Amyloid β Protein in Plasma as a Diagnostic Marker for Alzheimer’s Disease
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Other published studies of plasma Aβ in AD have shown no change or a slight increase in plasma Aβ42.
“Other published studies of plasma A in AD have shown no change or a slight increase in plasma A42 (Iwatsubo, 1998;Matsubara et al., 1999).”
From Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease (2001) · cites this paper as Iwatsubo, 1998
Cites
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., et al. (1995) · Nature · doi:10.1038/375754a0 · Cited by 4,051 · see citing works
Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T. D., Hardy, J., Hutton, M., Kukull, W., et al. (1996) · Nature Medicine · doi:10.1038/nm0896-864 · Cited by 2,599 · see citing works
Candidate gene for the chromosome 1 familial Alzheimer’s disease locus
Levy-Lahad, E., Wasco, W., Poorkaj, P., Romano, D. M., Oshima, J., Pettingell, W. H., Yu, C.-E., Jondro, P. D., Schmidt, S. D., Wang, K., et al. (1995) · Science · doi:10.1126/science.7638622 · Cited by 2,577 · see citing works
Jarrett, J. T., Berger, E. P., & Lansbury, P. T. (1993) · Biochemistry · doi:10.1021/bi00069a001 · Cited by 2,022 · see citing works
Iwatsubo, T., Odaka, A., Suzuki, N., Mizusawa, H., Nukina, N., & Ihara, Y. (1994) · Neuron · doi:10.1016/0896-6273(94)90458-8 · Cited by 1,774 · see citing works
Self-citationBorchelt, D. R., Thinakaran, G., Eckman, C. B., Lee, M. K., Davenport, F., Ratovitsky, T., Prada, C.-M., Kim, G., Seekins, S., Yager, D., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80230-5 · Cited by 1,478 · see citing works
Suzuki, N., Cheung, T. T., Cai, X.-D., Odaka, A., Otvos, L., Eckman, C., Golde, T. E., & Younkin, S. G. (1994) · Science · doi:10.1126/science.8191290 · Cited by 1,471 · see citing works
The Clinical Diagnosis of Alzheimer's Disease
Wade, J. P. H., Mirsen, T. R., Hachinski, V. C., Fisman, M., Lau, C. S., & Merskey, H. (1987) · Archives of Neurology · doi:10.1001/archneur.1987.00520130016010 · Cited by 1,416 · see citing works
Motter, R., Vigo‐Pelfrey, C., Kholodenko, D., Barbour, R., Johnson‐Wood, K., Galasko, D., Chang, L., Miller, B., Clark, C., Green, R., et al. (1995) · Annals of Neurology · doi:10.1002/ana.410380413 · Cited by 701 · see citing works
Amyloid β protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in down Syndrome
Iwatsubo, T., Mann, D. M. A., Odaka, A., Suzuki, N., & Ihara, Y. (1995) · Annals of Neurology · doi:10.1002/ana.410370305 · Cited by 380 · see citing works
Self-citationTomita, T., Maruyama, K., Saido, T. C., Kume, H., Shinozaki, K., Tokuhiro, S., Capell, A., Walter, J., Grünberg, J., Haass, C., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.5.2025 · Cited by 379 · see citing works
Self-citationTau in cerebrospinal fluid: A potential diagnostic marker in Alzheimer's disease
Arai, H., Terajima, M., Miura, M., Higuchi, S., Muramatsu, T., Machida, N., Seiki, H., Takase, S., Clark, C., Lee, V. M., et al. (1995) · Annals of Neurology · doi:10.1002/ana.410380414 · Cited by 314 · see citing works
Long amyloid beta-protein secreted from wild-type human neuroblastoma IMR-32 cells.
Asami-Odaka, A., Ishibashi, Y., Kikuchi, T., Kitada, C., & Suzuki, N. (1995) · Biochemistry · doi:10.1021/bi00032a022 · Cited by 153 · see citing works
Kosaka, T., Imagawa, M., Seki, K., Arai, H., Sasaki, H., Tsuji, S., Asami-Odaka, A., Fukushima, T., Imai, K., & Iwatsubo, T. (1997) · Neurology · doi:10.1212/wnl.48.3.741 · Cited by 106 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation
Nilsberth, C., Westlind-Danielsson, A., Eckman, C. B., Condron, M. M., Axelman, K., Forsell, C., Stenh, C., Luthman, J., Teplow, D. B., Younkin, S. G., et al. (2001) · Nature Neuroscience · doi:10.1038/nn0901-887 · Cited by 1,209 · see citing works
Kawarabayashi, T., Younkin, L. H., Saido, T. C., Shoji, M., Ashe, K. H., & Younkin, S. G. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-02-00372.2001 · Cited by 1,053 · see citing works
“Other published studies of plasma Ab in AD have shown no change or a slight increase in plasma Ab42 (Iwatsubo, 1998; Matsubara et al., 1999).”
