Cited by 109Seaweed-derived Bioactive CompoundsCancer and biochemical researchMedicinal Plant Research

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Regression of experimental hamster cancer by beta carotene and algae extracts

Schwartz, Joel, Shklar, Gerald·1987·Journal of Oral and Maxillofacial Surgery

Open this paper in CoChat — free account

Abstract

The effect of algae extract on tumor regression was studied. Phycotene (extract of Spirulina and Dunaliella algae) 250 micrograms in 0.1 ml MEM (minimum essential medium) was injected locally into DMBA (7, 12 dimethylbenz(a)anthracene)-induced squamous cell carcinomas of hamster buccal pouch in 20 animals. DMBA-induced carcinomas in 20 hamsters were injected locally with beta carotene 250 micrograms in 0.1 ml MEM; DMBA-induced carcinomas in 20 animals were injected locally with canthaxanthin, 250 micrograms in 0.1 ml MEM, and DMBA-induced carcinomas in 20 animals were injected locally with 13-cis-retinoic acid, 250 micrograms in 0.1 ml MEM. Twenty animals with DMBA-induced carcinomas were sham-injected controls using 0.1 ml MEM. The various agents were injected into the tumor bearing right buccal pouches twice-weekly for four weeks. Total tumor regression was found in 30% of phycotene animals, 20% of beta carotene animals and 15% of canthaxanthin animals after four weeks. Partial tumor regression was found in the remaining 70% of phycotene animals, 80% of beta carotene animals and 85% of canthaxanthin animals. None of the 13-cis-retinoic acid animals had total tumor regression, but 70% showed partial regression. No tumor regression was found in the DMBA control group and the sham-injected group.

Integrity signals

Registry

Crossref · 10.1016/s0278-2391(87)80011-3

Cites

13 of 13 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Serum Beta-Carotene, Vitamins a and E, Selenium, and the Risk of Lung Cancer
Menkes, M., Comstock, G. W., Vuilleumier, J. P., Helsing, K. J., Rider, A. A., & Brookmeyer, R. (1986) · New England Journal of Medicine · doi:10.1056/nejm198611133152003 · Cited by 537
Chapter 15 Serial Cultivation of Normal Human Epidermal Keratinocytes
Rheinwald, J. G. (1980) · Methods in cell biology · doi:10.1016/s0091-679x(08)60769-4 · Cited by 266
Nitrous oxide analgesia: reversal by naloxone and development of tolerance.
Berkowitz, B. A., Finck, A. D., & Ngai, S. H. (1977) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)31080-3 · Cited by 196
Inhibition of experimental oral carcinogenesis by topical beta carotene
Suda, D., SCHWARTZ, J. L., & Shklar, G. (1986) · Carcinogenesis · doi:10.1093/carcin/7.5.711 · Cited by 186
Self-citation
Nitrous Oxide Effects on Cerebral Evoked Potential to Pain
Chapman, C. R., & Benedetti, C. (1979) · Anesthesiology · doi:10.1097/00000542-197908000-00009 · Cited by 124
Oral Mucosal Carcinogenesis in Hamsters: Inhibition by Vitamin E 2
Shklar, G. (1982) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/68.5.791 · Cited by 119
Self-citation
Beta carotene is associated with the regression of hamster buccal pouch carcinoma and the induction of tumor necrosis factor in macrophages
SCHWARTZ, J. L., Suda, D., & Light, G. (1986) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(86)90451-1 · Cited by 102
Self-citation
Inhibition of hamster buccal pouch carcinogenesis by 13-cis-retinoic acid
Shklar, G., SCHWARTZ, J. L., Grau, D., Trickler, D. P., & Wallace, K. D. (1980) · Oral Surgery Oral Medicine Oral Pathology · doi:10.1016/0030-4220(80)90330-8 · Cited by 102
Self-citation
Regression by Vitamin E of Experimental Oral Cancer
Shklar, G., SCHWARTZ, J. L., Trickler, D. P., & Niukian, K. (1987) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/78.5.987 · Cited by 67
Self-citation
Effect of Nitrous Oxide Concentration on Event-related
Benedetti, C., Chapman, C. R., Colpitts, Y. H., & Chen, A. C. N. (1982) · Anesthesiology · doi:10.1097/00000542-198205000-00006 · Cited by 59

