedical Polymers, Hanser, Munich, 1994, pp. 69–96.
Davies, 1991, The analysis of the surface chemical-structure of biomedical aliphatic polyanhydrides using XPS and TOF-SIMS, J. Appl. Polym. Sci., 42, 1597, 10.1002/app.1991.070420613 · DOI
Shakesheff, 1995, The study of the surface degradation of polymer blends using SIMS, XPS, SPR and AFM, Polym. Prepr., 36, 71
A.G. Shard, K.M. Shakesheff, C.J. Roberts, S.J.B. Tendler, M.C. Davies, Surface characterization of bioerodible polymers using XPS, SIMS, and AFM, in: A.J. Domb, J. Kost, D.M. Wiseman (Eds.), Handbook of Biodegradable Polymers, Harwood, London, 1997, pp. 135–159.
A.J. Domb, S. Amselem, Antibiotic delivery systems for the treatment of chronic bone infections, in: A.J. Domb (Ed.), Polymeric Site-Specific Pharmacotherapy, Wiley & Sons, Chichester, 1994, pp. 243–265.
Carraher, 1984, Synthesis and structural characterization of phosphorus-containing aliphatic polyanhydrides, Polym. Prepr., 25, 31
V.R. Shastri, P.P. Hildgen, R. Langer, Y. Najajrah, I. Ringel, A.J. Domb, Other polyesters, in: A.J. Domb, J. Kost, D.M. Wiseman (Eds.), Handbook of Biodebradable Polymers, Harwood, London, 1997, pp. 135–159.

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Authors: Kumar, N., Langer, R. S., & Domb, A. J.
Affiliations: Hebrew University of Jerusalem (IL)
Corresponding author: Domb, Abraham J
ORCID: Kumar, Neeraj
Domb, Abraham J
Venue: Advanced Drug Delivery Reviews
Publisher: Elsevier BV
Published: 2002-10
Volume: 54
Issue: 7
Pages: 889-910
ISSN: 0169-409X (ISSN-L)
DOI: 10.1016/s0169-409x(02)00050-9
OpenAlex: W2124696441
Cited by: 394
References: 108
Citations by year: 2026: 7 · 2025: 6 · 2024: 9 · 2023: 15 · 2022: 21 · 2021: 14 · 2020: 19 · 2019: 13 · 2018: 18 · 2017: 18 · 2016: 21 · 2015: 26 · 2014: 22 · 2013: 21 · 2012: 27
FWCI: 0.87
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Advanced Drug Delivery Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Keywords: polyanhydrides, biodegradable polymers, drug delivery, biocompatibility, in vivo degradation, toxicity, polymer synthesis, poly(ortho esters), biomaterials
MeSH terms: Anhydrides, Animals, Drug Carriers, Humans, Polymers, Drug Delivery Systems

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