BackgroundReger, M. A., Watson, G. S., Green, P. S., Baker, L. D., Cholerton, B., Fishel, M. A., Plymate, S. R., Cherrier, M. M., Schellenberg, G. D., Frey, W. H., et al. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-13309 · Cited by 518 · see citing works
Plasma Aβ40 and Aβ42 and Alzheimer’s disease: Relation to age, mortality, and risk
Mayeux, R., Honig, L. S., Tang, M.-X., Manly, J., Stern, Y., Schupf, N., & Mehta, P. D. (2003) · Neurology · doi:10.1212/01.wnl.0000091890.32140.8f · Cited by 434 · see citing works
Plasma Aβ1–40 and Aβ1–42 and the risk of dementia: a prospective case-cohort study
van Oijen, M., Hofman, A., Soares, H. D., Koudstaal, P. J., & Breteler, M. M. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70501-4 · Cited by 458 · see citing works
Diagnosis and treatment of dementia: 2. Diagnosis
Feldman, H., Jacova, C., Robillard, A., Garcia, A. A., Chow, T. W., BORRIE, M. J., Schipper, H. M., Blair, M., Kertesz, A., & Chertkow, H. M. (2008) · Canadian Medical Association Journal · doi:10.1503/cmaj.070798 · Cited by 350 · see citing works
Amyloid-Associated Depression: A Prodromal Depression of Alzheimer Disease?
Sun, X., Steffens, D. C., Au, R., Folstein, M., Summergrad, P., Yee, J., Rosenberg, I., Mwamburi, D. M., & Qiu, W. Q. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.5.542 · Cited by 174 · see citing works
Plasma Amyloid-β as a Biomarker in Alzheimer's Disease: The AIBL Study of Aging
Lui, J., Laws, S., Li, Q.-X., Villemagne, V., Ames, D., Brown, B., Bush, A., Ruyck, K. D., Dromey, J., Ellis, K., et al. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-090249 · Cited by 141 · see citing works
Protein misfolding in Alzheimer’s and Parkinson’s disease: genetics and molecular mechanisms
Forloni, G., Terreni, L., Bertani, I., Fogliarino, S., Invernizzi, R. W., Assini, A., Ribizzi, G., Negro, A., Calabrese, E., & Volonté, M. A. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00076-3 · Cited by 132 · see citing works
Evaluation of heme oxygenase-1 as a systemic biological marker of sporadic AD
Schipper, H. M., Chertkow, H. M., Mehindate, K., Frankel, D., Melmed, C., & Bergman, H. (2000) · Neurology · doi:10.1212/wnl.54.6.1297 · Cited by 117 · see citing works
Zhou, Y., Li, W., Xu, L., & Chen, L. (2011) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2011.02.006 · Cited by 117 · see citing works
Anderson, J. J., Holtz, G., Baskin, P. P., Turner, M., Rowe, B. A., Wang, B., Kounnas, M. Z., Lamb, B. T., Barten, D. M., Felsenstein, K. M., et al. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.11.015 · Cited by 92 · see citing works
Moir, R. D., Tseitlin, K. A., Soscia, S. J., Hyman, B. T., Irizarry, M. C., & Tanzi, R. E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414176200 · Cited by 88 · see citing works
Differential modulation of plasma β-amyloid by insulin in patients with Alzheimer disease
Kulstad, J. J., Green, P. S., Cook, D. G., Watson, G. S., Reger, M. A., Baker, L. D., Plymate, S. R., Asthana, S., Rhoads, K., Mehta, P. D., et al. (2006) · Neurology · doi:10.1212/01.wnl.0000216274.58185.09 · Cited by 82 · see citing works
Protective effects of Eucommia ulmoides Oliv. bark and leaf on amyloid β-induced cytotoxicity
Zhou, Y., Liang, M., Li, W., Li, K., Li, P., Hu, Y., & Zhong-lin, Y. (2009) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2009.05.012 · Cited by 60 · see citing works
Guan, Z. Z., Miao, H., Tian, J., Unger, C., Nordberg, A. K., & Zhang, X. (2001) · Journal of Neural Transmission · doi:10.1007/s007020100017 · Cited by 56 · see citing works
Hock, C., Maddalena, A. S., Heuser, I., Naber, D., Oertel, W. H., von der Kammer, H., Wienrich, M., Raschig, A., Deng, M., Growdon, J. H., et al. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06937.x · Cited by 54 · see citing works
Plasma amyloid-β levels, cerebral atrophy and risk of dementia: a population-based study
Hilal, S., Wolters, F. J., Verbeek, M. M., Vanderstichele, H., Ikram, M. K., Stoops, E., Ikram, M. A., & Vernooij, M. W. (2018) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0395-6 · Cited by 52 · see citing works
Maximizing the Potential of Plasma Amyloid-Beta as a Diagnostic Biomarker for Alzheimer’s Disease
Oh, E. S., Troncoso, J. C., & Tucker, S. M. F. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8035-0 · Cited by 35 · see citing works
