The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Regression of experimental hamster cancer by beta carotene and algae extracts
Abstract
The effect of algae extract on tumor regression was studied. Phycotene (extract of Spirulina and Dunaliella algae) 250 micrograms in 0.1 ml MEM (minimum essential medium) was injected locally into DMBA (7, 12 dimethylbenz(a)anthracene)-induced squamous cell carcinomas of hamster buccal pouch in 20 animals. DMBA-induced carcinomas in 20 hamsters were injected locally with beta carotene 250 micrograms in 0.1 ml MEM; DMBA-induced carcinomas in 20 animals were injected locally with canthaxanthin, 250 micrograms in 0.1 ml MEM, and DMBA-induced carcinomas in 20 animals were injected locally with 13-cis-retinoic acid, 250 micrograms in 0.1 ml MEM. Twenty animals with DMBA-induced carcinomas were sham-injected controls using 0.1 ml MEM. The various agents were injected into the tumor bearing right buccal pouches twice-weekly for four weeks. Total tumor regression was found in 30% of phycotene animals, 20% of beta carotene animals and 15% of canthaxanthin animals after four weeks. Partial tumor regression was found in the remaining 70% of phycotene animals, 80% of beta carotene animals and 85% of canthaxanthin animals. None of the 13-cis-retinoic acid animals had total tumor regression, but 70% showed partial regression. No tumor regression was found in the DMBA control group and the sham-injected group.
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In the citing paper
“Total tumor regression was found in 30% and partial tumor regression was found in the remaining 70% of the animals after four weeks.”
From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [130]
In the citing paper
“The phycocyanin isolated from Arthrospira platensis showed anticancer activity against squamous cell carcinoma in hamsters [130].”
From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [130]
In the citing paper
“There was no evidence of toxicity in any of the animals receiving the algae extracts [130,131].”
From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [130]
Citations
Cites
Serum Beta-Carotene, Vitamins a and E, Selenium, and the Risk of Lung Cancer
Menkes, M., Comstock, G. W., Vuilleumier, J. P., Helsing, K. J., Rider, A. A., & Brookmeyer, R. (1986) · New England Journal of Medicine · doi:10.1056/nejm198611133152003 · Cited by 537
Chapter 15 Serial Cultivation of Normal Human Epidermal Keratinocytes
Rheinwald, J. G. (1980) · Methods in cell biology · doi:10.1016/s0091-679x(08)60769-4 · Cited by 266
Nitrous oxide analgesia: reversal by naloxone and development of tolerance.
Berkowitz, B. A., Finck, A. D., & Ngai, S. H. (1977) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)31080-3 · Cited by 196
Inhibition of experimental oral carcinogenesis by topical beta carotene
Suda, D., SCHWARTZ, J. L., & Shklar, G. (1986) · Carcinogenesis · doi:10.1093/carcin/7.5.711 · Cited by 186
Self-citationNitrous Oxide Effects on Cerebral Evoked Potential to Pain
Chapman, C. R., & Benedetti, C. (1979) · Anesthesiology · doi:10.1097/00000542-197908000-00009 · Cited by 124
Oral Mucosal Carcinogenesis in Hamsters: Inhibition by Vitamin E 2
Shklar, G. (1982) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/68.5.791 · Cited by 119
Self-citationSCHWARTZ, J. L., Suda, D., & Light, G. (1986) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(86)90451-1 · Cited by 102
Self-citationInhibition of hamster buccal pouch carcinogenesis by 13-cis-retinoic acid
