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Cited by 29Hepatitis B Virus Studiesvaccines and immunoinformatics approachesImmunotherapy and Immune Responses

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

HLA-A2.1 restricted peptides from the HBx antigen induce specific CTL responses in vitro and in vivo

Hwang, Yu Kyeong, Kim, Nam Kyung, Park, Jung Min, Lee, Ki-young, Han, Won-Kyo, Kim, Hyung-Il, Cheong, Hong Seok·2002·Vaccine
DOI 10.1016/s0264-410x(02)00297-9
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Abstract

The HBx-derived, HLA-A2.1 restricted peptides, XEP-3, XEP-4, and XEP-6, induced activation of specific CTLs from patients with HBV in vitro. XEP-6 peptide induced the strongest response among the three peptides in CTLs from the blood samples of patients that were HBsAg positive. It was not clear whether the stage of disease (chronic infection, cirrhosis or hepatoma) was related to the responsiveness of the CTLs to each peptide. We vaccinated HLA-A2/K(b) transgenic mice with these peptides encapsulated in pH-sensitive liposomes at various concentrations and tested their ability to protect against challenge with rVV-HBx. Mice immunized with encapsulated peptides were protected against viral challenge whereas those immunized with empty liposomes were not. In general, 5 micro g of each peptide per head inoculation was sufficient to give protection after 2 weeks. After 3 weeks, this protective effect was increased. This effect of time was more important on the level of protection than the initial dose of the peptide. To explain the protective effect, IFN-gamma secreting CD8(+) cells isolated from mice 3 weeks after immunization were analyzed ex vivo. There was little dose dependency of peptide on IFN-gamma secretion except for XEP-3. The variations in the results may reflect the chemical properties of the peptides, such as solubility and binding affinity. In conclusion, epitope peptides derived from HBx can induce specific CTL activation and lead to cellular immunity in vitro and…

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Crossref · 10.1016/s0264-410x(02)00297-9

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Research works printed but not linked: 1

  1. Park, 2000, Identification of H-2K(b)-restricted T-cell epitopes within the nucleocapsid protein of Hantaan virus and establishment of cytotoxic T-cell clones, J. Med. Virol., 60, 189, 10.1002/(SICI)1096-9071(200002)60:2<189::AID-JMV14>3.0.CO;2-O · DOI

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Metadata

Authors
Hwang, Y. K., Kim, N. K., Park, J. M., Lee, K.-Y., Han, W.-K., Kim, H.-I., & Cheong, H. S.
Affiliations
Ajou University (KR)
ORCID
Venue
Vaccine
Publisher
Elsevier BV
Published
2002-11
Volume
20
Issue
31-32
Pages
3770-3777
ISSN
0264-410X (ISSN-L)
DOI
10.1016/s0264-410x(02)00297-9
OpenAlex
W2080493298
Cited by
29
References
29
Citations by year
2025: 1 · 2022: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2012: 3
FWCI
1.77
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Vaccine (publishedVersion)
  • PubMed (publishedVersion)
  • AJOU Open Repository (Ajou University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
cytotoxic T lymphocytes, hepatitis B virus, peptide vaccine, pH-sensitive liposomes, CD8+ T cell activation, interferon-gamma, protective immunity, viral challenge protection
MeSH terms
Animals, Cell Line, Cytotoxicity, Immunologic, Hepatitis B virus, Humans, Male, Mice, Transgenic, Peptides, T-Lymphocytes, Cytotoxic, Trans-Activators, HLA-A2 Antigen, Hepatitis B, Chronic, Mice, Viral Regulatory and Accessory Proteins

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.