Cited by 629Treatment of Major DepressionNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 198 of the 203 references it cites were found in a registry or an index.

Role of selective serotonin reuptake inhibitors in psychiatric disorders: a comprehensive review

Vaswani, Meera, Linda, Farzana Kadar, Ramesh, Subramanyam·2003·Progress in Neuro-Psychopharmacology and Biological Psychiatry

DOI 10.1016/s0278-5846(02)00338-x

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Abstract

The selective serotonin reuptake inhibitors (SSRIs) have emerged as a major therapeutic advance in psychopharmacology. As a result, the discovery of these agents marks a milestone in neuropsychopharmacology and rational drug design, and has launched a new era in psychotropic drug development. Prior to the SSRIs, all psychotropic medications were the result of chance observation. In an attempt to develop a SSRI, researchers discovered a number of nontricyclic agents with amine-uptake inhibitory properties, acting on both noradrenergic and serotonergic neurons with considerable differences in potency. A given drug may affect one or more sites over its clinically relevant dosing range and may produce multiple and different clinical effects. The enhanced safety profile includes a reduced likelihood of pharmacodynamically mediated adverse drug-drug interactions by avoiding affects on sites that are not essential to the intended outcome. SSRIs were developed for inhibition of the neuronal uptake pump for serotonin (5-HT), a property shared with the TCAs, but without affecting the other various neuroreceptors or fast sodium channels. The therapeutic mechanism of action of SSRIs involves alteration in the 5-HT system. The plethora of biological substrates, receptors and pathways for 5-HT are candidates to mediate not only the therapeutic actions of SSRIs, but also their side effects. A hypothesis to explain these immediate side effects is that 5-HT is increased at specific 5-HT receptor subtypes in discrete regions of the body where the relevant physiologic processes are regulated. Marked differences exist between the SSRIs with regard to effects on specific cytochrome P450 (CYP) enzymes, and thus the likelihood of clinically important pharmacokinetic drug-drug interactions. Although no clear relationship exists between the clinical efficacy, plasma concentration of SSRIs, nor any threshold that defines toxic concentrations, but therapeutic drug monitoring (TDM) may be useful in special populations, such as in elderly patients, poor metabolizers (PM) of sparteine (CYP2D6) or mephenytoin (CYP2C19), and patients with liver and kidney impairment. Several meta-analyses have reviewed the comparative efficacy of TCAs and SSRIs, and concluded that both TCAs and SSRIs have similar efficacy in the treatment of depression. SSRIs have demonstrated better efficacy and tolerability in the treatment of obsessive compulsive disorder (OCD). They have also been found to be effective in the treatment for social anxiety disorder both in reducing total levels of social anxiety and in improving overall clinical condition. The benefit of SSRIs in anorexia nervosa (AN) is apparently short-term unless medication is given in the context of nutritional or behavioral therapy. No single antidepressant can ever be recommended for every patient, but in a vast majority of patients, SSRIs should be considered as one of the first-line drugs in the treatment of depression.

