Differentially expressed genes related to major depressive disorder and antidepressant response: genome-wide gene expression analysis
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Treatment response to antidepressants is limited and varies among patients with major depressive disorder (MDD). To discover genes and mechanisms related to the pathophysiology of MDD and antidepressant treatment response, we performed gene expression analyses using peripheral blood specimens from 38 MDD patients and 14 healthy individuals at baseline and at 6 weeks after the initiation of either selective serotonin reuptake inhibitor (SSRI) or mirtazapine treatment. The results were compared with results from public microarray data. Seven differentially expressed genes (DEGs) between MDD patients and controls were identified in our study and in the public microarray data: CD58, CXCL8, EGF, TARP, TNFSF4, ZNF583, and ZNF587. CXCL8 was among the top 10 downregulated genes in both studies. Eight genes related to SSRI responsiveness, including BTNL8, showed alterations in gene expression in MDD. The expression of the FCRL6 gene differed between SSRI responders and nonresponders and changed after SSRI treatment compared to baseline. In evaluating the response to mirtazapine, 21 DEGs were identified when comparing MDD patients and controls and responders and nonresponders. These findings suggest that the pathophysiology of MDD and treatment response to antidepressants are associated with a number of processes, including DNA damage and apoptosis, that can be induced by immune activation and inflammation.
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The TNFSF4 gene has been observed to be downregulated in MDD patients in a genome-wide gene expression analysis.
“This TNF Superfamily Member 4 (TNFSF4) gene has been observed to be downregulated in MDD patients in a genome-wide gene expression analysis (Woo et al., 2018).”
From Epigenome-wide DNA methylation in unipolar depression: predictive biomarker of antidepressant treatment response? (2024) · cites this paper as Woo et al., 2018
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Schiele, M. A., Crespo Salvador, O., Lipovsek, J., Schwarte, K., Schlosser, P., Zwanzger, P., Arolt, V., Baune, B. T., Köttgen, A., & Domschke, K. (2024) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyae045 · Cited by 13 · see citing works
- Authors
- Woo, H. I., Lim, S.-W., Myung, W., Kim, D. K., & Lee, S.-Y.
- Affiliations
- Samsung Changwon Hospital (KR)
- Samsung Medical Center (KR)
- Seoul National University (KR)
- Corresponding author
- Kim, Doh Kwan
- Lee, Soo-Youn
- Venue
- Experimental & Molecular Medicine
- Published
- 2018-08
- Volume
- 50
- Issue
- 8
- Pages
- 1-11
- ISSN
- 1226-3613 (ISSN-L)
- 2092-6413
- PMC
- PMC6076250
- OpenAlex
- W2885056959
- Cited by
- 42
- References
- 87
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 8 · 2023: 7 · 2022: 6 · 2021: 5 · 2020: 7 · 2019: 6
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Experimental & Molecular Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Research Foundation
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- major depressive disorder, antidepressant response, treatment-resistant depression, differentially expressed genes, peripheral blood gene expression, selective serotonin reuptake inhibitors, mirtazapine, interleukin-8, CD58, immune activation, inflammation, DNA damage, apoptosis
- MeSH terms
- Mirtazapine, Aged, Antidepressive Agents, Depressive Disorder, Major, Major Depressive Disorder, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Genome, Human, Cluster Analysis, Case-Control Studies, Treatment Outcome, Selective Serotonin Reuptake Inhibitors, Gene Expression Profiling, Gene Regulatory Networks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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