Chronic IL-1β-Mediated Neuroinflammation Mitigates Amyloid Pathology in a Mouse Model of Alzheimer’s Disease without Inducing Overt Neurodegeneration
Open accessAbstract
Neuroinflammation is a local tissue response to injurious stimuli in the central nervous system (CNS) and is characterized by glial reactivity, induction of cytokines and chemokines, and vascular permeability. The cytokine interleukin (IL)-1β is rapidly induced following CNS insult, and is chronically expressed in neurodegenerative disorders such as Alzheimer's disease (AD). We recently developed a novel method of sustained IL-1β production in the brain to study the link between IL-1β and AD pathogenesis. Utilizing this model, we have previously demonstrated reduction of plaque size and frequency accompanied by a robust neuroinflammatory response. These observations were limited to a single early time point in the course of AD plaque deposition and did not investigate other neurodegenerative endpoints. To extend these observations to other stages of disease progression and evaluate additional pathologic markers, we investigated the effects of age and duration of IL-1β overexpression in the APPswe/PS-1dE9 AD model on a congenic C57BL/6 background. We now report that IL1β overexpression leads to decreased 6E10 immunopositive plaque pathology regardless of age or duration. We also investigated whether IL-1β overexpression led to neuronal apoptosis or cholinergic axonal degeneration in the context of this AD model. Although we could demonstrate apoptosis of infiltrating inflammatory cells, we found no evidence for IL-1 associated apoptosis of neurons or cholinergic axon degeneration even after 5 months of chronic neuroinflammation. Together, these observations point to a neuroprotective role for IL-1β in AD neuropathogenesis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
IL-1β does not influence Aβ production.
“This is consistent with our previously published data showing that IL-1β does not influence Aβ production [4, 6, 7, 28].”
From IL-1β-driven amyloid plaque clearance is associated with an expansion of transcriptionally reprogrammed microglia (2019) · cites this paper as [6]
The Results section (page not provided) reports that IL-1β induction did not significantly alter soluble Aβ, full-length APP, or BACE-1 in the studied mouse model. The Discussion likewise reports no significant change in APP production or processing. These findings support the claim in this model, but not the unqualified statement that IL-1β does not influence Aβ production generally. (LLM, conf=0.86)
Experimental — accuracy not yet measuredSustained hippocampal IL-1β expression decreases amyloid plaque accumulation in APP/PS1 mice.
“As previously described [28], APP/PS1 mice transduced with rAAV2-IL-1β showed significant reductions in hippocampal amyloid plaques compared to mice treated with rAAV2-Phe, as determined by immunohistochemical (IHC) analysis using both 6E10 staining and MX04 (Fig. 1b)”
From IL-1β-driven amyloid plaque clearance is associated with an expansion of transcriptionally reprogrammed microglia (2019) · cites this paper as [6]
The Results section reports significantly reduced hippocampal 6E10-positive plaques after sustained IL-1β upregulation in APP/PS1 mice, supporting the general claim. But this paper induced IL-1β using an IL-1βXAT model with FIV-Cre and an FIV-LacZ control; it does not establish the citing sentence’s rAAV2-IL-1β versus rAAV2-Phe comparison or its MX04 staining result. (LLM, conf=0.89)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.
Griffin, W. S., Stanley, L. C., Ling, C., White, L., MacLeod, V, Perrot, L. J., White, C. L., & Araoz, C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7611 · Cited by 1,777 · see citing works
Wyss-Coray (2006) · doi:10.1038/nm1484 · Cited by 1,284 · see citing works
Simard, A. R., Soulet, D., Gowing, G., Julien, J.-P., & Rivest, S. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.022 · Cited by 1,265 · see citing works
El Khoury, J., Toft, M., Hickman, S. E., Means, T. K., Terada, K., Geula, C., & Luster, A. D. (2007) · Nature Medicine · doi:10.1038/nm1555 · Cited by 915 · see citing works
Inflammatory processes in Alzheimer's disease
Heneka, M. T., & O'Banion, M. K. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.11.017 · Cited by 782 · see citing works
Self-citationInterleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.