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Selective serotonin reuptake inhibitors (SSRIs) versus other antidepressants for depression
Geddes, J. R., Freemantle, N., Mason, J. M., Eccles, M., & Boynton, J. R. (1999) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001851 · Cited by 109
Retracted
Lifetime and 12-Month Prevalence of DSM-III-R Psychiatric Disorders in the United States: Results From the National Comorbidity Survey
Kessler, R. C. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950010008002 · Cited by 12,370
Comprehensive Textbook of Psychiatry
Freedman, A. M., & Kaplan, H. I. (1967) · The American Journal of the Medical Sciences · doi:10.1097/00000441-196712000-00052 · Cited by 3,825
International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).
Hoyer, D., Clarke, D. E., Fozard, J. R., Hartig, P. R., Martin, G. R., Mylecharane, E. J., Saxena, P. R., & Humphrey, P. P. A. (1994) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06783-3 · Cited by 3,025
The serotonin syndrome
Sternbach, H. A. (1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.6.705 · Cited by 1,349
Selective serotonin reuptake inhibitors versus tricyclic antidepressants: a meta-analysis of efficacy and tolerability
Anderson, I. M. (2000) · Journal of Affective Disorders · doi:10.1016/s0165-0327(99)00092-0 · Cited by 940
Pharmacokinetics of selective serotonin reuptake inhibitors
Hiemke, C., & Härtter, S. (2000) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(99)00048-0 · Cited by 887
Inhibition and Induction of Cytochrome P450 and the Clinical Implications
Lin, J. H., & Lu, A. Y. H. (1998) · Clinical Pharmacokinetics · doi:10.2165/00003088-199835050-00003 · Cited by 827
Birth Outcomes in Pregnant Women Taking Fluoxetine
Chambers, C., Johnson, K. A., Dick, L. M., Felix, R. J., & Jones, K. L. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610033351402 · Cited by 735
Neurotransmitter Receptor and Transporter Binding Profile of Antidepressants and Their Metabolites
Owens, M. J., Morgan, W. N., Plott, S. J., & Nemeroff, C. B. (1997) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37161-7 · Cited by 676

Show all 203 references

Research works printed but not linked: 6

Bauman, 1995, The pharmacokinetics of citalopram, Rev. Contemp. Pharmacother., 6, 287
Geddes, 2000, SSRIs versus other antidepressants for depressive disorder, Cochrane Database Syst. Rev., 2
Mendels, 1995, Sertraline, vol. 2, 2073
Preskorn, 1991, Therapeutic drug monitoring for antidepressants: efficacy, safety and cost effectiveness, J. Clin. Psychiatry, 52, 23
Spigset, 1997, Non-linear fluvoxamine disposition and relation to some CYP activities, Eur. J. Clin. Pharmacol., 52, A172
van der Kolk, 1994, Fluoxetine in posttraumatic stress disorder, J. Clin. Psychiatry, 55, 517

