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Mechanisms by which maternal antibodies influence infant vaccine responses: review of hypotheses and definition of main determinants
Open accessAbstract
Several mechanisms have been suggested as mediating the inhibitory influence of maternal antibodies (MatAb) on infant responses. This inhibition is B cell determinant-specific, depends on the ratio between MatAb titers at the time of immunization and the dose of vaccine antigen, and leaves infant T cell responses largely unaffected. Neutralization of vaccine replication or FcgammaRIIB-mediated inhibitory signalling to infant B cells would not account for these characteristics. In contrast, determinant-specific masking of B cell epitopes and APC uptake of MatAb:vaccine antigen immune complexes, followed by antigen processing and presentation, explain the pattern of pre-clinical and clinical responses to infant vaccines. This allows the definition of the main determinants of the influence of MatAb on infant immunity.
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Cited by
IgG placental transfer in healthy and pathological pregnancies
Palmeira, P., Quinello, C., Silveira-Lessa, A. L., Zago, C. A., & Carneiro-Sampaio, M. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/985646 · Cited by 1,037
A Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Infants
The RTS, S. C. T. P. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1208394 · Cited by 752
Perspectives on Immunoglobulins in Colostrum and Milk
Hurley, W. L., & Theil, P. K. (2011) · Nutrients · doi:10.3390/nu3040442 · Cited by 687
B-cell responses to vaccination at the extremes of age
Siegrist, C.-A., & Aspinall, R. (2009) · Nature Reviews Immunology · doi:10.1038/nri2508 · Cited by 659
Self-citationEarly waning of maternal measles antibodies in era of measles elimination: longitudinal study
Leuridan, E., Hens, N., Hutse, V., Ieven, M., Aerts, M., & Van Damme, P. (2010) · BMJ · doi:10.1136/bmj.c1626 · Cited by 284
Metadata
- Authors
- Siegrist, C.
- Venue
- Vaccine
- Publisher
- Elsevier BV
- Published
- 2003-07-28
- Volume
- 21
- Issue
- 24
- Pages
- 3406-3412
- ISSN
- 0264-410X (ISSN-L)
- OpenAlex
- W2050308265
- Cited by
- 346
- References
- 0
- FWCI
- 3.54
- Type
- journal article
- Language
- en
- Open access
- green
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