Goldgaber, D., Harris, H. W., Hla, T., Maciag, T., DONNELLY, R. J., Jacobsen, J. S., Vitek, M. P., & Gajdusek, D. C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7606 · Cited by 591 · see citing works
The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective
Shaftel, S. S., Griffin, W. S. T., & O'Banion, M. K. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-7 · Cited by 565 · see citing works
Self-citationBuxbaum, J. D., Oishi, M., Chen, H. I., Pinkas‐Kramarski, R., JAFFE, E. A., Gandy, S., & Greengard, P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10075 · Cited by 558 · see citing works
Interleukin-1 Expression in Different Plaque Types in Alzheimerʼs Disease
Griffin, W. S. T., Sheng, J. G., Roberts, G. W., & Mrak, R. E. (1995) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199503000-00014 · Cited by 546 · see citing works
Mogi, M., Harada, M., Narabayashi, H., Inagaki, H., Minami, M., & Nagatsu, T. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12706-3 · Cited by 545 · see citing works
Protective effects of NSAIDs on the development of Alzheimer disease
Vlad, S. C., Miller, D. R., Kowall, N. W., & Felson, D. T. (2008) · Neurology · doi:10.1212/01.wnl.0000311269.57716.63 · Cited by 535 · see citing works
NSAIDs and Alzheimer disease: Epidemiological, animal model and clinical studies
McGeer, P. L., & McGeer, E. G. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.03.013 · Cited by 498 · see citing works
The microglial "activation" continuum: from innate to adaptive responses
Town, T., Nikolic, V., & Tan, J. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-24 · Cited by 456 · see citing works
A modified histochemical technique to visualize acetylcholinesterase-containing axons.
Hedreen, J. C., Bacon, S. J., & Price, D. L. (1985) · Journal of Histochemistry & Cytochemistry · doi:10.1177/33.2.2578498 · Cited by 434 · see citing works
Shaftel, S. S., Kyrkanides, S., Olschowka, J. A., Miller, J.-N. H., Johnson, R. E., & O’Banion, M. K. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31450 · Cited by 433 · see citing works
Self-citationInterleukin‐1: A master regulator of neuroinflammation
Basu, A., Krady, J. K., & Levison, S. W. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20266 · Cited by 367 · see citing works
Can Alzheimer disease be prevented by amyloid-β immunotherapy?
Lemere, C. A., & Masliah, E. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2009.219 · Cited by 351 · see citing works
Jantzen, P. T., Connor, K. E., DiCarlo, G., Wenk, G. L., Wallace, J. L., Rojiani, A. M., Coppola, D., Morgan, D., & Gordon, M. N. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-06-02246.2002 · Cited by 337 · see citing works
Chakrabarty, P., Jansen‐West, K., Beccard, A., Ceballos‐Diaz, C., Levites, Y., Verbeeck, C., Zubair, A. C., Dickson, D., Golde, T. E., & Das, P. (2010) · The FASEB Journal · doi:10.1096/fj.09-141754 · Cited by 328 · see citing works
Inflammaging as a prodrome to Alzheimer's disease
Giunta, B., Fernandez, F., Nikolic, W. V., Obregon, D., Rrapo, E., Town, T., & Tan, J. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-51 · Cited by 327 · see citing works
Reiserer, R. S., Harrison, F. E., Syverud, D. C., & McDonald, M. P. (2007) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2006.00221.x · Cited by 324 · see citing works
Heneka, M. T., Sastre, M., Dumitrescu-Ozimek, L., Dewachter, I., Walter, J., Klockgether, T., & Van Leuven, F. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-22 · Cited by 309 · see citing works
Malm, T. M., Koistinaho, M., Pärepalo, M., Vatanen, T., Ooka, A., Karlsson, S., & Koistinaho, J. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.09.009 · Cited by 301 · see citing works
Wilcock, D. M., Rojiani, A. M., Rosenthal, A., Levkowitz, G., Subbarao, S., Alamed, J., Wilson, D. H., Wilson, N., Freeman, M. J., Gordon, M. N., et al. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1090-04.2004 · Cited by 298 · see citing works
Evidence for glial-mediated inflammation in aged APPSW transgenic mice
Benzing, W. C., Wujek, J. R., Ward, E. K., Shaffer, D. J., Ashe, K. H., Younkin, S. G., & Brunden, K. R. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00065-2 · Cited by 298 · see citing works