Show all 13 references

Research works printed but not linked: 4

Shklar, 1982, Inhibition of oral mucosal carcinogenesis by vitamin E, J Natl Cancer Inst, 68, 791
Odukoya, 1983, An epidermoid carcinoma cell line derived from hamster DMBA-induced buccal pouch tumors, J Natl Cancer Inst, 71, 1253
Schwartz, 1986, Growth inhibition and destruction of oral cancer cells by extracts of spirulina, Am Acad Oral Pathol Abst, 40, 23
Schwartz, 1987, Algae derived phycocyanin is both cytostatic and cytotoxic to oral squamous cell carcinoma (human or hamster), J Dent Res, 66, 160

Sorted by citations

Bioactive compounds from cyanobacteria and microalgae: an overview
Singh, S., Kate, B. N., & Banerjee, U. C. (2005) · Critical Reviews in Biotechnology · doi:10.1080/07388550500248498 · Cited by 619
Current knowledge on potential health benefits of Spirulina
Belay, A., Ota, Y., Miyakawa, K., & Shimamatsu, H. (1993) · Journal of Applied Phycology · doi:10.1007/bf00004024 · Cited by 465
Carotenoids and the Immune Response
Bendich, A. (1989) · Journal of Nutrition · doi:10.1093/jn/119.1.112 · Cited by 462
Microalgae as food and supplement
Kay, R. A., & Barton, L. L. (1991) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408399109527556 · Cited by 408
Antioxidant activity of the microalga Spirulina maxima
Miranda, M. S., Cintra, R. M. G. C., Barros, S. B. D. M., & Mancini-Filho, J. (1998) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x1998000800007 · Cited by 390
Spirulina in Clinical Practice: Evidence‐Based Human Applications
Karkos, P. D., Leong, S. C., Karkos, C. D., Sivaji, N., & Assimakopoulos, D. A. (2008) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/nen058 · Cited by 332
The potential application of Spirulina (Arthrospira) as a nutritional and therapeutic supplement in health management
Belay, A. (2002) · Medical Entomology and Zoology · Cited by 279
Spirulina (Arthrospira): Potential application as an animal feed supplement
Belay, A., Kato, T., & Ota, Y. (1996) · Journal of Applied Phycology · doi:10.1007/bf02178573 · Cited by 240
NUTRITIONAL AND TOXICOLOGICAL ASPECTS OF SPIRULINA (ARTHROSPIRA).
Gutiérrez-Salmeán, G., Castillo, L., & Chamorro, G. (2015) · PubMed · doi:10.3305/nh.2015.32.1.9001 · Cited by 224
Microalgae as second generation biofuel. A review
Singh, N., & Dhar, D. W. (2011) · Agronomy for Sustainable Development · doi:10.1007/s13593-011-0018-0 · Cited by 206
Review of Animal Models in Carotenoid Research
Lee, C. M., Boileau, A. C., Boileau, T. W.-M., Williams, A. W., Swanson, K. S., Heintz, K. A., & Erdman, J. W. (1999) · Journal of Nutrition · doi:10.1093/jn/129.12.2271 · Cited by 200
Effects of carotenoids in cellular and animal systems
Krinsky, N. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.1.238s · Cited by 197
Evaluation of chemoprevention of oral cancer with spirulina fusiformis
Mathew, B., Sankaranarayanan, R., Nair, P. P., Varghese, C., Somanathan, T., Amma, B. P., Amma, N. S., & Nair, M. K. (1995) · Nutrition and Cancer · doi:10.1080/01635589509514407 · Cited by 183
Supplementation of Spirulina platensis and Chlorella vulgaris Algae into Probiotic Fermented Milks
Beheshtipour, H., Mortazavian, A. M., Mohammadi, R., Sohrabvandi, S., & Khosravi‐Darani, K. (2013) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12004 · Cited by 178
Dietary Spirulina Platensis Enhances Humoral and Cell-Mediated Immune Functions in Chickens
Qureshi, M. A., Garlich, J. D., & Kidd, M. T. (1996) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923979609052748 · Cited by 172
