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Cited by 145Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsInflammatory mediators and NSAID effects

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

NSAIDs and incident Alzheimer’s disease. the Rotterdam study

In ’t Veld, B.A, Launer, L.J, Hoes, A.W, Ott, A, Hofman, A, Breteler, M.M.B, Stricker, B.H.Ch·1998·Neurobiology of Aging
DOI 10.1016/s0197-4580(98)00096-7
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Abstract

Recent studies suggest that the use of nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the risk for Alzheimer's disease (AD). We investigated the relation of NSAID use over a 10-year period and the risk for incident AD using a nested case-control design in the population-based Rotterdam Study. The study was performed in 306 subjects; 74 Alzheimer patients diagnosed according to NINCDS-ADRDRA criteria and 232 age and sex-matched controls. NSAID use was abstracted from general practitioners' medical records and expressed as cumulative prescription days. The relative risk for AD associated with long-term use (> or = 2 months) was 0.95 (95% CI: 0.46-1.99) as compared to nonusers, after controlling for possible confounders. In a separate examination, subjects who had more than 6 months of prescription days had a reduced relative risk for AD (RR = 0.74 (95% CI: 0.20-2.72). In an age-stratified analysis the effect in long-term users was evident in those aged 85 and under; 0.53 (95% CI: 0.15-1.77). All risk estimates were lower when the last 2 years of exposure were excluded from the analyses. Our point estimates in subjects younger than 85 years and in subjects using NSAIDs for 6 months or more are consistent with the hypothesis that long-term use of NSAIDs reduces the risk for AD. However, overall there was no association between NSAID use and the risk for incident AD.

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Research works printed but not linked: 17

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Metadata

Authors
In ’t Veld, B. A., Launer, L. J., Hoes, A. W., Ott, A., Hofman, A., Breteler, M. M. B., & Stricker, B. H. C.
Affiliations
  • Erasmus MC (NL)
  • Utrecht University (NL)
  • Dutch Health Care Inspectorate (NL)
Corresponding author
Launer, L.J
ORCID
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
1998-11
Volume
19
Issue
6
Pages
607-611
ISSN
0197-4580 (ISSN-L)
DOI
10.1016/s0197-4580(98)00096-7
OpenAlex
W1965756304
Cited by
145
References
0
Citations by year
2024: 2 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 1 · 2019: 6 · 2018: 2 · 2017: 3 · 2016: 6 · 2015: 1 · 2014: 5 · 2013: 4 · 2012: 5
FWCI
7.98
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
  • Rivm (National Institute for Public Health and the Environment) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Keywords
nonsteroidal anti-inflammatory drugs, Alzheimer's disease, long-term NSAID use, Rotterdam Study
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Anti-Inflammatory Agents, Non-Steroidal, Female, Humans, Male, Middle Aged, Risk, Logistic Models, Case-Control Studies

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