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Cited by 116Hepatitis B Virus StudiesHepatitis Viruses Studies and EpidemiologyTravel-related health issues

Immunogenicity of combined hepatitis A and B vaccine in elderly persons

Wolters, Bernd, Junge, Ulrich, Dziuba, Stefan, Roggendorf, Michael·2003·Vaccine
DOI 10.1016/s0264-410x(03)00399-2
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Abstract

More and more elderly people travel to areas where hepatitis A and B are endemic. Their immune system is less effective than in young persons. Therefore, it has to be insured that these travelers have protective immunity after vaccination. In a retrospective study we measured anti hepatitis virus (anti-HAV) and anti-HBs in elderly persons (N = 104, mean age 54 years) after combined hepatitis A/B vaccination under every-day conditions. After complete vaccination only 36 (34.6%) had antibodies against both viruses. Only 23 (29%) of 80 vaccinees older than 40 years were protected against hepatitis B and 52 (65%) against hepatitis A. The response to the vaccination decreased with increasing age. Vaccination against hepatitis B-but not against hepatitis A-was also influenced by the presence of chronic disease. After one booster 87% of the anti-HAV negative vaccinees developed protective anti-HAV antibodies. Anti-HBs can be expected in about 50% of the HBV negative vaccinees with every single booster. These results indicate that combined hepatitis A/B vaccination is not very effective in elderly persons. After complete vaccination their anti-HAV and anti-HBs antibodies have to be controlled to insure protection. In case of vaccination-failure boosters are very effective.

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Crossref · 10.1016/s0264-410x(03)00399-2

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33 of 33 references verified0 citation errors · 0 not checkable

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  • The immune system changes with age in nearly every aspect, generally leading to weaker pathogen immunity.

    “The immune system changes with age in nearly every aspect, generally resulting in a decline in pathogen immunity with increased age.”

    From SARS-CoV-2, COVID-19 and the aging immune system (2021) · cites this paper as [4]

  • Ageing is associated with high morbidity and mortality from various infections and with substantially lower vaccine efficacy.

    “ageing is associated with high morbidity and mortality rates for various infections and significant reductions in vaccine efficacy1-6”

    From SARS-CoV-2, COVID-19 and the aging immune system (2021) · cites this paper as [4]

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Authors
Wolters, B., Junge, U., Dziuba, S., & Roggendorf, M.
Affiliations
  • University of Duisburg-Essen (DE)
  • Klinikum Bielefeld (DE)
Corresponding author
Roggendorf, Michael
ORCID
Roggendorf, Michael
Venue
Vaccine
Publisher
Elsevier BV
Published
2003-09
Volume
21
Issue
25-26
Pages
3623-3628
ISSN
0264-410X (ISSN-L)
DOI
10.1016/s0264-410x(03)00399-2
OpenAlex
W1980161689
Cited by
116
References
38
Citations by year
2026: 2 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 10 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 3 · 2013: 5 · 2012: 10
FWCI
6.31
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Vaccine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
  • Health Sciences › Medicine › Hepatology › Hepatitis Viruses Studies and Epidemiology
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Travel-related health issues
Keywords
immunogenicity, older adults, anti-HAV antibodies, anti-HBs antibodies, vaccine response, booster vaccination, vaccine failure, chronic disease, travel vaccination, age-related immune decline
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Female, Health Status, Hepatitis B Surface Antigens, Humans, Immunization Schedule, Immunization, Secondary, Male, Middle Aged, Retrospective Studies, Hepatitis B Vaccines, Vaccines, Combined, Hepatitis A Vaccines, Hepatitis A Antibodies

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