Protective effect ofSpirulina against doxorubicin-induced cardiotoxicity
Khan, M., Shobha, J. C., Mohan, I. K., Naidu, M. U. R., Sundaram, C., Singh, S., Kuppusamy, P., & Kutala, V. K. (2005) · Phytotherapy Research · doi:10.1002/ptr.1783 · Cited by 159
Potential health benefits of spirulina microalgae*: A review of the existing literature
Capelli, B., & Cysewski, G. R. (2010) · Nutrafoods · doi:10.1007/bf03223332 · Cited by 147
Prevention of experimental oral cancer by extracts of Spirulina-Dunaliella algae
Schwartz, J., Shklar, G., Reid, S., & Trickier, D. (1988) · Nutrition and Cancer · doi:10.1080/01635588809513979 · Cited by 136
Self-citation
The beneficial effects of spirulina focusing on its immunomodulatory and antioxidant properties
Maddaly, R. (2010) · Nutrition and Dietary Supplements · doi:10.2147/nds.s9838 · Cited by 127
Tropical oils: Nutritional and scientific issues
Elson, C. E., & Alfin‐Slater, R. B. (1992) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408399209527562 · Cited by 123
‘Nutritional and healthical aspects of spirulina (Arthrospira) for poultry, animals and human.
Farag, M. R., Alagawany, M., Abd El-Hac, M. E., & Dhama, K. (2015) · International Journal of Pharmacology · doi:10.3923/ijp.2016.36.51 · Cited by 117
Tumor necrosis factor in experimental cancer regression with alphatocopherol, beta-carotene, canthaxanthin and algae extract
Shklar, G., & Schwartz, J. (1988) · European Journal of Cancer and Clinical Oncology · doi:10.1016/0277-5379(88)90192-7 · Cited by 117
Self-citation
Chemoprevention of rat liver toxicity and carcinogenesis by Spirulina
Ismail, M. F., Ali, D. A., Fernando, A., Abdraboh, M. E., Gaur, R. L., Ibrahim, W. M., Raj, M. H., & Ouhtit, A. (2009) · International Journal of Biological Sciences · doi:10.7150/ijbs.5.377 · Cited by 113
Microalgae for the prevention of cardiovascular disease and stroke
Raposo, M. F. D. J., & Morais, A. M. M. B. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.09.018 · Cited by 111
Bioactive Properties of Spirulina: A Review
Anvar, A. A., & Nowruzi, B. (2021) · Microbial Bioactives · doi:10.25163/microbbioacts.412117b0719110521 · Cited by 116
Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature
Gentscheva, G., Nikolova, K., Panayotova, V., Peycheva, K., Makedonski, L., Slavov, P., Radusheva, P., Petrova, P., & Yotkovska, I. (2023) · Life · doi:10.3390/life13030845 · Cited by 106
Pharmaceutical applications and consequent environmental impacts of Spirulina (Arthrospira): An overview
Shao, W., Ebaid, R., El-Sheekh, M. M., Abomohra, A., & Eladel, H. (2019) · Grasas y Aceites · doi:10.3989/gya.0690181 · Cited by 106
Bioavailability of a Natural Isomer Mixture as Compared with Synthetic all-trans-β-Carotene in Rats and Chicks
Ben‐Amotz, A., Mokady, S., Edelstein, S., & Avron, M. (1989) · Journal of Nutrition · doi:10.1093/jn/119.7.1013 · Cited by 106
Blue-Green Algae as an Immuno-Enhancer and Biomodulator
Jensen, G. S., Ginsberg, D. I., & Drapeau, C. (2001) · Cited by 104
Vitamin A and Lung Cancer
Willett, W. C. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1990.tb02936.x · Cited by 103
Spirulina (Arthrospira): An edible microorganism: A review
Sánchez, M. P. R., Bernal-Castillo, J., Rozo, C., & Rodríguez, I. (2003) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 93
Development of Experimental Oral Carcinogenesis and its Impact on Current Oral Cancer Resecuch
Mandel, I. D., & Shklar, G. (1999) · Journal of Dental Research · doi:10.1177/00220345990780120101 · Cited by 91
Self-citation