Activation of Microglia Acidifies Lysosomes and Leads to Degradation of Alzheimer Amyloid Fibrils
Majumdar, A., Cruz, D., Asamoah, N., Buxbaum, A., Sohar, I., Lobel, P., & Maxfield, F. R. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-10-0975 · Cited by 271 · see citing works
Shaftel, S. S., Carlson, T. J., Olschowka, J. A., Kyrkanides, S., Matousek, S. B., & O'Banion, M. K. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1418-07.2007 · Cited by 243 · see citing works
Self-citationSustained hippocampal IL-1β overexpression impairs contextual and spatial memory in transgenic mice
Hein, A. M., Stasko, M. R., Matousek, S. B., Scott-McKean, J. J., Maier, S. F., Olschowka, J. A., Costa, A. C. S., & O’Banion, M. K. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.10.002 · Cited by 223 · see citing works
Self-citationIntrahippocampal LPS injections reduce Aβ load in APP+PS1 transgenic mice
DiCarlo, G. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00292-5 · Cited by 223 · see citing works
Li, Y., Liu, L., Kang, J., Sheng, J. G., Barger, S. W., Mrak, R. E., & Griffin, W. S. T. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00149.2000 · Cited by 209 · see citing works
Cortical cholinergic fibers in aging and Alzheimer's disease: A morphometric study
Geula, C., & Mesulam, M. M. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90399-0 · Cited by 202 · see citing works
Sheng, J. G., Mrak, R. E., & Griffin, W. S. T. (1997) · Acta Neuropathologica · doi:10.1007/s004010050664 · Cited by 191 · see citing works
Morgan, D., Gordon, M. N., Tan, J., Wilcock, D. M., & Rojiani, A. M. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000178444.33972.e0 · Cited by 174 · see citing works
Reduction of β-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease
Paris, D., Ganey, N. J., Laporte, V., Patel, N. S., Beaulieu‐Abdelahad, D., Bachmeier, C. J., March, A., Ait‐Ghezala, G., & MULLAN, M. J. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-17 · Cited by 169 · see citing works
Pathogenic Mechanisms of Alzheimer's Disease Analyzed in the APP23 Transgenic Mouse Model
Sturchler, C., & Staufenbiel, M. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06915.x · Cited by 168 · see citing works
Sustained expression of interleukin-1β in mouse hippocampus impairs spatial memory
Moore, A. H., Wu, M., Shaftel, S. S., Graham, K. A., & O’Banion, M. K. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.073 · Cited by 159 · see citing works
Self-citationThe effects of aging, injury and disease on microglial function: a case for cellular senescence
Miller, K. R., & Streit, W. J. (2007) · Neuron Glia Biology · doi:10.1017/s1740925x08000136 · Cited by 134 · see citing works
Microglial transplantation increases amyloid‐β clearance in Alzheimer model rats
Takata, K., Kitamura, Y., Yanagisawa, D., Morikawa, S., Morita, M., Inubushi, T., Tsuchiya, D., Chishiro, S., Saeki, M., Taniguchi, T., et al. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.01.009 · Cited by 106 · see citing works
Pihlaja, R., Koistinaho, J., Kauppinen, R., Sandholm, J., Tanila, H., & Koistinaho, M. (2011) · Glia · doi:10.1002/glia.21212 · Cited by 96 · see citing works
McGuinness, M. C., Powers, J. M., Bias, W. B., Schmeckpeper, B. J., Segal, A. H., Gowda, V. C., Wesselingh, S. L., Berger, J., Griffin, D. E., & Smith, K. D. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00020-9 · Cited by 89 · see citing works
Matousek, S. B., Hein, A. M., Shaftel, S. S., Olschowka, J. A., Kyrkanides, S., & O’Banion, M. K. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06759.x · Cited by 55 · see citing works
Self-citationLai, Y., Shaftel, S. S., Miller, J. H., Tallents, R. H., Chang, Y. S., Pinkert, C. A., Olschowka, J. A., Dickerson, I. M., Puzas, J. E., O’Banion, M. K., et al. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21771 · Cited by 52 · see citing works
Self-citationAcetylcholinesterase fibers and the development of senile plaques
Tago, H., McGeer, P. L., & McGeer, E. G. (1987) · Brain Research · doi:10.1016/0006-8993(87)90808-0 · Cited by 51 · see citing works
