Sex hormones and bone mineral density in elderly men
Abstract
The aim of this study was to determine the relationships between sex hormones and bone mineral density (BMD) in older men. Community-dwelling men (n = 134, mean age (SD) 69.5 (3.1) years) were recruited from two general practices in Cambridge, UK. Plasma total testosterone and sex hormone binding globulin (SHBG) were assayed and a free androgen index (FAI) was derived as the ratio of total testosterone to SHBG (x 100). Spine and hip BMD were measured by dual energy x-ray absorptiometry using the Hologic QDR-1000. After adjusting for age and body mass index (BMI), the FAI correlated with femoral neck (r = 0.20, P = 0 0.03), intertrochanteric, trochanteric and Ward's Triangle BMD (r = 0.22, P = 0.01). Analysis of variance, with adjustment for age and BMI, showed a progressive upward trend of hip BMD with increasing quartiles of FAI. The findings suggest that free testosterone plays a role in determining bone mineral density in older men.
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The relationship between testosterone levels in aging and bone health is uncertain because studies have produced conflicting results.
“These confounding results leave uncertainty in the relationship between T levels in aging and bone health.”
From Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications (2021) · cites this paper as [173]
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- Authors
- Murphy, S., Khaw, K.-T., Cassidy, A., & Compston, J. E.
- Affiliations
- Addenbrooke's Hospital (GB)
- Corresponding author
- Murphy, Sean
- Venue
- Bone and Mineral
- Publisher
- Elsevier BV
- Published
- 1993-02
- Volume
- 20
- Issue
- 2
- Pages
- 133-140
- ISSN
- 0169-6009 (ISSN-L)
- OpenAlex
- W1980848593
- Cited by
- 187
- References
- 29
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 5 · 2012: 7
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bone and Mineral (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- sex hormones, bone mineral density, older men, free androgen index, total testosterone, sex hormone-binding globulin, hip bone density, spine bone density, femoral neck, osteoporosis
- MeSH terms
- Aged, Aging, Analysis of Variance, Hip, Humans, Male, Sex Hormone-Binding Globulin, Spine, Testosterone, Absorptiometry, Photon, Bone Density, Body Mass Index
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