ENHANCEMENT OF CHICKEN MACROPHAGE PHAGOCYTIC FUNCTION AND NITRITE PRODUCTION BY DIETARY SPIRULINA PLATENSIS
Al-Batshan, H. A., Al-Mufarrej, S. I., Al-Homaidan, A. A., & Qureshi, M. A. (2001) · Immunopharmacology and Immunotoxicology · doi:10.1081/iph-100103866 · Cited by 88
Studies of immunomodulating actions of carotenoids. I. Effects ofβ‐carotene and astaxanthin on murine lymphocyte functions and cell surface marker expression inin vitroculture system
Jyonouchi, H., Hill, R. J., Tomita, Y., & Good, R. A. (1991) · Nutrition and Cancer · doi:10.1080/01635589109514148 · Cited by 84
Chemoprevention of oral carcinogenesis
Tanaka, T. (1995) · European Journal of Cancer Part B Oral Oncology · doi:10.1016/0964-1955(94)00026-z · Cited by 83
Food and drug industry applications of microalgae Spirulina platensis: A review
Maddiboyina, B., Vanamamalai, H. K., Roy, H., Ramaiah, Gandhi, S., Kavisri, M., & Moovendhan, M. (2023) · Journal of Basic Microbiology · doi:10.1002/jobm.202200704 · Cited by 80
Advances in delivery methods of Arthrospira platensis (spirulina) for enhanced therapeutic outcomes
ElFar, O. A., Billa, N., Lim, H. R., Chew, K. W., Cheah, W. Y., Munawaroh, H. S. H., Deepanraj, B., & Show, P. L. (2022) · Bioengineered · doi:10.1080/21655979.2022.2100863 · Cited by 87
Carotenoids as chemopreventive agents
Krinsky, N. I. (1989) · Preventive Medicine · doi:10.1016/0091-7435(89)90032-7 · Cited by 67
Antioxidant Vitamins and Their Functions in Immune Responses
Bendich, A. (1990) · Advances in experimental medicine and biology · doi:10.1007/978-1-4613-0553-8_4 · Cited by 66
Chemoprotective effect of Spirulina (Arthrospira) against cyclophosphamide-induced mutagenicity in mice
Chamorro, G., Garduño‐Siciliano, L., Barrón, B. L., Madrigal-Bujaidar, E., Cruz‐Vega, D. E., & Pagès, N. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.08.039 · Cited by 62
Sustainable production of energy from microalgae: Review of culturing systems, economics, and modelling
Zhou, X., Yuan, S., Chen, R., & Ochieng, R. M. (2015) · Journal of Renewable and Sustainable Energy · doi:10.1063/1.4906919 · Cited by 60
Nutritional and Pharmaceutical Properties of Microalgal Spirulina
Vo, T., Ngo, D., & Kim, S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800776-1.00019-4 · Cited by 67
Chemopreventive and antioxidant efficacy of (6)-paradol in 7, 12-dimethylbenz(a)anthracene induced hamster buccal pouch carcinogenesis
Kathiresan, S., Manoharan, S., Vijayaanand, M. A., & Govindasamy, S. (2010) · Pharmacological Reports · doi:10.1016/s1734-1140(10)70380-7 · Cited by 56
Microalgae in Medicine and Human Health
Borowitzka, M. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811405-6.00009-8 · Cited by 61
Oral cancer inhibition by micronutrients. The experimental basis for clinical trials
Shklar, G., & Schwartz, J. (1993) · European Journal of Cancer Part B Oral Oncology · doi:10.1016/0964-1955(93)90004-x · Cited by 53
Self-citation
Spirulina maxima pretreatment partially protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity
Chamorro, G., Pérez-Albiter, M., Serrano-García, N., Mares-Sámano, J. J., & Rojas, P. (2006) · Nutritional Neuroscience · doi:10.1080/10284150600929748 · Cited by 50
Acidic polysaccharides of Arthrospira (Spirulina) platensis induce the synthesis of TNF-α in RAW macrophages
Parages, M. L., Rico, R. M., Abdala-Díaz, R. T., Chabrillón, M., Sotiroudis, T. G., & Jiménez, C. (2012) · Journal of Applied Phycology · doi:10.1007/s10811-012-9814-4 · Cited by 49
Beta-Carotene Stimulates Human Leukocytes to Secrete a Novel Cytokine