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Zienowicz, M., Wisłowska, A., Lehner, M., Taracha, E., Skórzewska, A., Maciejak, P., & Płaźnik, A. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.10.009 · Cited by 44
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Williams, L. M., Carpenter, W. T., Carretta, C. M., Papanastasiou, E., & Vaidyanathan, U. (2023) · CNS Spectrums · doi:10.1017/s1092852923002420 · Cited by 49
Biosensors for psychiatric biomarkers in mental health monitoring
Wang, L., Hu, Y., Jiang, N., & Yetisen, A. K. (2024) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2024.116242 · Cited by 50
Differentially expressed genes related to major depressive disorder and antidepressant response: genome-wide gene expression analysis
Woo, H. I., Lim, S.-W., Myung, W., Kim, D. K., & Lee, S.-Y. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0123-0 · Cited by 42
Discovering the Potential Mechanisms of Medicinal Mushrooms Antidepressant Activity: A Review
Lazur, J., Hnatyk, K., Kała, K., Sułkowska‐Ziaja, K., & Muszyńska, B. (2023) · Antioxidants · doi:10.3390/antiox12030623 · Cited by 44
New insights into the neurobiological mechanisms of major depressive disorders
Fakhoury, M. (2015) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2015.01.005 · Cited by 45
Trypanosoma cruzi-induced depressive-like behavior is independent of meningoencephalitis but responsive to parasiticide and TNF-targeted therapeutic interventions
Vilar-Pereira, G., Silva, A. A., Pereira, I. R., da Silva, R. R., Moreira, O. C., de Almeida, L. R., de Souza, A. S., Rocha, M. S., & Lannes-Vieira, J. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.07.009 · Cited by 41
Identification of an allosteric modulator of the serotonin transporter with novel mechanism of action.
Kortagere, S., Fontana, A. C. K., Rose, D. R., & Mortensen, O. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.026 · Cited by 36
The promises and pitfalls of reboxetine.
Page, M. (2006) · CNS drug reviews · doi:10.1111/j.1527-3458.2003.tb00258.x · Cited by 38
Implication of 5-HT2 receptor subtypes in the mechanism of action of antidepressants in the four plates test
Dhonnchadha, B. �. N., Ripoll, N., Cl�net, F., Hascoët, M., & Bourin, M. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2044-y · Cited by 42
Tianeptine: An Antidepressant with Memory-Protective Properties
Zoladz, P. R., Park, C. R., Muñoz, C., Fleshner, M., & Diamond, D. M. (2008) · Current Neuropharmacology · doi:10.2174/157015908787386096 · Cited by 42
Serotonin transporter deficiency in rats contributes to impaired object memory
Olivier, J. D. A., Jans, L. A. W., Blokland, A., Broers, N. J., Homberg, J. R., Ellenbroek, B. A., & Cools, A. R. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00530.x · Cited by 45
Molecular fMRI of Serotonin Transport
Hai, A., Cai, L. X., Lee, T., Lelyveld, V. S., & Jasanoff, A. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.048 · Cited by 39
A PET study on regional coexpression of 5-HT1A receptors and 5-HTT in the human brain
Lundberg, J., Borg, J., Halldin, C., & Farde, L. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0928-3 · Cited by 40
Association between the serotonin transporter triallelic genotype and eating problems is moderated by the experience of childhood trauma in women
Stoltenberg, S. F., Anderson, C. M., Nag, P., & Anagnopoulos, C. (2012) · International Journal of Eating Disorders · doi:10.1002/eat.20976 · Cited by 41
Antidepressants, suicidality and rebound effect: evidence of similitude?
Teixeira, M. Z. (2009) · Homeopathy · doi:10.1016/j.homp.2009.02.004 · Cited by 39
Synergy effects of fluoxetine and variability in temperature lead to proportionally greater fitness costs in Daphnia: A multigenerational test
Barbosa, M., Inocentes, N., Soares, A. M. V. M., & Oliveira, M. (2017) · Aquatic Toxicology · doi:10.1016/j.aquatox.2017.10.017 · Cited by 43
The psychoactive drug Escitalopram affects swimming behaviour and increases boldness in zebrafish (Danio rerio)
Nielsen, S. V., Kellner, M., Henriksen, P., Olsén, H., Hansen, S. H., & Baatrup, E. (2018) · Ecotoxicology · doi:10.1007/s10646-018-1920-x · Cited by 38
Effects of selective serotonin reuptake inhibitors on three sex steroids in two versions of the aromatase enzyme inhibition assay and in the H295R cell assay
Jacobsen, N. W., Hansen, C. H., Nellemann, C., Styrishave, B., & Halling‐Sørensen, B. (2015) · Toxicology in Vitro · doi:10.1016/j.tiv.2015.07.005 · Cited by 38
Race Disparities in Psychiatric Rates in Emergency Departments.
Kunen, S., Niederhauser, R., Smith, P. O., Morris, J. A., & Marx, B. D. (2005) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.73.1.116 · Cited by 41
Hyponatremia associated with selective serotonin reuptake inhibitors, mirtazapine, and venlafaxine in Korean patients with major depressive disorder
Jung, Y.-E., Jun, T.-Y., Kim, K., & Bahk, W. M. (2011) · International Journal of Clinical Pharmacology and Therapeutics · doi:10.5414/cp201500 · Cited by 38
Serotonin regulates osteoblast proliferation and function in vitro
Dai, S., Yu, L. P., Shi, X., Wu, H., Shao, P. H., Yin, G., & Wei, Y. (2014) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20143565 · Cited by 37
The Serotonin 2C Receptor Antagonist SB 242084 Exhibits Abuse-Related Effects Typical of Stimulants in Squirrel Monkeys
Manvich, D. F., Kimmel, H. L., Cooper, D. A., & Howell, L. L. (2012) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.195156 · Cited by 37
A computational model of altered gait patterns in parkinson's disease patients negotiating narrow doorways
Muralidharan, V. (2014) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2013.00190 · Cited by 38
Different Views of Anxiety Disorders
Selek, S. (2011) · InTech eBooks · doi:10.5772/1022 · Cited by 39
Novel Vilazodone–Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation
Li, X., Wang, H., Xu, Y., Liu, W., Gong, Q., Wang, W., Qiu, X., Zhu, J., Mao, F., Zhang, H., et al. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00259 · Cited by 37
Glucocorticoid receptor deletion from the dorsal raphé nucleus of mice reduces dysphoria‐like behavior and impairs hypothalamic‐pituitary‐adrenocortical axis feedback inhibition
Vincent, M. Y., & Jacobson, L. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12538 · Cited by 37
Klotho Gene and Selective Serotonin Reuptake Inhibitors: Response to Treatment in Late-Life Major Depressive Disorder
Paroni, G., Seripa, D., Fontana, A., D’Onofrio, G., Gravina, C., Urbano, M., Addante, F., Lozupone, M., Copetti, M., Pilotto, A., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9711-y · Cited by 36
Design and Synthesis of Novel Tricyclic Benzoxazines as Potent 5-HT1A/B/D Receptor Antagonists Leading to the Discovery of 6-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}-4H-imidazo[5,1-c][1,4]benzoxazine-3-carboxamide (GSK588045)
Bromidge, S. M., Arban, R., Bertani, B., Bison, S., Borriello, M., Cavanni, P., Forno, G. D., Fabio, R. D., Donati, D., Fontana, S., et al. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm100482n · Cited by 36
The Cochrane Library and the treatment of childhood and adolescent anxiety disorders: an overview of reviews
Manassis, K., Russell, K. F., & Newton, A. S. (2010) · Evidence-Based Child Health A Cochrane Review Journal · doi:10.1002/ebch.508 · Cited by 36
Cardiovascular Health and Depression
Glassman, A. H., Shapiro, P. A., Ford, D. E., Culpepper, L., Finkel, M. S., Swenson, J. R., Bigger, J. T., Rollman, B. L., & Wise, T. N. (2003) · Journal of Psychiatric Practice · doi:10.1097/00131746-200311000-00004 · Cited by 35

Authors: Vaswani, M., Linda, F. K., & Ramesh, S.
Affiliations: All India Institute of Medical Sciences (IN)
Corresponding author: Vaswani, Meera
Venue: Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher: Elsevier BV
Published: 2003-02
Volume: 27
Issue: 1
Pages: 85-102
ISSN: 0278-5846 (ISSN-L)
DOI: 10.1016/s0278-5846(02)00338-x
OpenAlex: W1988612597
Cited by: 612
References: 203
Citations by year: 2026: 16 · 2025: 17 · 2024: 20 · 2023: 30 · 2022: 19 · 2021: 30 · 2020: 10 · 2019: 22 · 2018: 28 · 2017: 27 · 2016: 23 · 2015: 37 · 2014: 24 · 2013: 29 · 2012: 27
FWCI: 3.58
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: selective serotonin reuptake inhibitors, serotonin, serotonin receptors, antidepressant mechanism, adverse drug reactions, drug-drug interactions, cytochrome P450, therapeutic drug monitoring, tricyclic antidepressants, depression, obsessive-compulsive disorder, social anxiety disorder, anorexia nervosa, bulimia nervosa, eating disorders, sleep disorders
MeSH terms: Adolescent, Adult, Age Factors, Aged, Anxiety Disorders, Feeding and Eating Disorders, Child, Depressive Disorder, Female, Humans, Male, Middle Aged, Pregnancy, Pregnancy Complications, Substance Withdrawal Syndrome, Suicide, Attempted, Selective Serotonin Reuptake Inhibitors

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Role of selective serotonin reuptake inhibitors in psychiatric disorders: a comprehensive review

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