Barger, S. W. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-2 · Cited by 19 · see citing works
Stahl, T., Reimers, C., Johne, R., Schliebs, R., & Seeger, J. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05069.x · Cited by 16 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Reiserer RS Harrison FE Syverud DC McDonald MP Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease Genes Brain Behav 2007 6 54 65 17233641
Cited by
Sorted by citations
Neuroinflammation and M2 Microglia: The Good, the Bad, and the Inflamed
Cherry, J. D., Olschowka, J. A., & O’Banion, M. K. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-98 · Cited by 1,748 · see citing works
Self-citationMolecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease
Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994 · see citing works
GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease
Jo, S., Yarishkin, O., Hwang, Y. J., Chun, Y. E., Park, M., Woo, D. H., Bae, J. Y., Kim, T., Lee, J., Chun, H., et al. (2014) · Nature Medicine · doi:10.1038/nm.3639 · Cited by 783 · see citing works
Inflammatory process in Alzheimer's Disease
Meraz-Ríos, M. A., Toral-Rios, D., Franco-Bocanegra, D., Villeda-Hernández, J., & Campos-Peña, V. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00059 · Cited by 427 · see citing works
Ghosh, S., Wu, M. D., Shaftel, S. S., Kyrkanides, S., LaFerla, F. M., Olschowka, J. A., & O'Banion, M. K. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4361-12.2013 · Cited by 390 · see citing works
Self-citationThe IL-1β phenomena in neuroinflammatory diseases
Mendiola, A. S., & Cardona, A. E. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-017-1732-9 · Cited by 311 · see citing works
Neuroinflammation in Alzheimer’s disease
Zhang, F., & Jiang, L. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s75546 · Cited by 276 · see citing works
Rodent models of neuroinflammation for Alzheimer’s disease
Nazem, A., Sankowski, R., Bacher, M., & Al‐Abed, Y. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0291-y · Cited by 249 · see citing works
Cherry, J. D., Liu, B., Frost, J. L., Lemere, C. A., Williams, J. P., Olschowka, J. A., & O’Banion, M. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0053275 · Cited by 198 · see citing works
Self-citation11C-PBR28 binding to translocator protein increases with progression of Alzheimer's disease
Kreisl, W. C., Lyoo, C. H., Liow, J., Wei, M. H., Snow, J., Page, E., Jenko, K. J., Morse, C. L., Zoghbi, S. S., Pike, V. W., et al. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.04.011 · Cited by 176 · see citing works
The impact of environmental metals in young urbanites’ brains
Calderón‐Garcidueñas, L., Serrano-Sierra, A., Torres‐Jardón, R., Hongtu Zhu, B., Yuan, Y., Smith, D. A., Delgado‐Chávez, R., Cross, J. V., Medina‐Cortina, H., Kavanaugh, M., et al. (2012) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2012.02.006 · Cited by 157 · see citing works
Arginase 1+ microglia reduce Aβ plaque deposition during IL-1β-dependent neuroinflammation
Cherry, J. D., Olschowka, J. A., & O’Banion, M. K. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0411-8 · Cited by 152 · see citing works
Self-citationYap, J. K. Y., Pickard, B. S., Chan, E. W. L., & Gan, S. Y. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1638-7 · Cited by 127 · see citing works
Targeting innate immunity for neurodegenerative disorders of the central nervous system
Andreasson, K. I., Bachstetter, A. D., Colonna, M., Ginhoux, F., Holmes, C., Lamb, B., Landreth, G., Lee, D. C., Low, D., Lynch, M. A., et al. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13667 · Cited by 126 · see citing works
Self-citationUpstream regulators and downstream effectors of NF-κB in Alzheimer’s disease
Shi, Z.-M., Han, Y.-W., Han, X.-H., Zhang, K., Chang, Y.-N., Hu, Z.-M., Qi, H.-X., Ting, C., Zhen, Z., & Hong, W. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.05.022 · Cited by 125 · see citing works
Boza‐Serrano, A., Yang, Y., Paulus, A., & Deierborg, T. (2018) · Scientific Reports · doi:10.1038/s41598-018-19699-y · Cited by 123 · see citing works
Interleukin-1β in Central Nervous System Injury and Repair.
