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Cited by 145Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsInflammatory mediators and NSAID effects

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NSAIDs and incident Alzheimer’s disease. the Rotterdam study

In ’t Veld, B.A, Launer, L.J, Hoes, A.W, Ott, A, Hofman, A, Breteler, M.M.B, Stricker, B.H.Ch·1998·Neurobiology of Aging
DOI 10.1016/s0197-4580(98)00096-7
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Abstract

Recent studies suggest that the use of nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the risk for Alzheimer's disease (AD). We investigated the relation of NSAID use over a 10-year period and the risk for incident AD using a nested case-control design in the population-based Rotterdam Study. The study was performed in 306 subjects; 74 Alzheimer patients diagnosed according to NINCDS-ADRDRA criteria and 232 age and sex-matched controls. NSAID use was abstracted from general practitioners' medical records and expressed as cumulative prescription days. The relative risk for AD associated with long-term use (> or = 2 months) was 0.95 (95% CI: 0.46-1.99) as compared to nonusers, after controlling for possible confounders. In a separate examination, subjects who had more than 6 months of prescription days had a reduced relative risk for AD (RR = 0.74 (95% CI: 0.20-2.72). In an age-stratified analysis the effect in long-term users was evident in those aged 85 and under; 0.53 (95% CI: 0.15-1.77). All risk estimates were lower when the last 2 years of exposure were excluded from the analyses. Our point estimates in subjects younger than 85 years and in subjects using NSAIDs for 6 months or more are consistent with the hypothesis that long-term use of NSAIDs reduces the risk for AD. However, overall there was no association between NSAID use and the risk for incident AD.

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Research works printed but not linked: 17

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Metadata

Authors
In ’t Veld, B. A., Launer, L. J., Hoes, A. W., Ott, A., Hofman, A., Breteler, M. M. B., & Stricker, B. H. C.
Affiliations
  • Erasmus MC (NL)
  • Utrecht University (NL)
  • Dutch Health Care Inspectorate (NL)
Corresponding author
Launer, L.J
ORCID
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
1998-11
Volume
19
Issue
6
Pages
607-611
ISSN
0197-4580 (ISSN-L)
DOI
10.1016/s0197-4580(98)00096-7
OpenAlex
W1965756304
Cited by
145
References
0
Citations by year
2024: 2 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 1 · 2019: 6 · 2018: 2 · 2017: 3 · 2016: 6 · 2015: 1 · 2014: 5 · 2013: 4 · 2012: 5
FWCI
7.98
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
  • Rivm (National Institute for Public Health and the Environment) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Keywords
nonsteroidal anti-inflammatory drugs, Alzheimer's disease, long-term NSAID use, Rotterdam Study
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Anti-Inflammatory Agents, Non-Steroidal, Female, Humans, Male, Middle Aged, Risk, Logistic Models, Case-Control Studies

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