Abril, E. R., Rybski, J. A., Scuderi, P., & WATSON, R. R. (1989) · Journal of Leukocyte Biology · doi:10.1002/jlb.45.3.255 · Cited by 49
C-Phycocyanin: An effective protective agent against thymic atrophy by tributyltin
Gupta, M., Dwivedi, U. N., & Khandelwal, S. (2011) · Toxicology Letters · doi:10.1016/j.toxlet.2011.03.029 · Cited by 44
Antioxidant properties of convective-air-dried Spirulina maxima : Evaluation of phycocyanin retention by a simple mathematical model of air-drying
Nakagawa, K., Ritcharoen, W., Sri-uam, P., Pavasant, P., & Adachi, S. (2016) · Food and Bioproducts Processing · doi:10.1016/j.fbp.2016.07.014 · Cited by 43
Spirulina platensis Extract Enhances Chicken Macrophage Functions After in vitro Exposure
Qureshi, M. A., Kidd, M. T., & Ali, R. A. (2008) · Journal of Nutritional Immunology · doi:10.1300/j053v03n04_04 · Cited by 39
Carotenoids in Medicine
Krinsky, N. I. (1989) · Springer eBooks · doi:10.1007/978-1-4613-0849-2_19 · Cited by 38
Effects of carotenoids on Aflatoxin B1‐induced mutagenesis inS. typhimuriumTA 100 and TA 98
He, Y., & Campbell, T. C. (1990) · Nutrition and Cancer · doi:10.1080/01635589009514066 · Cited by 37
Ameliorative Effects of Spirulina and Chamomile Aqueous Extract against Mice Bearing Ehrlich Solid Tumor Induced Apoptosis
El‐Atrsh, A., Tousson, E., Elnahas, E. E., Massoud, A. A., & Al-Zubaidi, M. (2019) · HAL · Cited by 34
Carotenoids and the Immune System
Bendich, A. (1989) · Springer eBooks · doi:10.1007/978-1-4613-0849-2_23 · Cited by 34
Carotenoids and Cancer: Basic Research Studies
Krinsky, N. I. (1994) · Elsevier eBooks · doi:10.1016/b978-0-08-057168-3.50014-x · Cited by 35
The Administration of Beta Carotene to Prevent and Regress Oral Carcinoma in the Hamster Cheek Pouch and the Associated Enhancement of the Immune Response
SCHWARTZ, J. L., Shklar, G., Flynn, E. A., & Trickler, D. P. (1990) · Advances in experimental medicine and biology · doi:10.1007/978-1-4613-0553-8_7 · Cited by 33
Self-citation
Spirulina platensisLacks Antitumor Effect against Solid Ehrlich Carcinoma in Female Mice
Barakat, W., Elshazly, S. M., & Mahmoud, A. A. A. (2015) · Advances in Pharmacological Sciences · doi:10.1155/2015/132873 · Cited by 32
Effects of Spirulina, a Blue-Green Alga, on Bone Metabolism in Ovariectomized Rats and Hindlimb-Unloaded Mice
Ishimi, Y., Sugiyama, F., Ezaki, J., Fujioka, M., & Jian, W. U. (2006) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.70.363 · Cited by 32
Long-term effect of Spirulina platensis extract on DMBA-induced hamster buccal pouch carcinogenesis (immunohistochemical study)
Grawish, M. E.-A., Zaher, A. R., Gaafar, A. I., & Nasif, W. A. (2009) · Medical Oncology · doi:10.1007/s12032-008-9164-x · Cited by 30
Chemoprevention targets for tobacco-related head and neck cancer: Past lessons and future directions
Sheth, S. H., Johnson, D. E., Kensler, T. W., & Bauman, J. E. (2015) · Oral Oncology · doi:10.1016/j.oraloncology.2015.02.101 · Cited by 29
Enhancement of immune activation activities of Spirulina maxima grown in deep-sea water
Choi, W., Kang, D., & Lee, H. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140612205 · Cited by 26
Bioactive Molecules of Spirulina: A Food Supplement
Mathur, M. (2019) · Reference series in phytochemistry · doi:10.1007/978-3-319-78030-6_97 · Cited by 26
Effects of carotenoid‐rich food extracts on the development of preneoplastic lesions in rat liver and on in vivo and in vitro antioxidant status
He, Y., Root, M. M., Parker, R. S., & Campbell, T. C. (1997) · Nutrition and Cancer · doi:10.1080/01635589709514532 · Cited by 26