Hewett, S. J., Jackman, N. A., & Claycomb, R. (2012) · PubMed · Cited by 121 · see citing works
Modulation of inflammation in transgenic models of Alzheimer’s disease
Birch, A. M., Katsouri, L., & Sastre, M. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-25 · Cited by 119 · see citing works
François, A., Terro, F., Janet, T., Bilan, A. R., Paccalin, M., & Page, G. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-151 · Cited by 110 · see citing works
Parthsarathy, V., & Hölscher, C. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.12.012 · Cited by 119 · see citing works
Microglia responses to interleukin‐6 and type I interferons in neuroinflammatory disease
West, P. K., Viengkhou, B., Campbell, I. L., & Hofer, M. J. (2019) · Glia · doi:10.1002/glia.23634 · Cited by 97 · see citing works
Alam, J. J. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150277 · Cited by 88 · see citing works
Hoeijmakers, L., Heinen, Y., van Dam, A.-M., Lucassen, P. J., & Korosi, A. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00398 · Cited by 85 · see citing works
Mao, J., Yang, J., Zhang, Y., Li, T., Wang, C., Xu, L., Hu, Q., Wang, X., Jiang, S., Nie, X., et al. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.05.003 · Cited by 87 · see citing works
Ouyang, Q., Zhao, S. X., Li, S., & Song, C. (2017) · Marine Drugs · doi:10.3390/md15110322 · Cited by 78 · see citing works
Ben-Menachem-Zidon, O., Ben-Menahem, Y., Ben-Hur, T., & Yirmiya, R. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.208 · Cited by 78 · see citing works
Cytokines in the Brain and Neuroinflammation: We Didn’t Starve the Fire!
Konsman, J. P. (2022) · Pharmaceuticals · doi:10.3390/ph15020140 · Cited by 76 · see citing works
Rivera-Escalera, F., Pinney, J. J., Owlett, L., Ahmed, H., Thakar, J., Olschowka, J. A., Elliott, M. R., & O’Banion, M. K. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1645-7 · Cited by 75 · see citing works
“In particular, we found that sustained hippocampal IL-1β expression decreases amyloid plaque accumulation in APPswe/PS1dE9 (APP/PS1) mice [4, 6] and in the”
Self-citationInnate immune activation in Alzheimer’s disease
Wang, M., Miao, D., Cao, X., Tan, L., & Tan, L. (2018) · Annals of Translational Medicine · doi:10.21037/atm.2018.04.20 · Cited by 74 · see citing works
Luís, J. P., Simões, C. J. V., & Brito, R. M. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031731 · Cited by 69 · see citing works
CX3CL1/CX3CR1 in Alzheimer's Disease: A Target for Neuroprotection
Chen, P., Zhao, W.-J., Guo, Y., Xu, J., & Yin, M. (2016) · BioMed Research International · doi:10.1155/2016/8090918 · Cited by 70 · see citing works
Wang, P., Yu, X., Guan, P.-P., Guo, J., Wang, Y., Zhang, Y., Zhao, H., & Wang, Z. (2015) · Cellular and Molecular Immunology · doi:10.1038/cmi.2015.93 · Cited by 61 · see citing works
Xu, Y., Au, N. P. B., & Ma, C. H. E. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.896852 · Cited by 63 · see citing works
Bao, Y., Jiang, L., Chen, H., Zou, J., Liu, Z., & Shi, Y. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000430199 · Cited by 60 · see citing works
Ghahremanitamadon, F., Shahidi, ., Zargooshnia, S., Nikkhah, A., Ranjbar, A., & Asl, S. S. (2014) · BioMed Research International · doi:10.1155/2014/798535 · Cited by 57 · see citing works
Owlett, L. D., Karaahmet, B., Le, L., Belcher, E. K., Dionisio-Santos, D. A., Olschowka, J. A., Elliott, M. R., & O’Banion, M. K. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02397-y · Cited by 53 · see citing works
Self-citationAlzheimer’s disease pathogenesis: standing at the crossroad of lipid metabolism and immune response
Wang, Z., Zhang, L., & Qin, C. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00857-6 · Cited by 54 · see citing works
Endocannabinoid regulation of amyloid-induced neuroinflammation
Vázquez, C., Tolón, R. M., Grande, M. T., Caraza, M., Moreno, M., Koester, E. C., Villaescusa, B., Ruiz‐Valdepeñas, L., Fernández, J., Cravatt, B. F., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.08.003 · Cited by 48 · see citing works
