123I ADAM SPECT imaging of serotonin transporter binding in patients with night eating syndrome: a preliminary report
Open accessAbstract
Night eating syndrome (NES) represents a delay in the circadian pattern of food intake, manifested by evening hyperphagia and/or nocturnal awakenings accompanied by ingestions of food. A neurobiological marker of NES has been implicated with the recently discovered therapeutic response to the selective serotonin reuptake inhibitor (SSRI) sertraline. This pilot SPECT (single photon emission computed tomography) study compared the serotonin transporter (SERT) uptake ratios of night eaters with those of healthy controls. Six night eaters underwent SPECT imaging using the radiopharmaceutical (123)I-ADAM. Uptake, compared with that of the cerebellum, was obtained for the midbrain, basal ganglia, and temporal lobes; uptake ratios in night eaters were compared with those of six healthy controls. Night eaters had significantly greater SERT uptake ratios in the midbrain than healthy controls. These findings, in conjunction with the therapeutic response of NES to sertraline, indicate that the serotonin system is involved in the pathophysiology of NES.
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Such interventions suggest possible relationships with 5-HT transporter changes, supported by SPECT studies.
“Such interventions suggest possible relationships with 5-HT transporter changes, supported by SPECT studies (Lundgren et al., 2008).”
From Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges (2009) · cites this paper as Lundgren et al., 2008
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- Authors
- Lundgren, J. D., Newberg, A. B., Allison, K. C., Wintering, N. A., Ploessl, K., & Stunkard, A. J.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Stunkard, Albert J.
- Venue
- Psychiatry Research Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 162
- Issue
- 3
- Pages
- 214-220
- ISSN
- 0925-4927 (ISSN-L)
- PMC
- PMC2441922
- OpenAlex
- W1973102090
- Cited by
- 55
- References
- 34
- Citations by year
- 2025: 2 · 2024: 2 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 1 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 5 · 2012: 4
- FWCI
- 7.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK056735)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- night eating syndrome, serotonin transporter, SPECT imaging, sertraline, selective serotonin reuptake inhibitors, serotonergic system, midbrain, basal ganglia, temporal lobe, neuroimaging biomarkers
- MeSH terms
- Adult, Basal Ganglia, Binding Sites, Brain, Cerebellum, Cinanserin, Circadian Rhythm, Female, Humans, Iodides, Iodine Radioisotopes, Male, Mesencephalon, Protein Binding, Surveys and Questionnaires, Temporal Lobe, Thyroid Gland, Tomography, Emission-Computed, Single-Photon, Diagnostic and Statistical Manual of Mental Disorders, Serotonin Plasma Membrane Transport Proteins, Bulimia Nervosa
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