Arthrospira Platensis – Potential in Dermatology and Beyond
Wollina, U., Voicu, C., Gianfaldoni, S., Lotti, T., França, K., & Tchernev, G. (2018) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2018.033 · Cited by 25
Efficacy of Spirulina platensis on immune functions in cancer mice with systemic candidiasis
Shokri, H., Khosravi, A., & Mahdi, T. (2014) · Cited by 24
Marine Bacterial Sources of Bioactive Compounds
Jaiganesh, R., & Kumar, N. S. S. (2012) · Advances in food and nutrition research · doi:10.1016/b978-0-12-416003-3.00025-1 · Cited by 23
The Hamster Cheek Pouch Model of Carcinogenesis and Chemoprevention
Gimenez-Conti, I. B., & Slaga, T. J. (1992) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-3468-6_9 · Cited by 24
Use of Spirulina Biomass
Vonshak, A. (1997) · CRC Press eBooks · doi:10.1201/9781482272970-19 · Cited by 21
Beta-carotene in vitro stimulates tumor necrosis factor alpha and interleukin 1 alpha secretion by human peripheral blood mononuclear cells
Abdel‐Fattah, G., Watzl, B., Huang, D. S., & WATSON, R. R. (1993) · Nutrition Research · doi:10.1016/s0271-5317(05)80589-5 · Cited by 21
Bioactive Molecules of Spirulina: A Food Supplement
Mathur, M. (2018) · Reference series in phytochemistry · doi:10.1007/978-3-319-54528-8_97-1 · Cited by 20
Retinoid and carotenoid angiogenesis: A possible explanation for enhanced oral carcinogenesis
SCHWARTZ, J. L., & Shklar, G. (1997) · Nutrition and Cancer · doi:10.1080/01635589709514524 · Cited by 19
Self-citation
Spirulina extract enriched for Braun‐type lipoprotein (Immulina®) for inhibition of 4T1 breast tumors' growth and metastasis
Kefayat, A., Ghahremani, F. H., Safavi, A., Hajiaghababa, A., & Moshtaghian, J. (2019) · Phytotherapy Research · doi:10.1002/ptr.6527 · Cited by 18
Antitumor effects of palm carotenes and tocotrienols in HRS/J hairless female mice
Tan, B. (1992) · Nutrition Research · doi:10.1016/s0271-5317(05)80461-0 · Cited by 18
A cyanobacteria extract and β‐carotene stimulate an antitumor host response against an oral cancer cell line
SCHWARTZ, J. L., & Shklar, G. (1989) · Phytotherapy Research · doi:10.1002/ptr.2650030605 · Cited by 17
Self-citation
Chemoprevention of upper aerodigestive tract cancers: A report of the third upper aerodigestive cancer task force workshop
Lippman, S. M., Lee, J. S., Lotan, R., & Hong, W. K. (1990) · Head & Neck · doi:10.1002/hed.2880120103 · Cited by 16
Synergistic Effects of Some Pairs of Antioxidants and Related Agents on Mouse Leukaemia L5 178Y Cell Growth In-vitro
Suzuki, T., Ezure, T., & Ishida, M. (1998) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1998.tb03330.x · Cited by 14
Chemoprevention of squamous cell carcinoma of the oral cavity
Brown, K. S., & Kane, M. A. (2006) · Otolaryngologic Clinics of North America · doi:10.1016/j.otc.2005.11.010 · Cited by 13
Free radicals as carcinogens and their quenchers as anticarcinogens
Santamaria, L., & Bianchi-Santamaria, A. (1991) · Medical Oncology and Tumor Pharmacotherapy · doi:10.1007/bf02987170 · Cited by 12
Chemoprevention of Penzo[a]pyrene-induced Carcinogen and Lipid Peroxidation in Mice by Lipophilic Algae Extracts (Phycotene)
Abdel-Baky, H. H., Gouda, E. M., ., A. N. E.-B., & El‐Baroty, G. S. (2002) · Journal of Medical Sciences(Faisalabad) · doi:10.3923/jms.2002.185.193 · Cited by 11
In vitro Antioxidant Activity of Marine Diatoms
Karthikeyan, P. (2013) · IOSR Journal of Environmental Science Toxicology and Food Technology · doi:10.9790/2402-0523237 · Cited by 11
