The DOI matches its Crossref record; 246 of the 255 references it cites were found in a registry or an index.
Nasal mucociliary clearance as a factor in nasal drug delivery
Abstract
The nasal mucociliary clearance system transports the mucus layer that covers the nasal epithelium towards the nasopharynx by ciliary beating. Its function is to protect the respiratory system from damage by inhaled substances. Impairment of nasal mucociliary clearance can result in diseases of the upper airways. Therefore, it is important to study the effects of drugs and drug excipients on nasal mucociliary clearance. A large number of methods are used to assess mucociliary clearance. These methods study the effects of drug and excipients on the mucociliary system in vitro or in vivo in animals and humans. In some cases, the results of different in vitro and in vivo measurements do not correlate well. In vitro methods, especially ciliary beat frequency measurements, have been demonstrated to be valuable tools for toxicity screening. However, in vivo studies are essential to confirm the safety of nasal drug formulations. Nasal mucociliary clearance also has implications for nasal drug absorption. Drugs are cleared rapidly from the nasal cavity after intranasal administration, resulting in fast systemic drug absorption. Several approaches are discussed to increase the residence time of drug formulations in the nasal cavity, resulting in improved nasal drug absorption. However, more experimental evidence is needed to support the conclusion that this improved absorption is caused by a longer residence time of the nasal drug formulation.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Samples taken from 30 minutes onwards, however, cannot reflect spiking, as substances that are not absorbed across the nasal membrane are transported to the back of the throat, and then swallowed within 15 minutes [14].”
From Salivary oxytocin concentrations in males following intranasal administration of oxytocin: a double-blind, cross-over study (2015) · cites this paper as [14]
In the citing paper
“Hence, taking saliva samples at 15 minutes creates the risk of collecting saliva that is ‘spiked’ with IN-OT (indeed this may be why other saliva studies have chosen 30 minutes as their first measurement, as this allows almost double the length of time of average mucociliary transport [14]).”
From Salivary oxytocin concentrations in males following intranasal administration of oxytocin: a double-blind, cross-over study (2015) · cites this paper as [14]
In the citing paper
“This process of clearing substances from the nasal cavity to the back of the throat, called mucociliary transport, takes 12–15 minutes in healthy individuals [14].”
From Salivary oxytocin concentrations in males following intranasal administration of oxytocin: a double-blind, cross-over study (2015) · cites this paper as [14]
Citations
Cites
The Lung: Scientific Foundations
(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-115-6-503_2 · Cited by 1,183
Mucociliary Clearance in the Airways
Wanner, A., Salathe, M. A., & O’Riordan, T. G. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.154.6.8970383 · Cited by 738
Adenosine Triphosphate-Induced Sliding of Tubules in Trypsin-Treated Flagella of Sea-Urchin Sperm
Summers, K. E., & Gibbons, I. R. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.12.3092 · Cited by 700
Chitosan as a Novel Nasal Delivery System for Peptide Drugs
Illum, L., Farraj, N. F., & Davis, S. S. (1994) · Pharmaceutical Research · doi:10.1023/a:1018901302450 · Cited by 630
The Propulsion of Mucus by Cilia
Sleigh, M. A., Blake, J. R., & Liron, N. (1988) · American Review of Respiratory Disease · doi:10.1164/ajrccm/137.3.726 · Cited by 580
Satir, P. (1968) · The Journal of Cell Biology · doi:10.1083/jcb.39.1.77 · Cited by 556
Ciliary activity of cultured rabbit tracheal epithelium: beat pattern and metachrony
Sanderson, M. J., & Sleigh, M. A. (1981) · Journal of Cell Science · doi:10.1242/jcs.47.1.331 · Cited by 358
Clinical aspects of mucociliary transport.
Wanner, A. (1977) · PubMed · doi:10.1164/arrd.1977.116.1.73 · Cited by 356
McMartin, C., Hutchinson, L. E. F., Hyde, R. J., & Peters, G. E. (1987) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600760709 · Cited by 349
Goblet Cells Secretion And Mucogenesis
Verdugo, P. (1990) · Annual Review of Physiology · doi:10.1146/annurev.ph.52.030190.001105 · Cited by 298
Research works printed but not linked: 10
- Lansley, 1990, Changes in the duration of the effective, recovery and rest phases of the ciliary beat cycle induced by intracellular cAMP and Ca2+, J. Cell Biol., 111, 170a
- Sanderson, 1993, Measurement of the temperospatial dynamics of intercellular calcium signalling with digital fluorescence microscopy, Am. Lab., 25, 29
- Coles, 1983, Effect of topical nasal medications on human nasal ciliary function, Eur. J. Respir. Dis., 126, 121
- Su, 1994, Surface–response study of the effect of pH and tonicity on ciliary activity, STP Pharma. Sci., 4, 82
- King, 1974, On the transport of mucus and its rheological simulants in ciliated system, Am. Rev. Respir. Dis., 110, 740
- Klimek, 1995, Therapeutic management of mucociliary transport disturbances in allergic rhinitis, Eur. Respir. J., 8, 1298
- Hermens, 1987, The in vitro effect of morphine, fentanyl and sufentanil on ciliary beat frequency of human nasal epithelial tissue, Acta Pharm. Technol., 33, 88
- Gizurarson, 1990, Animal models for intranasal drug delivery studies, Acta Pharm. Nord., 2, 105
- Parr, 1983, Nasal delivery of drugs, Pharm. Int., 4, 202
- Ridley, 1995, The effect of posture on nasal clearance of bioadhesive starch microspheres, STP Pharma. Sci., 5, 442
Cited by
Sorted by citations
Mucoadhesive polymeric platforms for controlled drug delivery
Andrews, G. P., Laverty, T. P., & Jones, D. S. (2008) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.09.028 · Cited by 877
“Such factors make the nasal cavity an attractive route for drug delivery, but they also result in nasal mucosa cells being vulnerable to adverse effects of drugs and excipients delivered intranasally ([102].”
BackgroundLi, J., & Loh, X. J. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.02.011 · Cited by 786
“There have been a lot of developments of drug delivery systems based on CDs, which were used in nasal drug delivery [16–18], in peptide and protein delivery [19], in ophthalmic drug delivery [20], and in many other areas [21–27].”
BackgroundEvaluation of intranasal delivery route of drug administration for brain targeting
Erdő, F., Bors, L. A., Farkas, D., Bajza, Á., & Gizurarson, S. S. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.10.009 · Cited by 773
Mechanism of intranasal drug delivery directly to the brain
Crowe, T. P., Greenlee, M. H. W., Kanthasamy, A. G., & Hsu, W. H. (2018) · Life Sciences · doi:10.1016/j.lfs.2017.12.025 · Cited by 721
“Goblet cells secrete mucin to create the mucus layer, which is turned over at varying rates [30].”
BackgroundIntranasal Drug Delivery: How, Why and What For?
Pires, A., Fortuna, A., Alves, G., & Falcão, A. (2009) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/j3nc79 · Cited by 641
Metadata
- Authors
- Marttin, E., Schipper, N. G. M., Verhoef, J. C., & Merkus, F. W. H. M.
- Corresponding author
- Merkus, Frans W.H.M
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 1998-01
- Volume
- 29
- Issue
- 1-2
- Pages
- 13-38
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2089895093
- Cited by
- 469
- References
- 255
- Citations by year
- 2026: 24 · 2025: 45 · 2024: 26 · 2023: 40 · 2022: 32 · 2021: 34 · 2020: 26 · 2019: 16 · 2018: 27 · 2017: 15 · 2016: 18 · 2015: 14 · 2014: 24 · 2013: 17 · 2012: 15
- FWCI
- 0.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
- Health Sciences › Medicine › Otorhinolaryngology › Sinusitis and nasal conditions
- Keywords
- nasal mucociliary clearance, intranasal drug delivery, ciliary beat frequency, mucus transport, pharmaceutical excipients, nasal drug absorption, residence time, toxicity screening, upper airway diseases, in vitro-in vivo correlation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