Competitive ELISA studies of neural thread protein in urine in Alzheimer's disease
Levy, S., McConville, M., Lazaro, G. A., & Averback, P. (2007) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.20159 · Cited by 32 · see citing works
Plasma Aβ: A Possible Missing Link Between Alzheimer Disease and Diabetes
Sato, N., & Morishita, R. (2013) · Diabetes · doi:10.2337/db12-1549 · Cited by 30 · see citing works
Takeda, S., Sato, N., Rakugi, H., & Morishita, R. (2010) · Molecular BioSystems · doi:10.1039/c003148h · Cited by 30 · see citing works
Takeda, S., Sato, N., Uchio‐Yamada, K., Yu, H., Moriguchi, A., Rakugi, H., & Morishita, R. (2012) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000338704 · Cited by 29 · see citing works
The Relationship of Plasma Aβ Levels to Dementia in Aging Individuals With Down Syndrome
Matsuoka, Y., Andrews, H., Becker, A. G., Gray, A. J., Mehta, P. D., Sano, M. C., Dalton, A. J., & Aisen, P. S. S. (2009) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e3181aba61e · Cited by 29 · see citing works
Elevation of plasma β-amyloid level by glucose loading in Alzheimer mouse models
Takeda, S., Sato, N., Uchio‐Yamada, K., Sawada, K., Kunieda, T., Takeuchi, D., Kurinami, H., Shinohara, M., Rakugi, H., & Morishita, R. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.05.037 · Cited by 25 · see citing works
The role of biologic markers in the diagnosis of Alzheimer's disease
Schipper, H. (2007) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2007.07.015 · Cited by 26 · see citing works
Aoki, K., Konno, M., Honda, K., Abe, T., Nagata, T., Takehara, M., Sugasawa, T., Takekoshi, K., & Ohmori, H. (2020) · Geriatrics · doi:10.3390/geriatrics5030048 · Cited by 17 · see citing works
Can Chiroptical Spectroscopy be Used for the Analysis of Blood Plasma?
Tatarkovič, M., Fišar, Z., Raboch, J., Jirák, R., & Setnička, V. (2012) · Chirality · doi:10.1002/chir.22063 · Cited by 17 · see citing works
Plasma amyloid-β, Aβ1-42, load is reduced by haemodialysis
Rubio, I., Caramelo, C. A., Gil, A., López, M. D., & de Yébenes, J. G. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-10413 · Cited by 13 · see citing works
Sun, X., Bhadelia, R. A., Liebson, E. S., Bergethon, P. R., Folstein, M. F., Zhu, J., Mwamburi, D. M., Patz, S., & Qiu, W. Q. (2010) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2568 · Cited by 12 · see citing works
Amyloid Biomarkers in Conformational Diseases at Face Value: A Systematic Review
Avila-Vazquez, M., Altamirano-Bustamante, N. F., & Altamirano‐Bustamante, M. M. (2017) · Molecules · doi:10.3390/molecules23010079 · Cited by 10 · see citing works
Biological Markers and Alzheimer Disease: A Canadian Perspective
Schipper, H. M. (2010) · International Journal of Alzheimer s Disease · doi:10.4061/2010/978182 · Cited by 8 · see citing works
a prospective case-cohort study
van Oijen, M., Albert Hofman, D., Breteler, M. M. B., Koudstaal, P. J., & Soares, H. D. (2006) · Cited by 5 · see citing works
Peripheral Markers of Alzheimer’s
Percy, M. E., Andrews, D. F., & Potter, H. (2000) · Humana Press eBooks · doi:10.1007/978-1-59259-005-6_9 · Cited by 3 · see citing works
Song, C., Li, F., Wang, L., Shi, Y., & Shen, Z. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220165 · Cited by 1 · see citing works
Patel, S. (2019) · TSpace (University of Toronto)
- Authors
- Iwatsubo, T.
- Affiliations
- The University of Tokyo (JP)
- Corresponding author
- Iwatsubo, T.
- ORCID
- Iwatsubo, T.
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 1998-03
- Volume
- 19
- Issue
- 2
- Pages
- 161-163
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2027136096
- Cited by
- 37
- References
- 15
- Citations by year
- 2022: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2013: 1 · 2012: 2
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Keywords
- Radix Salvia miltiorrhiza, Alzheimer's disease, amyloid-beta, PC12 cells, tanshinones, polyphenols, salvianolic acid B, danshensu, acetylcholinesterase inhibition, calcium influx, apoptosis, senile dementia, traditional Chinese medicine
- MeSH terms
- Alzheimer Disease, Enzyme-Linked Immunosorbent Assay, Heterozygote, Humans, Biomarkers, Amyloid beta-Peptides
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review