In vivoandin vitroeffects of β‐carotene and algae extracts in murine tumor models
Combs, W., Sonis, S. T., Fitzgerald, J., Tracy, C., & Wilson, R. H. (1989) · Nutrition and Cancer · doi:10.1080/01635588909514038 · Cited by 9
Spirulina Unveiled: A Comprehensive Review on Biotechnological Innovations, Nutritional Proficiency, and Clinical Implications
Mittal, R. K., Krishna, G., Sharma, V., Purohit, P., & Mishra, R. (2024) · Current Pharmaceutical Biotechnology · doi:10.2174/0113892010304524240514023735 · Cited by 8
Efficacy of spirulina in management of oral submucous fibrosis − a systematic review
Kulkarni, R., Kalaskar, A. R., Kalaskar, R., & Gupta, N. (2022) · Journal of Oral Medicine and Oral Surgery · doi:10.1051/mbcb/2021052 · Cited by 8
Intérêt thérapeutique de la spiruline chez l’homme: revue général
Barry, M., Ouédraogo, M., Sourabie, S., & Guissou, I. (2015) · International Journal of Biological and Chemical Sciences · doi:10.4314/ijbcs.v8i6.33 · Cited by 8
Prevention of Oral Cancer
Malki, A. M., Raad, S. B., & Abu-El-Ruz, R. (2017) · Springer eBooks · doi:10.1007/978-3-319-48054-1_12 · Cited by 8
Spirulina: From Ancient Food to Innovative Super Nutrition of the Future and Its Market Scenario as a Source of Nutraceutical
Singh, S. K., Shukla, L., Yadav, N., Singh, P. K., Singh, S. M., Yadav, M. K., Kaushalendra, K., & Kumar, A. (2023) · Springer eBooks · doi:10.1007/978-981-99-0181-4_4 · Cited by 8
Antioxidative and Hepatoprotective Effects of Spirulina
Wu, L.-C., & Ho, J. A. (2007) · CRC Press eBooks · doi:10.1201/9781420052572.ch6 · Cited by 6
Evaluation of Different Biological Activities of Spirulina platensis Extracts
El-Din, S. M. M. (2019) · Egyptian Journal of Botany · doi:10.21608/ejbo.2019.11910.1306 · Cited by 4
Spirulina: An Emerging Treatment Modality for the Management of Oral Submucous Fibrosis
Desai, K. M., Hallikerimath, S. R., & Kale, A. D. (2017) · International Journal of Oral Care & Research · doi:10.5005/jp-journals-10051-0125 · Cited by 4
Overall Review on Therapeutic effects of Spirulina supplement
Shinde, S., Bhosale, M. S., Tambe, T., & Sonawane, P. (2022) · Research Journal of Science and Technology · doi:10.52711/2349-2988.2022.00019 · Cited by 4
Novel Development of Pasta Enriched with Spirulina platensis Microalgae: Biochemical and Histological Parameters
El-Sharnouby, G. A., Abughoush, M. H., & Choudhury, I. H. (2024) · Jordan Journal of Agricultural Sciences · doi:10.35516/jjas.v20i1.1142 · Cited by 7
Spirulina and Immunity
Keen, C. L., Belay, A., Gershwin, M. E., & Borchers, A. T. (2007) · CRC Press eBooks · doi:10.1201/9781420052572.ch8 · Cited by 3
DAFE'-E-SART'AN (ANTICANCER) ACTIVITY OF T'AH'LAB (SPIRULINA) - A REVIEW
Alam, M. A., Haider, N., Husain, S., Ahmad, S., & Alam, T. (2013) · Cited by 3
Effect of antibacterial properties of cyanobacterial Spirulina platensis
Xalxo, R. K., Sao, S., & Sahu, P. (2013) · Cited by 3
Spirulina and Immunity
Borchers, A. T., Belay, A., & Keen, C. L. (2007) · doi:10.1201/9781420052572-11 · Cited by 3
SPIRULINA – A WONDER NUTRACEUTICAL AGAINST CANCER: A REVIEW
Kaur, K., & Kaur, S. (2021) · PLANT ARCHIVES · doi:10.51470/plantarchives.2021.v21.no1.177 · Cited by 2
Spirulina Species
Smet, P. A. G. M. D. (1997) · Adverse effects of herbal drugs · doi:10.1007/978-3-642-60367-9_12 · Cited by 2
Spirulina Platensis: A Natural Product with many Biological Properties
Dixit, P., Ahmad, I., & Jafar, T. (2025) · doi:10.38124/ijisrt/25nov468 · Cited by 1
Environmental Chemicals
Schwartz, H. (1972) · Science News · doi:10.2307/3957443 · Cited by 1