Shklar, G., SCHWARTZ, J. L., Grau, D., Trickler, D. P., & Wallace, K. D. (1980) · Oral Surgery Oral Medicine Oral Pathology · doi:10.1016/0030-4220(80)90330-8 · Cited by 102
Self-citationRegression by Vitamin E of Experimental Oral Cancer
Shklar, G., SCHWARTZ, J. L., Trickler, D. P., & Niukian, K. (1987) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/78.5.987 · Cited by 67
Self-citationEffect of Nitrous Oxide Concentration on Event-related
Benedetti, C., Chapman, C. R., Colpitts, Y. H., & Chen, A. C. N. (1982) · Anesthesiology · doi:10.1097/00000542-198205000-00006 · Cited by 59
Research works printed but not linked: 4
- Shklar, 1982, Inhibition of oral mucosal carcinogenesis by vitamin E, J Natl Cancer Inst, 68, 791
- Odukoya, 1983, An epidermoid carcinoma cell line derived from hamster DMBA-induced buccal pouch tumors, J Natl Cancer Inst, 71, 1253
- Schwartz, 1986, Growth inhibition and destruction of oral cancer cells by extracts of spirulina, Am Acad Oral Pathol Abst, 40, 23
- Schwartz, 1987, Algae derived phycocyanin is both cytostatic and cytotoxic to oral squamous cell carcinoma (human or hamster), J Dent Res, 66, 160
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Items 101–109 of 109
Carotenoids in Cancer Chemoprevention and Therapeutic Interventions
Santamaria, L., & Bianchi-Santamaria, A. (1992) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.38.special_321
Labres, R. V. (2012) · Americanae (AECID Library)
EFECTO DE LA SPIRULINA MAXIMA CONTRA LA TERATOGENICIDAD Y GENOTOXICIDAD PRODUCIDAS POR HIDROXIUREA
Sanchez, J. V. (2012) · REMERI - Red Mexicana de Repositorios Institucionales
Significance of β-Carotene in Cancer
Basu, T. K., & Talmor, N. (1997) · Springer eBooks · doi:10.1007/978-4-431-67017-9_103
Spirulina: A Living Library of Anticancer Phytochemicals
Samson, A. O., Richard, O. O., & Yusuf, M. J. (2023) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815124699123010013
NUTRITIONAL AND THERAPEUTIC POTENTIAL OF SPIRULINA: MINI REVIEW
Kanwar, A., & Mathur, D. P. (2024) · doi:10.53555/eijbps.v10i1.53
Impact de la structure des aliments sur la biodisponibilité des micronutriments
Hiolle, M. (2019) · theses.fr (ABES) · doi:10.70675/fd44540czac6fz4725z8a8bz09af4feb0b3d
CAROTENOIDS PLUS VITAMIN A IN CANCER PREVENTION, ADJUVANT THERAPY, AND MASTALGIA TREATMENT
Santamaria, L., & Bianchi-Santamaria, A. (2005) · Elsevier eBooks · doi:10.1533/9781845698256.3.151
Metadata
- Authors
- Schwartz, J., & Shklar, G.
- Affiliations
- Harvard University (US)
- Corresponding author
- Shklar, Gerald
- ORCID
- Schwartz, Joel
- Venue
- Journal of Oral and Maxillofacial Surgery
- Publisher
- Elsevier BV
- Published
- 1987-06
- Volume
- 45
- Issue
- 6
- Pages
- 510-515
- ISSN
- 0278-2391 (ISSN-L)
- OpenAlex
- W2012180377
- Cited by
- 109
- References
- 13
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 2 · 2019: 6 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 7 · 2014: 2 · 2013: 5 · 2012: 4
- FWCI
- 13.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Oral and Maxillofacial Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- tumor regression, beta-carotene, algae extract, Spirulina, Dunaliella, canthaxanthin, isotretinoin, buccal pouch, hamster, oral cancer, chemoprevention
- MeSH terms
- Cyanobacteria, Chlorophyta, Animals, Carcinoma, Squamous Cell, Carotenoids, Cricetinae, Male, Mesocricetus, Mouth Mucosa, Mouth Neoplasms, Neoplasms, Multiple Primary, Plant Extracts, Remission Induction, Tretinoin, Vitamin E, Isotretinoin, Canthaxanthin
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