Jansen, D., Zerbi, V., Arnoldussen, I. A. C., Wiesmann, M., Rijpma, A., Fang, X. T., Dederen, P. J. W. C., Mutsaers, M. P. C., Broersen, L. M., Lütjohann, D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075393 · Cited by 47 · see citing works
Wang, S.-S., Li, X., Liu, P., Li, J., & Liu, L. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.972982 · Cited by 42 · see citing works
Welcome, M. O. (2020) · PharmaNutrition · doi:10.1016/j.phanu.2020.100176 · Cited by 41 · see citing works
Potential Immunotargets for Alzheimer's Disease Treatment Strategies
Fernández, P. L., Britton, G. B., & Rao, K. S. J. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-121222 · Cited by 37 · see citing works
Rivera-Escalera, F., Matousek, S. B., Ghosh, S., Olschowka, J. A., & O’Banion, M. K. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.05.018 · Cited by 34 · see citing works
Self-citationTowards A Microbead Occlusion Model of Glaucoma for a Non-Human Primate
Lambert, W. S., Carlson, B. J., Ghose, P., Vest, V. D., Yao, V., & Calkins, D. J. (2019) · Scientific Reports · doi:10.1038/s41598-019-48054-y · Cited by 34 · see citing works
Herr, D., Jew, K., Wong, C., Kennell, A., Gelein, R. M., Chalupa, D., Raab, A., Oberdörster, G., Olschowka, J. A., O’Banion, M. K., et al. (2021) · NeuroToxicology · doi:10.1016/j.neuro.2021.03.010 · Cited by 32 · see citing works
Self-citationLambert, W. S., Carlson, B. J., Formichella, C. R., Sappington, R. M., Ahlem, C., & Calkins, D. J. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00045 · Cited by 31 · see citing works
Vincent, J. C., Garnett, C. N., Watson, J. B., Higgins, E. K., Macheda, T., Sanders, L. G., Roberts, K. N., Shahidehpour, R. K., Blalock, E. M., Quan, N., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02934-3 · Cited by 31 · see citing works
Microglia as a cellular target of diclofenac therapy in Alzheimer’s disease
Stopschinski, B. E., Weideman, R. A., McMahan, D., Jacob, D. A., Little, B. B., Chiang, H.-S., Saez Calveras, N., & Stuve, O. (2023) · Therapeutic Advances in Neurological Disorders · doi:10.1177/17562864231156674 · Cited by 26 · see citing works
Sadowska, G. B., Threlkeld, S. W., Flangini, A., Sharma, S., & Stonestreet, B. S. (2012) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2012.06.001 · Cited by 26 · see citing works
Wu, L., Kalish, B. T., Finander, B., Cao, T., Jin, G., Yahya, T., Levy, E. S., Kukreja, B., LaRovere, E. S., Chung, J. Y., et al. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.0682-21.2021 · Cited by 26 · see citing works
Neuroinflammation and Cognitive Dysfunction in Chronic Disease and Aging
Hein, A. M., & O’Banion, M. K. (2012) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-011-9340-1 · Cited by 22 · see citing works
Self-citationNon-Pharmacological Therapeutic Options for the Treatment of Alzheimer’s Disease
Huynh, Q., Elangovan, S., & Holsinger, R. M. D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911037 · Cited by 20 · see citing works
Torres, K., Lima, G. S., Fiamoncini, C. M., de Rezende, V. B., Pereira, P. A., Bicalho, M. A. C., de Moraes, E. N., & Romano‐Silva, M. A. (2013) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.3973 · Cited by 20 · see citing works
Da-chuan, X., Liu, J., Ma, Y., Tian, S., Zhang, L., Zhao, M., & Zhang, Y. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.139481 · Cited by 19 · see citing works
Evaluating the Effect of Interleukin-4 in the 3xTg Mouse Model of Alzheimer’s Disease
Dionisio-Santos, D. A., Behrouzi, A., Olschowka, J. A., & O’Banion, M. K. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00441 · Cited by 20 · see citing works
Self-citationDrugs for Targeted Therapies of Alzheimer’s Disease
Tam, C., Wong, J. H., Ng, T. B., Tsui, S. K., & Zuo, T. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180430150940 · Cited by 15 · see citing works
Aparicio, N., Grande, M. T., Esteban, S. R. D. M., López, A., Ruiz‐Pérez, G., Amores, M., Vázquez, C., Martínez-Relimpio, A. M., Pazos, M. R., Cravatt, B. F., et al. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.09.009 · Cited by 16 · see citing works