Authors: Schwartz, J., & Shklar, G.
Affiliations: Harvard University (US)
Corresponding author: Shklar, Gerald
ORCID: Schwartz, Joel
Venue: Journal of Oral and Maxillofacial Surgery
Publisher: Elsevier BV
Published: 1987-06
Volume: 45
Issue: 6
Pages: 510-515
ISSN: 0278-2391 (ISSN-L)
DOI: 10.1016/s0278-2391(87)80011-3
OpenAlex: W2012180377
Cited by: 109
References: 13
Citations by year: 2025: 1 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 2 · 2019: 6 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 7 · 2014: 2 · 2013: 5 · 2012: 4
FWCI: 13.15
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Oral and Maxillofacial Surgery (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords: tumor regression, beta-carotene, algae extract, Spirulina, Dunaliella, canthaxanthin, isotretinoin, buccal pouch, hamster, oral cancer, chemoprevention
MeSH terms: Cyanobacteria, Chlorophyta, Animals, Carcinoma, Squamous Cell, Carotenoids, Cricetinae, Male, Mesocricetus, Mouth Mucosa, Mouth Neoplasms, Neoplasms, Multiple Primary, Plant Extracts, Remission Induction, Tretinoin, Vitamin E, Isotretinoin, Canthaxanthin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Regression of experimental hamster cancer by beta carotene and algae extracts

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks