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Cited by 469Advanced Drug Delivery SystemsInhalation and Respiratory Drug DeliverySinusitis and nasal conditions

The DOI matches its Crossref record; 246 of the 255 references it cites were found in a registry or an index.

Nasal mucociliary clearance as a factor in nasal drug delivery

Marttin, Emmeline, Schipper, Nicolaas G.M, Verhoef, J.Coos, Merkus, Frans W.H.M·1998·Advanced Drug Delivery Reviews
DOI 10.1016/s0169-409x(97)00059-8
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Abstract

The nasal mucociliary clearance system transports the mucus layer that covers the nasal epithelium towards the nasopharynx by ciliary beating. Its function is to protect the respiratory system from damage by inhaled substances. Impairment of nasal mucociliary clearance can result in diseases of the upper airways. Therefore, it is important to study the effects of drugs and drug excipients on nasal mucociliary clearance. A large number of methods are used to assess mucociliary clearance. These methods study the effects of drug and excipients on the mucociliary system in vitro or in vivo in animals and humans. In some cases, the results of different in vitro and in vivo measurements do not correlate well. In vitro methods, especially ciliary beat frequency measurements, have been demonstrated to be valuable tools for toxicity screening. However, in vivo studies are essential to confirm the safety of nasal drug formulations. Nasal mucociliary clearance also has implications for nasal drug absorption. Drugs are cleared rapidly from the nasal cavity after intranasal administration, resulting in fast systemic drug absorption. Several approaches are discussed to increase the residence time of drug formulations in the nasal cavity, resulting in improved nasal drug absorption. However, more experimental evidence is needed to support the conclusion that this improved absorption is caused by a longer residence time of the nasal drug formulation.

Overview

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Registry

Crossref · 10.1016/s0169-409x(97)00059-8

Cites

246 of 246 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 10

  1. Lansley, 1990, Changes in the duration of the effective, recovery and rest phases of the ciliary beat cycle induced by intracellular cAMP and Ca2+, J. Cell Biol., 111, 170a
  2. Sanderson, 1993, Measurement of the temperospatial dynamics of intercellular calcium signalling with digital fluorescence microscopy, Am. Lab., 25, 29
  3. Coles, 1983, Effect of topical nasal medications on human nasal ciliary function, Eur. J. Respir. Dis., 126, 121
  4. Su, 1994, Surface–response study of the effect of pH and tonicity on ciliary activity, STP Pharma. Sci., 4, 82
  5. King, 1974, On the transport of mucus and its rheological simulants in ciliated system, Am. Rev. Respir. Dis., 110, 740
  6. Klimek, 1995, Therapeutic management of mucociliary transport disturbances in allergic rhinitis, Eur. Respir. J., 8, 1298
  7. Hermens, 1987, The in vitro effect of morphine, fentanyl and sufentanil on ciliary beat frequency of human nasal epithelial tissue, Acta Pharm. Technol., 33, 88
  8. Gizurarson, 1990, Animal models for intranasal drug delivery studies, Acta Pharm. Nord., 2, 105
  9. Parr, 1983, Nasal delivery of drugs, Pharm. Int., 4, 202
  10. Ridley, 1995, The effect of posture on nasal clearance of bioadhesive starch microspheres, STP Pharma. Sci., 5, 442

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Metadata

Authors
Marttin, E., Schipper, N. G. M., Verhoef, J. C., & Merkus, F. W. H. M.
Corresponding author
Merkus, Frans W.H.M
ORCID
Schipper, Nicolaas G.M
Venue
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Published
1998-01
Volume
29
Issue
1-2
Pages
13-38
ISSN
0169-409X (ISSN-L)
DOI
10.1016/s0169-409x(97)00059-8
OpenAlex
W2089895093
Cited by
469
References
255
Citations by year
2026: 24 · 2025: 45 · 2024: 26 · 2023: 40 · 2022: 32 · 2021: 34 · 2020: 26 · 2019: 16 · 2018: 27 · 2017: 15 · 2016: 18 · 2015: 14 · 2014: 24 · 2013: 17 · 2012: 15
FWCI
0.51
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Advanced Drug Delivery Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
  • Health Sciences › Medicine › Otorhinolaryngology › Sinusitis and nasal conditions
Keywords
nasal mucociliary clearance, intranasal drug delivery, ciliary beat frequency, mucus transport, pharmaceutical excipients, nasal drug absorption, residence time, toxicity screening, upper airway diseases, in vitro-in vivo correlation

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