Motta, C., Assogna, M., Bonomi, C. G., Lorenzo, F. D., Nuccetelli, M., Mercuri, N. B., Koch, G., & Martorana, A. (2023) · European Journal of Neurology · doi:10.1111/ene.15691 · Cited by 15 · see citing works
Inflammatory Cytokine IL-1β Downregulates Endothelial LRP1 via MicroRNA-mediated Gene Silencing
Hsu, H.-W., Rodríguez‐Ortiz, C. J., Zumkehr, J., & Kitazawa, M. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.11.021 · Cited by 15 · see citing works
Srinivasan, S., Kancheva, D., Ren, S. D., Saito, T., Jans, M., Boone, F., Vandendriessche, C., Paesmans, I., Maurin, H., Vandenbroucke, R. E., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1323409 · Cited by 14 · see citing works
IL-1R-/- alleviates cognitive deficits through microglial M2 polarization in AD mice
Wang, H., Peng, G., Wang, B., Yin, H., Fang, X., He, F., Zhao, D., Liu, Q., & Shi, L. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.11.020 · Cited by 13 · see citing works
Lykhmus, O., Kalashnyk, O., Koval, L., Voytenko, L. P., Uspenska, K., Комісаренко, С. В., Deryabina, О. G., Shuvalova, N. S., Кордюм, В. А., Ustymenko, A., et al. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.06.004 · Cited by 12 · see citing works
Kumar, P., Mathew, S., Gamage, R. V., Bodkin, F., Doyle, K., Rosetti, I., Wagnon, I. M., Zhou, X., Raju, R., Gyengési, E., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241311086 · Cited by 11 · see citing works
Naik, S. V., Katariya, R., Shelke, S., Patravale, V. B., Umekar, M. J., Kotagale, N. R., & Taksande, B. G. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175821 · Cited by 10 · see citing works
Effects of diverse Types of Toxoplasma gondii on the outcome of Alzheimer's disease in the rat model
Galeh, T. M., Ghazvini, H., Mohammadi, M., Sarvi, S., Azizi, S., Asgarian‐Omran, H., Hajizadeh, F., & Daryani, A. (2022) · Microbial Pathogenesis · doi:10.1016/j.micpath.2022.105931 · Cited by 9 · see citing works
Cherry, J. D., Williams, J. P., O’Banion, M. K., & Olschowka, J. A. (2013) · Radiation Research · doi:10.1667/rr3363.1 · Cited by 9 · see citing works
Self-citationMendoza‐Marí, Y., Rai, V., Radwan, M. M., Brazdzionis, J., Connett, D. A., Miulli, D. E., & Agrawal, D. K. (2024) · Journal of Surgery and Research · doi:10.26502/jsr.10020338 · Cited by 8 · see citing works
Madadi, S., & Mehdi, M. (2014) · Avicenna Journal of Neuro Psych Physiology · doi:10.17795/ajnpp-19713 · Cited by 7 · see citing works
Özen, Í., Clausen, F., Flygt, J., Marklund, N., & Paul, G. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1378203 · Cited by 6 · see citing works
Conserved Blood Transcriptome Patterns Highlight microRNA and Hub Gene Drivers of Neurodegeneration
Cerna, J. L. O. D. L., Talubo, N. D. D., Villanueva, B. H. A., Tsai, P., & Tayo, L. L. (2025) · Genes · doi:10.3390/genes16101178 · Cited by 4 · see citing works
Anti-inflammatory microglial cell function in the light of the latest scientific research
Łabuzek, K., Skrudlik, E., Gabryel, B., & Okopień, B. (2015) · Annales Academiae Medicae Silesiensis · doi:10.18794/aams/32608 · Cited by 4 · see citing works
Pansieri, J., Pisa, M., Yee, S., Gutnikova, A., Ridgeon, E., Hickman, R., Spencer, J., Esiri, M., & DeLuca, G. (2024) · bioRxiv · doi:10.1002/ana.27231 · Cited by 3 · see citing works
Models of neuroinflammation for the assessment of kappa-opioid receptor ligands
Kalitin, K. Y., Спасов, А. А., & Mukha, O. Y. (2023) · Pharmacy & Pharmacology · doi:10.19163/2307-9266-2023-11-1-4-18 · Cited by 2 · see citing works
Molecular etiopathogenesis of neurodegenerative diseases
Divya, D., Thekkekkara, D., Sai, T. E., Ramakrishna, D., Manjula, S. N., & Goswami, S. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-28822-7.00002-7 · Cited by 2 · see citing works
Biomarkers of heavy metal–induced neurotoxicity: insights into mechanisms and disease impact
Bharadava, K., Kumar, S., & Kaushal, R. S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-36575-1.00015-7 · Cited by 1 · see citing works
Microglia in the Alzheimers brain: a help or a hindrance?
Vollert, C. T., & Eriksen, J. L. (2014) · AIMS neuroscience · doi:10.3934/neuroscience.2014.3.210
Ghosh, S., Shaftel, S. S., Kyrkanides, S., Olschowka, J. A., & O’Banion, M. K. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.10.430570
Self-citationOwlett, L. D., Karaahmet, B., Le, L., Belcher, E. K., Dionisio-Santos, D. A., Olschowka, J. A., Elliott, M. R., & O’Banion, M. K. (2021) · Research Square · doi:10.21203/rs.3.rs-991983/v1
Self-citationZhang, L. (2023) · Traditional Chinese Medicine · doi:10.12677/tcm.2023.126187
Vincent, J. C., Garnett, C. N., Watson, J. B., Higgins, E. K., Macheda, T., Sanders, L. G., Roberts, K. N., Shahidehpour, R. K., Blalock, E. M., Quan, N., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26632489
Vincent, J. C., Garnett, C. N., Watson, J. B., Higgins, E. K., Macheda, T., Sanders, L. G., Roberts, K. N., Shahidehpour, R. K., Blalock, E. M., Quan, N., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26632492
Owlett, L. D., Karaahmet, B., Le, L., Belcher, E. K., Dionisio-Santos, D. A., Olschowka, J. A., Elliott, M. R., & O’Banion, M. K. (2022) · Figshare · doi:10.6084/m9.figshare.19136122
Self-citationVisceral adipose tissue differentially affects tau and Aβ pathology in 3xTg-AD mice
Trujillo‐Estrada, L., Bettinetti‐Luque, M., Andreo‐Lopez, J., Cunha, C. D., Morales‐Cabello, M., Campos‐Moreno, C., Sánchez‐Mejías, E., Forner, S., Martini, A. C., Sanchez-Varo, R. M., et al. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-02964-3
Pacheco-Sánchez, B., López-Gambero, A. J., Gavito, A., Rivera, P., Suárez, J., Sanjuan, C., Nilsson, P., Tambaro, S., & de Fonseca, F. R. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119629
Piłat, D., Baranger, K., & Rivera, S. (2026) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2026.07.004
- Authors
- Matousek, S. B., Ghosh, S., Shaftel, S. S., Kyrkanides, S., Olschowka, J. A., & O’Banion, M. K.
- Affiliations
- University of Rochester Medicine (US)
- Stony Brook University Hospital (US)
- Corresponding author
- O’Banion, M. Kerry
- Venue
- Journal of Neuroimmune Pharmacology
- Published
- 2011-12-16
- Volume
- 7
- Issue
- 1
- Pages
- 156-164
- ISSN
- 1557-1890 (ISSN-L)
- 1557-1904
- PMC
- PMC3302720
- OpenAlex
- W2052020187
- Cited by
- 86
- References
- 45
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 9 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 9 · 2014: 8 · 2013: 7 · 2012: 7
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neuroimmune Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (F31AG031667, R01AG030149)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- IL-1β, neuroinflammation, Alzheimer's disease, amyloid plaques, neuroprotection, neuronal apoptosis, neurodegeneration, age-dependent effects
- MeSH terms
- Alzheimer Disease, Animals, Brain, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Immunohistochemistry, Inflammation, Mice, Inbred C57BL, Mice, Transgenic, Neuroglia, Neurons, Blotting, Western, Amyloid beta-Peptides, Microscopy, Confocal, Mice, Interleukin-1beta
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
